(Q34172489)

31 July 2017

title

Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor (English)

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31 July 2017

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Mark J Mulvihill

1

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31 July 2017

Andrew Cooke

2

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31 July 2017

Maryland Rosenfeld-Franklin

3

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31 July 2017

Elizabeth Buck

4

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31 July 2017

Ken Foreman

5

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31 July 2017

Darla Landfair

6

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31 July 2017

Matthew O'Connor

7

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31 July 2017

Caroline Pirritt

8

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31 July 2017

Yingchaun Sun

9

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31 July 2017

Yan Yao

10

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31 July 2017

Lee D Arnold

11

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31 July 2017

Neil W Gibson

12

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31 July 2017

Qun-Sheng Ji

13

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31 July 2017

publication date

1 September 2009

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Future Medicinal Chemistry

31 July 2017

published in

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31 July 2017

volume

1

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31 July 2017

issue

6

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31 July 2017

page(s)

1153-1171

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Insulin-like growth factor 1 receptor targeted therapeutics: novel compounds and novel treatment strategies for cancer medicine

31 July 2017

cites work

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Insulin-like growth factors and neoplasia.

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Treatment of hematologic malignancies and solid tumors by inhibiting IGF receptor signaling

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Role of insulin-like growth factor 1 receptor signalling in cancer

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Type I insulin-like growth factor receptor as a therapeutic target in cancer

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Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: lessons from the first clinical trials

21 January 2018

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The therapeutic potential of agents targeting the type I insulin-like growth factor receptor

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Insulin-like growth factor-I receptor signaling blockade combined with radiation

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Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells

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Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin).

21 January 2018

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Insulin-like growth factor (IGF)-I rescues breast cancer cells from chemotherapy-induced cell death--proliferative and anti-apoptotic effects

21 January 2018

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Insulin-like growth factor-I receptor signalling and acquired resistance to gefitinib (ZD1839; Iressa) in human breast and prostate cancer cells

21 January 2018

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Insulin-like growth factor-I receptor signaling in tamoxifen-resistant breast cancer: a supporting role to the epidermal growth factor receptor.

21 January 2018

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Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells

21 January 2018

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Hyperactivation of the insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells

21 January 2018

1 reference

Inhibition of insulin-like growth factor-I receptor (IGF-IR) signaling and tumor cell growth by a fully human neutralizing anti-IGF-IR antibody

21 January 2018

1 reference

Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871.

21 January 2018

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A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts

21 January 2018

1 reference

Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer

21 January 2018

1 reference

Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an orally efficacious inhibitor of insulin-like growth factor-1 receptor

21 January 2018

1 reference

The type 1 insulin-like growth factor receptor pathway

21 January 2018

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1,3-Disubstituted-imidazo[1,5-a]pyrazines as insulin-like growth-factor-I receptor (IGF-IR) inhibitors.

21 January 2018

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A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo

21 January 2018

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Novel 2-phenylquinolin-7-yl-derived imidazo[1,5-a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors

21 January 2018

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Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

21 January 2018

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The insulin receptor is essential for virus-induced tumorigenesis of Kaposi's sarcoma

21 January 2018

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Insulin receptor isoform A and insulin-like growth factor II as additional treatment targets in human osteosarcoma.

21 January 2018

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In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A.

21 January 2018

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Autocrine/paracrine involvement of insulin-like growth factor-I and its receptor in chronic lymphocytic leukaemia.

21 January 2018

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Insulin receptor expression by human prostate cancers

21 January 2018

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Insulin and insulin-like growth factor signalling in neoplasia

21 January 2018

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Targeting insulin and insulin-like growth factor signalling in oncology

21 January 2018

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Differential roles of the insulin and insulin-like growth factor-I (IGF-I) receptors in response to insulin and IGF-I.

21 January 2018

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Disruption of the insulin-like growth factor type 1 receptor in osteoblasts enhances insulin signaling and action.

21 January 2018

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OSI-930: a novel selective inhibitor of Kit and kinase insert domain receptor tyrosine kinases with antitumor activity in mouse xenograft models

21 January 2018

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Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development

21 January 2018

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21 January 2018

Identifiers

DOI

10.4155/FMC.09.89

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31 July 2017

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