(Q73883565)

English

Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium

scientific article published on 01 August 2003

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scholarly article

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12948019%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12948019%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

author name string

Matthew D Troutman

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12948019%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

Dhiren R Thakker

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12948019%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

publication date

1 August 2003

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12948019%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

Pharmaceutical Research

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12948019%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

20

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12948019%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

8

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12948019%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1210-1224

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12948019%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

Saturable transport of H2-antagonists ranitidine and famotidine across Caco-2 cell monolayers

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug binding sites on P-glycoprotein are altered by ATP binding prior to nucleotide hydrolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: a survey of twenty cell lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a polarized efflux system in CACO-2 cells capable of modulating cyclosporin A transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-glycoprotein transporters and the gastrointestinal tract: evaluation of the potential in vivo relevance of in vitro data employing talinolol as model compound.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simulated intestinal fluid as transport medium in the Caco-2 cell culture model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a novel route of extraction of sirolimus in human small intestine: roles of metabolism and secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased systemic toxicity of sarcoma chemotherapy due to combination with the P-glycoprotein inhibitor cyclosporin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane fluidity and transport properties in epithelia

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transepithelial transport of drugs by the multidrug transporter in cultured Madin-Darby canine kidney cell epithelia

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug exsorption from blood into the gastrointestinal tract

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible involvement of multiple P-glycoprotein-mediated efflux systems in the transport of verapamil and other organic cations across rat intestine

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological insights from P-glycoprotein knockout mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Asymmetry of plasma membrane lipid order in Madin-Darby Canine Kidney cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of mdr1a P-glycoprotein in the biliary and intestinal secretion of doxorubicin and vinblastine in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intestinal secretion of intravenous talinolol is inhibited by luminal R-verapamil

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the human multidrug transporter in insect cells by a recombinant baculovirus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rational use of in vitro P-glycoprotein assays in drug discovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allosteric regulation of [3H]vinblastine binding to P-glycoprotein of MCF-7 ADR cells by dexniguldipine

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum)

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of P-glycoprotein-mediated secretion in absorptive drug permeability: An approach using passive membrane permeability and affinity to P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Madin Darby canine kidney (MDCK) epithelial cell monolayer as a model cellular transport barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contributions of hepatic and intestinal metabolism and P-glycoprotein to cyclosporine and tacrolimus oral drug delivery

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic and pharmacodynamic implications of P-glycoprotein modulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of passive permeability on apparent P-glycoprotein kinetics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell surface polarity in epithelia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of P-glycoprotein in limiting intestinal regional absorption of digoxin in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for intestinal secretion as an additional clearance pathway of talinolol enantiomers: concentration- and dose-dependent absorption in vitro and in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of the P-glycoprotein, the multidrug transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid sorting in epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modeling of P-glycoprotein-involved epithelial drug transport in MDCK cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered pharmacokinetics of vinblastine in Mdr1a P-glycoprotein-deficient Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-glycoprotein-mediated renal tubular secretion of digoxin: the toxicological significance of the urine-blood barrier model

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of intestinal P-glycoprotein in the restricted absorption of methylprednisolone from rat small intestine

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-directed fluorescence labeling of P-glycoprotein on cysteine residues in the nucleotide binding domains.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of P-glycoprotein-mediated efflux of paclitaxel

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential role of P-glycoprotein in affecting hepatic metabolism of drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein measurement with the Folin phenol reagent

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A biophysical model of passive and polarized active transport processes in Caco-2 cells: approaches to uncoupling apical and basolateral membrane events in the intact cell.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of P-glycoprotein mediated transport of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor, across MDR1-MDCK and Caco-2 cell monolayers

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rhodamine 123 requires carrier-mediated influx for its activity as a P-glycoprotein substrate in Caco-2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The multi-drug resistance reversal agent SR33557 and modulation of vinca alkaloid binding to P-glycoprotein by an allosteric interaction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Communication between multiple drug binding sites on P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of hydroxyzine on the transport of etoposide in rat small intestine

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct demonstration of small intestinal secretion and site-dependent absorption of the beta-blocker talinolol in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1023/A:1025001131513

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12948019%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12948019%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

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