(Q37310202)

19 August 2017

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title

PI3K/Akt: getting it right matters (English)

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19 August 2017

T F Franke

1

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PubMed ID

18955974

19 August 2017

language of work or name

English

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publication date

1 October 2008

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19 August 2017

16

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based on heuristic

inferred from page(s)

published in

Oncogene

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19 August 2017

27

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19 August 2017

6473-6488

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19 August 2017

50

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https://scigraph.springernature.com/pub.10.1038/onc.2008.313

19 August 2017

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cites work

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Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

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A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis

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The akt kinase: molecular determinants of oncogenicity

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Neurodevelopment, neuroplasticity, and new genes for schizophrenia

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Phosphorylation of HDM2 by Akt.

31 March 2020

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PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

31 March 2020

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The PIK3CA gene is mutated with high frequency in human breast cancers.

31 March 2020

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Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B.

31 March 2020

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PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

31 March 2020

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Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1.

31 March 2020

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Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival

31 March 2020

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Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

31 March 2020

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The Akt-GSK-3 signaling cascade in the actions of dopamine

31 March 2020

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An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior

31 March 2020

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Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade

31 March 2020

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A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

31 March 2020

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The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway

31 March 2020

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Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles.

31 March 2020

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The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes

31 March 2020

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Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

31 March 2020

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AKT1(E17K) in human solid tumours

31 March 2020

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PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival

31 March 2020

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Ten years of protein kinase B signalling: a hard Akt to follow

31 March 2020

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PKB binding proteins. Getting in on the Akt.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.313

PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.313

A new mutational AKTivation in the PI3K pathway

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.313

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.313

Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.313

Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.313

Mutation of the PIK3CA gene in ovarian and breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Regulation of cell death protease caspase-9 by phosphorylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Phosphatidylinositol 3,4,5-trisphosphate is formed from phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Role of Akt and c-Jun N-terminal kinase 2 in apoptosis induced by interleukin-4 deprivation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Molecular genetic advances in tuberous sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Ca(2+)/calmodulin directly interacts with the pleckstrin homology domain of AKT1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Cell biology: metabolism meets death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Regulation of the Akt kinase by interacting proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Regulation of neuronal survival by the serine-threonine protein kinase Akt

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

IRS-1: auditing the effectiveness of mTOR inhibitors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Role for Akt3/protein kinase Bgamma in attainment of normal brain size

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt2 Negatively Regulates Assembly of the POSH-MLK-JNK Signaling Complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt-interacting proteins: attractive opposites. focus on "Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways".

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Intracellular signaling by Akt: bound to be specific

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

31 March 2020

A Bad kinase makes good

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

PI3K/Akt and apoptosis: size matters

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Apoptosis meets signal transduction: elimination of a BAD influence

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

A family with severe insulin resistance and diabetes due to a mutation in AKT2.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Patterns of somatic mutation in human cancer genomes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Defining the role of mTOR in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

RalGDS couples growth factor signaling to Akt activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Restraining PI3K: mTOR signalling goes back to the membrane.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Beta-synuclein regulates Akt activity in neuronal cells. A possible mechanism for neuroprotection in Parkinson's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Signalling through Class I PI3Ks in mammalian cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

A role for protein kinase Bbeta/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Characterization of PDK2 activity against protein kinase B gamma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Inhibition of 5-HT1A receptor-dependent cell survival by cAMP/protein kinase A: role of protein phosphatase 2A and Bax.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

PKB/Akt interacts with inosine-5' monophosphate dehydrogenase through its pleckstrin homology domain.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Role for the adaptor protein Grb10 in the activation of Akt

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Inositol 1,3,4,5-tetrakisphosphate negatively regulates phosphatidylinositol-3,4,5- trisphosphate signaling in neutrophils

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Molecular cloning of a second form of rac protein kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

JNK-interacting protein 1 promotes Akt1 activation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt1 regulates a JNK scaffold during excitotoxic apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Molecular cloning of rat RAC protein kinase alpha and beta and their association with protein kinase C zeta

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Pten regulates neuronal arborization and social interaction in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt protein kinase inhibits Rac1-GTP binding through phosphorylation at serine 71 of Rac1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

A role for the PI-3 kinase signaling pathway in fear conditioning and synaptic plasticity in the amygdala

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Identification of CISK, a new member of the SGK kinase family that promotes IL-3-dependent survival

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Protein kinase Cepsilon activates protein kinase B/Akt via DNA-PK to protect against tumor necrosis factor-alpha-induced cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Regulation of the Pro-apoptotic scaffolding protein POSH by Akt.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Estrogen Inhibits Paclitaxel-Induced Apoptosis via the Phosphorylation of Apoptosis Signal-Regulating Kinase 1 in Human Ovarian Cancer Cell Lines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

PTEN: its deregulation and tumorigenesis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

mTOR, translation initiation and cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

AKT/PKB signaling: navigating downstream

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Proto-oncogene TCL1: more than just a coactivator for Akt

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt phosphorylation and neuronal survival after traumatic brain injury in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt enhances Mdm2-mediated ubiquitination and degradation of p53.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Insulin-like growth factor-I inhibits the stress-activated protein kinase/c-Jun N-terminal kinase.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Induction of ovarian cancer by defined multiple genetic changes in a mouse model system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Homeostatic control of lymphocyte survival: potential origins and implications

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Multiplicity of mechanisms of serotonin receptor signal transduction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Stress and mTORture signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt activity in Alzheimer's disease and other neurodegenerative disorders

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt/GSK3beta serine/threonine kinases: evidence for a signalling pathway mediated by familial Alzheimer's disease mutations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt1/PKBalpha protects PC12 cells against the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium and reduces the levels of oxygen-free radicals

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Tenets of PTEN tumor suppression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

High frequency of mutations of the PIK3CA gene in human cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

PKB/AKT: functional insights from genetic models

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Ras, PI(3)K and mTOR signalling controls tumour cell growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

The conserved phosphoinositide 3-kinase pathway determines heart size in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt/protein kinase B promotes organ growth in transgenic mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

The consensus coding sequences of human breast and colorectal cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Regulation of PTEN transcription by p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Genetic analysis of protein kinase B (AKT) in Drosophila

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Selective interaction between leptin and insulin signaling pathways in a hepatic cell line

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Cellular signaling: pivoting around PDK-1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Protein kinase B beta/Akt2 plays a specific role in muscle differentiation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Autism and tuberous sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Novel PtdIns(3)P-binding protein Etf1 functions as an effector of the Vps34 PtdIns 3-kinase in autophagy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

ArgBP2gamma interacts with Akt and p21-activated kinase-1 and promotes cell survival

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Ras GTPase-activating protein binds to Akt and is required for its activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Isoform-specific regulation of adipocyte differentiation by Akt/protein kinase Bα

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt regulates cell survival and apoptosis at a postmitochondrial level

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

Akt is essential for insulin modulation of amphetamine-induced human dopamine transporter cell-surface redistribution

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.313

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/ONC.2008.313

1 reference

19 August 2017

1 reference

PubMed ID

18955974