(Q34155571)

31 July 2017

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title

Protein kinases as therapeutic targets (English)

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31 July 2017

Sridhar R

1

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PubMed ID

11205726

31 July 2017

Hanson-Painton O

series ordinal

2

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PubMed ID

11205726

31 July 2017

Cooper DR

series ordinal

3

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31 July 2017

1 November 2000

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31 July 2017

Pharmaceutical Research

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31 July 2017

17

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31 July 2017

1345-1353

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31 July 2017

11

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Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

31 July 2017

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12 December 2020

UCN-01 abrogates G2 arrest through a Cdc2-dependent pathway that is associated with inactivation of the Wee1Hu kinase and activation of the Cdc25C phosphatase.

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12 December 2020

H-ras and raf-1 cooperate in transformation of NIH3T3 fibroblasts

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12 December 2020

Activation of raf-1, MEK, and MAP kinase in prolactin responsive mammary cells

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12 December 2020

Protein modules and signalling networks

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12 December 2020

Interleukin-6 induces prostate cancer cell growth accompanied by activation of stat3 signaling pathway .

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12 December 2020

Protein kinase C: structure, function, and regulation

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12 December 2020

DNA end-joining catalyzed by human cell-free extracts

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12 December 2020

Regulation of alternative splicing of protein kinase C beta by insulin

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12 December 2020

ZD4190: an orally active inhibitor of vascular endothelial growth factor signaling with broad-spectrum antitumor efficacy

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12 December 2020

The roles of 14-3-3 proteins in signal transduction.

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12 December 2020

Adenoma-specific alterations of protein kinase C isozyme expression in Apc(MIN) mice

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12 December 2020

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

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12 December 2020

Preclinical and clinical pharmacology of antisense oligonucleotides

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12 December 2020

Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling

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12 December 2020

Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis

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12 December 2020

Factors affecting the activity of muscle phosphorylase b kinase

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12 December 2020

1001 protein kinases redux--towards 2000.

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12 December 2020

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

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12 December 2020

Signal transduction by receptors with tyrosine kinase activity

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12 December 2020

The mutationally activated Met receptor mediates motility and metastasis

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12 December 2020

Tyrosine kinase inhibition: an approach to drug development

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12 December 2020

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

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12 December 2020

Ceramide activates the stress-activated protein kinases

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12 December 2020

Signal perception and transduction: the role of protein kinases

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12 December 2020

Protein phosphorylation and signal transduction

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12 December 2020

Structure of DNA-dependent protein kinase: implications for its regulation by DNA.

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12 December 2020

Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification

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12 December 2020

Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells).

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12 December 2020

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12 December 2020

The DNA-dependent protein kinase

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12 December 2020

Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth

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12 December 2020

HER-2/neu signal transduction in human breast and ovarian cancer

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12 December 2020

Prolonged activation of the mitogen-activated protein kinase pathway is required for macrophage-like differentiation of a human myeloid leukemic cell line.

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12 December 2020

Form, function, and regulation of protein tyrosine phosphatases and their involvement in human diseases.

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12 December 2020

MAPKs: new JNK expands the group

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12 December 2020

Phosphoinositide kinases

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12 December 2020

ALK expression defines a distinct group of T/null lymphomas ("ALK lymphomas") with a wide morphological spectrum.

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12 December 2020

Flk-1 as a target for tumor growth inhibition.

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12 December 2020

Inhibition of apoptotic signaling pathways in cancer cells as a mechanism of chemotherapy resistance

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12 December 2020

In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C.

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12 December 2020

Role for ceramide in cell cycle arrest.

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12 December 2020

Diabetic vascular dysfunctions: a model of excessive activation of protein kinase C.

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12 December 2020

Antiapoptotic signaling in LNCaP prostate cancer cells: a survival signaling pathway independent of phosphatidylinositol 3'-kinase and Akt/protein kinase B.

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12 December 2020

Growth inhibition of human tumor cells in athymic mice by anti-epidermal growth factor receptor monoclonal antibodies

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12 December 2020

A carboxy-terminal deletion mutant of protein kinase C beta II inhibits insulin-stimulated 2-deoxyglucose uptake in L6 rat skeletal muscle cells

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12 December 2020

Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha

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12 December 2020

Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs

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12 December 2020

Amphiregulin antisense oligonucleotide inhibits the growth of T3M4 human pancreatic cancer cells and sensitizes the cells to EGF receptor-targeted therapy.

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12 December 2020

The DNA-activated protein kinase -- DNA-PK

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12 December 2020

Antiestrogens: clinical applications of pharmacology

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12 December 2020

Protein kinase C activation and the development of diabetic complications

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12 December 2020

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

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12 December 2020

Requirement for an interaction of XRCC4 with DNA ligase IV for wild-type V(D)J recombination and DNA double-strand break repair in vivo.

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12 December 2020

Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials

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12 December 2020

The epidermal growth factor receptor and its inhibition in cancer therapy

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12 December 2020

Identification of two essential phosphorylated threonine residues in the catalytic domain of Mekk1. Indirect activation by Pak3 and protein kinase C

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12 December 2020

TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis

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12 December 2020

Protein kinase C-delta mRNA is down-regulated transcriptionally and post-transcriptionally by 12-O-tetradecanoylphorbol-13-acetate

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12 December 2020

The protein kinases of budding yeast: six score and more

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12 December 2020

DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus

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12 December 2020

A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

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12 December 2020

Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts

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12 December 2020

On target with a new mechanism for the regulation of protein phosphorylation

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12 December 2020

DNA breakage and repair

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12 December 2020

Oncogenic activation of human R-ras by point mutations analogous to those of prototype H-ras oncogenes.

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12 December 2020

Inhibition of constitutively activated Stat3 signaling pathway suppresses growth of prostate cancer cells

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12 December 2020

Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

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12 December 2020

Non-invasive detection of fecal protein kinase C betaII and zeta messenger RNA: putative biomarkers for colon cancer

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12 December 2020

p53-dependent cell cycle control: response to genotoxic stress

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12 December 2020

Acute hyperglycemia regulates transcription and posttranscriptional stability of PKCbetaII mRNA in vascular smooth muscle cells.

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12 December 2020

STATs and gene regulation

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12 December 2020

The HER-2/neu oncogene in breast cancer: prognostic factor, predictive factor, and target for therapy.

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12 December 2020

'Zip codes' direct intracellular protein tyrosine phosphatases to the correct cellular 'address'.

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12 December 2020

Epidermal growth factor-related peptides and their receptors in human malignancies

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12 December 2020

Ectopic expression of protein kinase CbetaII, -delta, and -epsilon, but not -betaI or -zeta, provide for insulin stimulation of glucose uptake in NIH-3T3 cells

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12 December 2020

STAT proteins as novel targets for cancer therapy. Signal transducer an activator of transcription

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12 December 2020

Identifiers

DOI

10.1023/A:1007507224529

1 reference

31 July 2017

1 reference

PubMed ID

11205726