(Q40290173)

English

Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemot

scientific article published on 19 April 2006

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemot (English)

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

1 reference

ChEBI release 2020-05-28

1 reference

based on heuristic

inferred from title

apoptotic process

1 reference

based on heuristic

inferred from title

author name string

Santosh K Sandur

1

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Haruyo Ichikawa

2

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Gautam Sethi

3

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Kwang Seok Ahn

4

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Bharat B Aggarwal

5

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

language of work or name

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publication date

19 April 2006

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

number of pages

11

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based on heuristic

inferred from page(s)

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

281

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

25

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

17023-17033

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Antioxidant properties of Plumbago zeylanica, an Indian medicinal plant and its active ingredient, plumbagin

1 reference

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21 January 2018

Cytotoxic action of juglone and plumbagin: a mechanistic study using HaCaT keratinocytes

1 reference

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21 January 2018

Synthesis of plumbagin derivatives and their inhibitory activities against Ehrlich ascites carcinoma in vivo and Leishmania donovani Promastigotes in vitro

1 reference

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21 January 2018

Effect of Plumbagin on some glucose metabolising enzymes studied in rats in experimental hepatoma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

Inhibitory effects of plumbagin and juglone on azoxymethane-induced intestinal carcinogenesis in rats.

1 reference

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21 January 2018

Long-patch base excision repair of apurinic/apyrimidinic site DNA is decreased in mouse embryonic fibroblast cell lines treated with plumbagin: involvement of cyclin-dependent kinase inhibitor p21Waf-1/Cip-1.

1 reference

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21 January 2018

Antisense blocking of BRCA1 enhances sensitivity to plumbagin but not tamoxifen in BG-1 ovarian cancer cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

Plumbagin induces reactive oxygen species, which mediate apoptosis in human cervical cancer cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

Nuclear factor-kappaB: the enemy within

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2.

1 reference

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21 January 2018

Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-kappaB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-kappaB-regulated gene expression and up-regulation of apoptosis

1 reference

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21 January 2018

Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein

1 reference

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21 January 2018

Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity.

1 reference

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21 January 2018

Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

Evidence that receptor activator of nuclear factor (NF)-kappaB ligand can suppress cell proliferation and induce apoptosis through activation of a NF-kappaB-independent and TRAF6-dependent mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

Missing pieces in the NF-kappaB puzzle

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

Nuclear transcription factor-kappaB as a target for cancer drug development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

Activators and target genes of Rel/NF-kappaB transcription factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

Inducible phosphorylation of I kappa B alpha is not sufficient for its dissociation from NF-kappa B and is inhibited by protease inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

Studies into the effect of the tyrosine kinase inhibitor herbimycin A on NF-kappa B activation in T lymphocytes. Evidence for covalent modification of the p50 subunit

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

ch-IAP1, a member of the inhibitor-of-apoptosis protein family, is a mediator of the antiapoptotic activity of the v-Rel oncoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

Anti-apoptotic protein survivin plays a significant role in tubular morphogenesis of human coronary arteriolar endothelial cells by hypoxic preconditioning

1 reference

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21 January 2018

Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

Protein kinase C-zeta regulates transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-alpha in glioma cells via NF-kappa B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras.

1 reference

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21 January 2018

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

1 reference

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21 January 2018

Role of collagenases in tumor cell invasion

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21 January 2018

Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase

1 reference

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21 January 2018

Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity

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21 January 2018

Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601595200

21 January 2018

Differential IκB Kinase Activation and IκBα Degradation by Interleukin-1β and Tumor Necrosis Factor-α in Human U937 Monocytic Cells

1 reference

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21 January 2018

Modification of bone marrow radiosensensitivity by medicinal plant extracts

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12 April 2024

https://opencitations.net/index/api/v1/citations/10.1259/BJR.70.834.9227253

Identifiers

10.1074/JBC.M601595200

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

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