(Q34150973)

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Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late-stage central nervous system african trypanosomiasis

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scholarly article

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Europe PubMed Central

31 July 2017

Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late-stage central nervous system african trypanosomiasis (English)

1 reference

Europe PubMed Central

31 July 2017

trypanosomiasis

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African trypanosomiasis

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1 reference

based on heuristic

inferred from title

14

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31 July 2017

6

object named as

Reto Brun

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Europe PubMed Central

31 July 2017

author name string

Bakela Nare

1

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Europe PubMed Central

31 July 2017

Stephen Wring

2

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Europe PubMed Central

31 July 2017

Cyrus Bacchi

3

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Europe PubMed Central

31 July 2017

Beth Beaudet

4

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Europe PubMed Central

31 July 2017

Tana Bowling

5

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Europe PubMed Central

31 July 2017

Daitao Chen

7

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Europe PubMed Central

31 July 2017

Charles Ding

8

1 reference

Europe PubMed Central

31 July 2017

Yvonne Freund

9

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Europe PubMed Central

31 July 2017

Eric Gaukel

10

1 reference

Europe PubMed Central

31 July 2017

Ali Hussain

11

1 reference

Europe PubMed Central

31 July 2017

Kurt Jarnagin

12

1 reference

Europe PubMed Central

31 July 2017

Matthew Jenks

13

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31 July 2017

Luke Mercer

15

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Europe PubMed Central

31 July 2017

Elena Mejia

16

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Europe PubMed Central

31 July 2017

Andy Noe

17

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Europe PubMed Central

31 July 2017

Matt Orr

18

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Europe PubMed Central

31 July 2017

Robin Parham

19

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Europe PubMed Central

31 July 2017

Jacob Plattner

20

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Europe PubMed Central

31 July 2017

Ryan Randolph

21

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Europe PubMed Central

31 July 2017

Donna Rattendi

22

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Europe PubMed Central

31 July 2017

Cindy Rewerts

23

1 reference

Europe PubMed Central

31 July 2017

Jessica Sligar

24

1 reference

Europe PubMed Central

31 July 2017

Nigel Yarlett

25

1 reference

Europe PubMed Central

31 July 2017

Robert Don

26

1 reference

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31 July 2017

Robert Jacobs

27

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31 July 2017

language of work or name

0 references

publication date

26 July 2010

1 reference

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31 July 2017

Antimicrobial Agents and Chemotherapy

1 reference

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31 July 2017

54

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31 July 2017

10

1 reference

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31 July 2017

4379-4388

1 reference

Europe PubMed Central

31 July 2017

Biopharmaceutics classification system: validation and learnings of an in vitro permeability assay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

The continuing problem of human African trypanosomiasis (sleeping sickness).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

Eliminating human African trypanosomiasis: where do we stand and what comes next?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

Recent progress on the topical therapy of onychomycosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

Semimechanistic pharmacokinetic/pharmacodynamic model for assessment of activity of antibacterial agents from time-kill curve experiments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

Improving the in vitro prediction of in vivo central nervous system penetration: integrating permeability, P-glycoprotein efflux, and free fractions in blood and brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

In vitro absorption and secretory quotients: practical criteria derived from a study of 331 compounds to assess for the impact of P-glycoprotein-mediated efflux on drug candidates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

Antigenic variation in African trypanosomes: monitoring progress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

Human African trypanosomiasis of the CNS: current issues and challenges

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

Issues in pharmacokinetics and pharmacodynamics of anti-infective agents: kill curves versus MIC

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

Antitrypanosomal activities of proteasome inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

The phenomenon of treatment failures in Human African Trypanosomiasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

Rational use of in vitro P-glycoprotein assays in drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

Pharmacokinetic investigations in patients from northern Angola refractory to melarsoprol treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

Pharmacological approaches to antitrypanosomal chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

In vitro and in vivo activities of trybizine hydrochloride against various pathogenic trypanosome species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

The Alamar Blue assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

In vivo trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

Combination chemotherapy of drug-resistant Trypanosoma brucei rhodesiense infections in mice using DL-alpha-difluoromethylornithine and standard trypanocides.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

The treatment of human African trypanosomiasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

Cultivation in a semi-defined medium of animal infective forms of Trypanosoma brucei, T. equiperdum, T. evansi, T. rhodesiense and T. gambiense

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

Human drug metabolism in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

Effects of the ornithine decarboxylase inhibitors DL-alpha-difluoromethylornithine and alpha-monofluoromethyldehydroornithine methyl ester alone and in combination with suramin against Trypanosoma brucei brucei central nervous system models.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

Cultivation of Parasites in Vitro *

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 July 2018

Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 October 2018

Nifurtimox-eflornithine combination therapy for second-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Congo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 October 2018

AN-2690, a novel antifungal for the topical treatment of onychomycosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 October 2018

Optimizing classification of drug-drug interaction potential for CYP450 isoenzyme inhibition assays in early drug discovery.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 October 2018

Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 October 2018

Steady-state brain concentrations of antihistamines in rats: interplay of membrane permeability, P-glycoprotein efflux and plasma protein binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 October 2018

Human African trypanosomiasis: potential therapeutic benefits of an alternative suramin and melarsoprol regimen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 October 2018

GF120918, a P-glycoprotein modulator, increases the concentration of unbound amprenavir in the central nervous system in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 October 2018

Long-term exposure of Trypanosoma brucei gambiense to pentamidine in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 October 2018

Relapsed parasitaemia following chemotherapy of chronic T. brucei infections in mice and its relation to cerebral trypanosomes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

28 October 2018

Human African trypanosomiasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944573

9 December 2018

Time-dose-response of Trypanosoma brucei brucei to diminazene aceturate (Berenil) and in vitro simulation of drug-concentration-time profiles in cattle plasma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20660666

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological parameters in laboratory animals and humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/20660666

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/20660666

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.00498-10

1 reference

Europe PubMed Central

31 July 2017

PMC publication ID

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Europe PubMed Central

31 July 2017

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Europe PubMed Central

31 July 2017

ResearchGate publication ID

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