(Q34156513)

31 July 2017

title

Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer (English)

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31 July 2017

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31

Elisa de Stanchina

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Kwok Kin Wong

36

object named as

Kwok-Kin Wong

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31 July 2017

38

Marc Ladanyi

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31 July 2017

Qingguo Wang

32

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Gavin Wright

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Gavin M Wright

24

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William Pao

39

object named as

William Pao

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31 July 2017

1

Christine M Lovly

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31 July 2017

2

Nerina T McDonald

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31 July 2017

3

Heidi Chen

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31 July 2017

4

Sandra Ortiz-Cuaran

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31 July 2017

5

Lukas C Heukamp

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31 July 2017

6

Yingjun Yan

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31 July 2017

7

Alexandra Florin

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31 July 2017

8

Luka Ozretić

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31 July 2017

15

Ronglai Shen

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31 July 2017

18

Sascha Ansén

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31 July 2017

19

Sven Perner

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31 July 2017

29

Monica Red-Brewer

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31 July 2017

33

Zhongming Zhao

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31 July 2017

23

Masyar Gardizi

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31 July 2017

Diana Lim

9

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31 July 2017

Lu Wang

10

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31 July 2017

Zhao Chen

11

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31 July 2017

Xi Chen

12

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31 July 2017

Pengcheng Lu

13

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31 July 2017

Paul K Paik

14

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31 July 2017

Hailing Jin

16

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31 July 2017

Reinhard Buettner

17

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31 July 2017

Michael Brockmann

20

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31 July 2017

Marc Bos

21

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31 July 2017

Jürgen Wolf

22

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31 July 2017

Benjamin Solomon

25

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31 July 2017

Prudence A Russell

26

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31 July 2017

Toni-Maree Rogers

27

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31 July 2017

Yoshiyuki Suehara

28

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31 July 2017

Rudy Tieu

30

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David H Johnson

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Leora Horn

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31 July 2017

Roman K Thomas

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31 July 2017

language of work or name

English

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publication date

31 August 2014

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31 July 2017

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31 July 2017

volume

20

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31 July 2017

issue

9

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31 July 2017

page(s)

1027-1034

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describes a project that uses

31 July 2017

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/4159407

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Ceritinib in ALK-rearranged non-small-cell lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

IGF-1R/epithelial-to-mesenchymal transition (EMT) crosstalk suppresses the erlotinib-sensitizing effect of EGFR exon 19 deletion mutations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

ALK rearrangements are mutually exclusive with mutations in EGFR or KRAS: an analysis of 1,683 patients with non-small cell lung cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

Resistance to irreversible EGF receptor tyrosine kinase inhibitors through a multistep mechanism involving the IGF1R pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

Identification of KIF5B-RET and GOPC-ROS1 fusions in lung adenocarcinomas through a comprehensive mRNA-based screen for tyrosine kinase fusions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

Genome sequencing identifies a basis for everolimus sensitivity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

Activation of HER family signaling as a mechanism of acquired resistance to ALK inhibitors in EML4-ALK-positive non-small cell lung cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

Using tandem mass spectrometry in targeted mode to identify activators of class IA PI3K in cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

Targeting oncogenic ALK: a promising strategy for cancer treatment

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

A platform for rapid detection of multiple oncogenic mutations with relevance to targeted therapy in non-small-cell lung cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

The Sequence Alignment/Map format and SAMtools

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

Fast and accurate short read alignment with Burrows-Wheeler transform

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

Quantifying synergism/antagonism using nonlinear mixed-effects modeling: a simulation study

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

beadarray: R classes and methods for Illumina bead-based data.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4159407

Escaping ALK inhibition: mechanisms of and strategies to overcome resistance.

5 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.3667

Insulin receptor substrate regulation of phosphoinositide 3-kinase.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.3667

21 January 2018

Identifiers

DOI

10.1038/NM.3667

1 reference

31 July 2017

1 reference

31 July 2017

1 reference