(Q30157958)

8 June 2017

Regulation of the Pro-apoptotic scaffolding protein POSH by Akt. (English)

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8 June 2017

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Traci R Lyons

1

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8 June 2017

Jackie Thorburn

2

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8 June 2017

Philip W Ryan

3

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8 June 2017

Andrew Thorburn

4

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8 June 2017

Steven M Anderson

5

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8 June 2017

C Kenneth Kassenbrock

6

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8 June 2017

language of work or name

English

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publication date

29 May 2007

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Journal of Biological Chemistry

8 June 2017

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8 June 2017

282

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8 June 2017

30

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8 June 2017

21987-21997

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A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways

8 June 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

Direct interaction of the molecular scaffolds POSH and JIP is required for apoptotic activation of JNKs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

Knock-down of POSH expression is neuroprotective through down-regulating activation of the MLK3-MKK4-JNK pathway following cerebral ischaemia in the rat hippocampal CA1 subfield

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

Novel function of POSH, a JNK scaffold, as an E3 ubiquitin ligase for the Hrs stability on early endosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

Regulation of apoptotic c-Jun N-terminal kinase signaling by a stabilization-based feed-forward loop.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

Siah1 interacts with the scaffold protein POSH to promote JNK activation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

The neuroprotection of insulin on ischemic brain injury in rat hippocampus through negative regulation of JNK signaling pathway by PI3K/Akt activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

Akt1 regulates a JNK scaffold during excitotoxic apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M704321200

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

Direct control of the Forkhead transcription factor AFX by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

Akt2 Negatively Regulates Assembly of the POSH-MLK-JNK Signaling Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

A mammalian expression system for rapid production and purification of active MAP kinase phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

Activation of the apoptotic JNK pathway through the Rac1-binding scaffold protein POSH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

Akt protein kinase inhibits Rac1-GTP binding through phosphorylation at serine 71 of Rac1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

JNK-interacting protein 1 promotes Akt1 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704321200

21 January 2018

Identifiers

DOI

10.1074/JBC.M704321200

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8 June 2017

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