(Q36185627)

12 August 2017

1 reference

title

Treatment of hematologic malignancies and solid tumors by inhibiting IGF receptor signaling (English)

1 reference

12 August 2017

author name string

Constantine S Mitsiades

series ordinal

1

1 reference

12 August 2017

Nicholas Mitsiades

series ordinal

2

1 reference

12 August 2017

publication date

1 June 2005

1 reference

Expert Review of Anticancer Therapy

12 August 2017

published in

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12 August 2017

volume

5

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12 August 2017

issue

3

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12 August 2017

page(s)

487-499

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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

12 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

21 January 2018

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EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

21 January 2018

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

21 January 2018

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The role of erlotinib (Tarceva, OSI 774) in the treatment of non-small cell lung cancer

21 January 2018

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EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Structure and function of the type 1 insulin-like growth factor receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Structure and function of the insulin-like growth factor I receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Structural biology of insulin and IGF1 receptors: implications for drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Elevated insulin receptor content in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Functional insulin receptors are overexpressed in thyroid tumors: is this an early event in thyroid tumorigenesis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Insulin-like growth factor receptors and binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Insulin-like growth factor (IGF) binding protein from human decidua inhibits the binding and biological action of IGF-I in cultured choriocarcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Insulin-like growth factor II stimulates cell proliferation through the insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Loss of heterozygosity at the mannose 6-phosphate insulin-like growth factor 2 receptor gene correlates with poor differentiation in early breast carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

M6P/IGF2R is mutated in squamous cell carcinoma of the lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Expression of insulin-like growth factor 1 receptor in primary breast cancer: immunohistochemical analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Chemosensitization of human prostate cancer using antisense agents targeting the type 1 insulin-like growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Expression of tyrosine kinases in human malignancies as potential targets for kinase-specific inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Growth factor receptors as therapeutic targets: strategies to inhibit the insulin-like growth factor I receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

The insulin-like growth factor system and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

The insulin-like growth factor I receptor gene is the target for the 15q26 amplicon in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Insulin-like growth factors and neoplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Regulation of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in thyroid carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Regulation of Vascular Endothelial Growth Factor Expression by Insulin-Like Growth Factor I in Thyroid Carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

A dominant negative type I insulin-like growth factor receptor inhibits metastasis of human cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Mechanisms of regulation of cell adhesion and motility by insulin receptor substrate-1 in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Regulation of breast cancer cell motility by insulin receptor substrate-2 (IRS-2) in metastatic variants of human breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

A phase I trial of a Bcl-2 antisense (G3139) and weekly docetaxel in patients with advanced breast cancer and other solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Growth regulation of human glioblastoma T98G cells by insulin-like growth factor-1 and its receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Inhibition of rat C6 glioblastoma tumor growth by expression of insulin-like growth factor I receptor antisense mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Activation of the IGF-IR system contributes to malignant growth of human and mouse medulloblastomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Inhibition of in vivo breast cancer growth by antisense oligodeoxynucleotides to type I insulin-like growth factor receptor mRNA involves inactivation of ErbBs, PI-3K/Akt and p42/p44 MAPK signaling pathways but not modulation of progesterone recepto

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insulin-like growth factor receptor in mammary tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Effectiveness of insulin-like growth factor I receptor antisense strategy against Ewing's sarcoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Inhibition of carcinoma cell growth and metastasis by a vesicular stomatitis virus G-pseudotyped retrovector expressing type I insulin-like growth factor receptor antisense

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Distribution and characterization of insulin and insulin-like growth factor I receptors in normal human ovary.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Two new monoclonal antibodies against the alpha subunit of the human insulin-like growth factor-I receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Insulin-like growth factors modulate the growth inhibitory effects of retinoic acid on MCF-7 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

ASPB10 insulin induction of increased mitogenic responses and phenotypic changes in human breast epithelial cells: evidence for enhanced interactions with the insulin-like growth factor-I receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Insulinlike growth factor I: a potent mitogen for human osteogenic sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Redundancy of autocrine loops in human osteosarcoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Molecular sequelae of proteasome inhibition in human multiple myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Effect of endocrine therapy on growth of T61 human breast cancer xenografts is directly correlated to a specific down-regulation of insulin-like growth factor II (IGF-II).

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Simultaneous blockade of both the epidermal growth factor receptor and the insulin-like growth factor receptor signaling pathways in cancer cells with a fully human recombinant bispecific antibody.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Single-chain antibodies against human insulin-like growth factor I receptor: expression, purification, and effect on tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Substrate competitive inhibitors of IGF-1 receptor kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Development of new insulin-like growth factor-1 receptor kinase inhibitors using catechol mimics

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Recombinant insulin-like growth factor binding protein-1 inhibits IGF-I, serum, and estrogen-dependent growth of MCF-7 human breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-beta1 on programmed cell death through a p53- and IGF-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Insulin-like growth factor-binding protein 3 induces caspase-dependent apoptosis through a death receptor-mediated pathway in MCF-7 human breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Polyethylene glycol conjugated insulin-like growth factor binding protein-1 (IGFBP-1) inhibits growth of breast cancer in athymic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Antitumor activity of the growth hormone receptor antagonist pegvisomant against human meningiomas in nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Combination of somatostatin analog, dexamethasone, and standard androgen ablation therapy in stage D3 prostate cancer patients with bone metastases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

The role of the insulin-like growth factor-I receptor in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

Functional Polymorphism in the Parental Imprinting of the Human IGF2R Gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.5.3.487

21 January 2018

Identifiers

DOI

10.1586/14737140.5.3.487

1 reference

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Fatcat ID

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Fatcat

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mapped directly with Wikidata item

30 July 2022

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1 reference