(Q44568338)

English

Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers

scientific article published in August 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

1 reference

based on heuristic

inferred from title

author name string

Matthew D Troutman

1

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Dhiren R Thakker

2

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

publication date

1 August 2003

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Pharmaceutical Research

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

20

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

1200-1209

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Saturable transport of H2-antagonists ranitidine and famotidine across Caco-2 cell monolayers

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-glycoprotein transporters and the gastrointestinal tract: evaluation of the potential in vivo relevance of in vitro data employing talinolol as model compound.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-glycoprotein does not reduce substrate concentration from the extracellular leaflet of the plasma membrane in living cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Digoxin interactions. The influence of quinidine and verapamil on the pharmacokinetics and receptor binding of digitalis glycosides

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro substrate identification studies for p-glycoprotein-mediated transport: species difference and predictability of in vivo results

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug exsorption from blood into the gastrointestinal tract

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible involvement of multiple P-glycoprotein-mediated efflux systems in the transport of verapamil and other organic cations across rat intestine

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological insights from P-glycoprotein knockout mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Asymmetry of plasma membrane lipid order in Madin-Darby Canine Kidney cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of mdr1a P-glycoprotein in the biliary and intestinal secretion of doxorubicin and vinblastine in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rational use of in vitro P-glycoprotein assays in drug discovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improved inhibitors of glucosylceramide synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of lipid polarity in intestinal epithelial (Caco-2) cells: sphingolipid synthesis in the Golgi complex and sorting before vesicular traffic to the plasma membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum)

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intestinal transport of irinotecan in Caco-2 cells and MDCK II cells overexpressing efflux transporters Pgp, cMOAT, and MRP1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contributions of hepatic and intestinal metabolism and P-glycoprotein to cyclosporine and tacrolimus oral drug delivery

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic and pharmacodynamic implications of P-glycoprotein modulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of passive permeability on apparent P-glycoprotein kinetics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of the coumarinic acid-based cyclic prodrug of the opioid peptide DADLE.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The contribution of P-glycoprotein to pharmacokinetic drug-drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of P-glycoprotein in limiting intestinal regional absorption of digoxin in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for intestinal secretion as an additional clearance pathway of talinolol enantiomers: concentration- and dose-dependent absorption in vitro and in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unidirectional fluxes of rhodamine 123 in multidrug-resistant cells: evidence against direct drug extrusion from the plasma membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid sorting in epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modeling of P-glycoprotein-involved epithelial drug transport in MDCK cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered pharmacokinetics of vinblastine in Mdr1a P-glycoprotein-deficient Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of intestinal P-glycoprotein in the restricted absorption of methylprednisolone from rat small intestine

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A biophysical model of passive and polarized active transport processes in Caco-2 cells: approaches to uncoupling apical and basolateral membrane events in the intact cell.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two strains of the Madin-Darby canine kidney (MDCK) cell line have distinct glycosphingolipid compositions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rhodamine 123 requires carrier-mediated influx for its activity as a P-glycoprotein substrate in Caco-2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluorescent cellular indicators are extruded by the multidrug resistance protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of hydroxyzine on the transport of etoposide in rat small intestine

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct demonstration of small intestinal secretion and site-dependent absorption of the beta-blocker talinolol in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/12948018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1023/A:1025049014674

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

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