(Q34162807)

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Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells

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25 December 2019

Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells (English)

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25 December 2019

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Kuzhuvelil B Harikumar

1

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25 December 2019

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Ajaikumar B Kunnumakkara

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25 December 2019

Kwang S Ahn

3

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25 December 2019

Preetha Anand

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25 December 2019

Sunil Krishnan

5

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25 December 2019

Sushovan Guha

6

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25 December 2019

Bharat B Aggarwal

7

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25 December 2019

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publication date

24 October 2008

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25 December 2019

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11

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25 December 2019

113

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25 December 2019

9

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25 December 2019

2003-2013

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25 December 2019

Xanthohumol inhibits inflammatory factor production and angiogenesis in breast cancer xenografts.

1 reference

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Natural and non-natural prenylated chalcones: synthesis, cytotoxicity and anti-oxidative activity

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Nuclear factor-kappaB activation: from bench to bedside

1 reference

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Inhibition of topoisomerase I activity and efflux drug transporters' expression by xanthohumol. from hops

1 reference

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5 July 2018

Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis

1 reference

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5 July 2018

Treatment of PC-3 and DU145 prostate cancer cells by prenylflavonoids from hop (Humulus lupulus L.) induces a caspase-independent form of cell death

1 reference

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Modulation of breast cancer cell survival by aromatase inhibiting hop (Humulus lupulus L.) flavonoids

1 reference

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5 July 2018

Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products.

1 reference

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Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis.

1 reference

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5 July 2018

Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation

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5 July 2018

Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemot

1 reference

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5 July 2018

Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells

1 reference

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5 July 2018

From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer.

1 reference

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5 July 2018

Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-kappaB and Akt as targets

1 reference

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Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity.

1 reference

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5 July 2018

Xanthohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-A(y) mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947354

5 July 2018

Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947354

5 July 2018

Xanthohumol induces apoptosis in cultured 40-16 human colon cancer cells by activation of the death receptor- and mitochondrial pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947354

5 July 2018

Antiinvasive effect of xanthohumol, a prenylated chalcone present in hops (Humulus lupulus L.) and beer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947354

5 July 2018

Enhanced antitumor activity of xanthohumol, a diacylglycerol acyltransferase inhibitor, under hypoxia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947354

5 July 2018

Nuclear factor-kappaB: the enemy within

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947354

5 July 2018

Nitric oxide represses inhibitory kappaB kinase through S-nitrosylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947354

5 July 2018

The chalcone xanthohumol inhibits triglyceride and apolipoprotein B secretion in HepG2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947354

5 July 2018

Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947354

5 July 2018

Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947354

5 July 2018

Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947354

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Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947354

5 July 2018

Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947354

5 July 2018

Quantitative analysis of xanthohumol and related prenylflavonoids in hops and beer by liquid chromatography-tandem mass spectrometry

1 reference

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1 reference

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Bone resorption inhibitors from hop extract

1 reference

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1 reference

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1 reference

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Xanthohumol kills B-chronic lymphocytic leukemia cells by an apoptotic mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947354

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A safety study of oral xanthohumol administration and its influence on fertility in Sprague Dawley rats.

1 reference

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1 reference

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1 reference

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1 reference

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Formation of adducts of parthenin and related sesquiterpene lactones with cysteine and glutathione

1 reference

https://pubmed.ncbi.nlm.nih.gov/18952893

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Helenanolide-type sesquiterpene lactones--III. Rates and stereochemistry in the reaction of helenalin and related helenanolides with sulfhydryl containing biomolecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/18952893

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus

1 reference

https://pubmed.ncbi.nlm.nih.gov/18952893

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue

1 reference

https://pubmed.ncbi.nlm.nih.gov/18952893

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor (EGF) activates nuclear factor-kappaB through IkappaBalpha kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IkappaBalpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/18952893

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cysteine-179 of IkappaB kinase beta plays a critical role in enzyme activation by promoting phosphorylation of activation loop serines

1 reference

https://pubmed.ncbi.nlm.nih.gov/18952893

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus

1 reference

https://pubmed.ncbi.nlm.nih.gov/18952893

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1182/BLOOD-2008-04-151944

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Europe PubMed Central

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25 December 2019

1 reference

Europe PubMed Central

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25 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18952893%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

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