(Q34150587)

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Akt pathway is hypoactivated by synergistic actions of diabetes mellitus and hypercholesterolemia resulting in advanced coronary artery disease

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scholarly article

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Europe PubMed Central

PubMed publication ID

31 July 2017

Akt pathway is hypoactivated by synergistic actions of diabetes mellitus and hypercholesterolemia resulting in advanced coronary artery disease (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

hypercholesterolemia

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coronary artery disease

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based on heuristic

inferred from title

Morris J. Birnbaum

object named as

Morris J Birnbaum

10

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author name string

Damir Hamamdzic

1

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Robert S Fenning

2

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Europe PubMed Central

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31 July 2017

Dhavalkumar Patel

3

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Emile R Mohler

4

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Ksenia A Orlova

5

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Alexander C Wright

6

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Raul Llano

7

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Martin G Keane

8

1 reference

Europe PubMed Central

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31 July 2017

Richard P Shannon

9

1 reference

Europe PubMed Central

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31 July 2017

Robert L Wilensky

11

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31 July 2017

publication date

2 July 2010

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Europe PubMed Central

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31 July 2017

American Journal of Physiology Heart and Circulatory Physiology

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Europe PubMed Central

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31 July 2017

299

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

H699-706

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Ox-LDL modifies the behaviour of bone marrow stem cells and impairs their endothelial differentiation via inhibition of Akt phosphorylation

1 reference

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5 July 2018

Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis.

1 reference

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5 July 2018

Prevention of vasa vasorum neovascularization attenuates early neointima formation in experimental hypercholesterolemia

1 reference

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5 July 2018

Valproate attenuates accelerated atherosclerosis in hyperglycemic apoE-deficient mice: evidence in support of a role for endoplasmic reticulum stress and glycogen synthase kinase-3 in lesion development and hepatic steatosis

1 reference

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5 July 2018

PI3K/Akt: getting it right matters

1 reference

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5 July 2018

Maintenance of constitutive IkappaB kinase activity by glycogen synthase kinase-3alpha/beta in pancreatic cancer

1 reference

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5 July 2018

Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development

1 reference

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5 July 2018

Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages

1 reference

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The regulation of cell motility and chemotaxis by phospholipid signaling

1 reference

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5 July 2018

Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

Protein kinase B: signalling roles and therapeutic targeting

1 reference

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5 July 2018

The molecular basis of vulnerable plaque: potential therapeutic role for immunomodulation

1 reference

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5 July 2018

Molecular mechanisms of plaque instability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

AKT/PKB signaling: navigating downstream

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

Mechanisms for oxidative stress in diabetic cardiovascular disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

The immune response in atherosclerosis: a double-edged sword

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

Akt: versatile mediator of cell survival and beyond

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

Glycogen synthase kinase 3beta functions to specify gene-specific, NF-kappaB-dependent transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

Nuclear factor kappaB signaling in atherogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

Vascular endothelial growth factor transcriptional activation is mediated by hypoxia-inducible factor 1alpha, HDM2, and p70S6K1 in response to phosphatidylinositol 3-kinase/AKT signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

trans-3,4,5'-Trihydroxystibene inhibits hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in human ovarian cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

Oxidized LDL inhibits vascular endothelial growth factor-induced endothelial cell migration by an inhibitory effect on the Akt/endothelial nitric oxide synthase pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells

1 reference

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5 July 2018

Cellular survival: a play in three Akts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

Induction of NF-kappaB by the Akt/PKB kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

Atherosclerosis — An Inflammatory Disease

1 reference

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5 July 2018

Induction of macrophage VEGF in response to oxidized LDL and VEGF accumulation in human atherosclerotic lesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

Enhanced coronary vasa vasorum neovascularization in experimental hypercholesterolemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

Membrane translocation and activation of the Akt kinase in growth factor-stimulated hematopoietic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

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Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

Angiogenesis in human coronary atherosclerotic plaques

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

5 July 2018

Hypothesis: vasa vasorum and neovascularization of human coronary arteries. A possible role in the pathophysiology of atherosclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944488

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Basic fibroblast growth factor enhances the coupling of intimal hyperplasia and proliferation of vasa vasorum in injured rat arteries

1 reference

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5 July 2018

Morphologic findings of coronary atherosclerotic plaques in diabetics: a postmortem study

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00071.2010

21 January 2018

Chronic estradiol administration in vivo promotes the proinflammatory response of macrophages to TLR4 activation: involvement of the phosphatidylinositol 3-kinase pathway.

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00071.2010

21 January 2018

Diabetes-induced accelerated atherosclerosis in swine

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00071.2010

21 January 2018

Increased spatial vasa vasorum density in the proximal LAD in hypercholesterolemia--implications for vulnerable plaque-development.

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00071.2010

21 January 2018

Vascular neointimal formation and signaling pathway activation in response to stent injury in insulin-resistant and diabetic animals

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00071.2010

21 January 2018

Oxidized low density lipoprotein impairs endothelial progenitor cells by regulation of endothelial nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00071.2010

21 January 2018

Site-specific atherogenic gene expression correlates with subsequent variable lesion development in coronary and peripheral vasculature

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00071.2010

21 January 2018

Plaque Neovascularization Is Increased in Ruptured Atherosclerotic Lesions of Human Aorta

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00071.2010

21 January 2018

Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice.

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00071.2010

21 January 2018

Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element

1 reference

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28 October 2018

Arterial neovascularization and inflammation in vulnerable patients: early and late signs of symptomatic atherosclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20601459

12 December 2020

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Correlation of vasa vasorum neovascularization and plaque progression in aortas of apolipoprotein E(-/-)/low-density lipoprotein(-/-) double knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20601459

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidized phospholipids stimulate angiogenesis via autocrine mechanisms, implicating a novel role for lipid oxidation in the evolution of atherosclerotic lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/20601459

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated nuclear factor-kappaB is present in the coronary vasculature in experimental hypercholesterolemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/20601459

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coronary composition and macrophage infiltration in atherectomy specimens from patients with diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20601459

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1152/AJPHEART.00071.2010

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

ResearchGate publication ID

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