(Q40565710)

English

Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-kappaB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-kappaB-regulated gene expression and up-regulation of apoptosis

scientific article published on 16 April 2004

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scholarly article

1 reference

Europe PubMed Central

21 September 2017

Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-kappaB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-kappaB-regulated gene expression and up-regulation of apoptosis (English)

1 reference

Europe PubMed Central

21 September 2017

1 reference

based on heuristic

inferred from title

2

object named as

Fadlo R Khuri

1 reference

Europe PubMed Central

21 September 2017

author name string

Yasunari Takada

1

1 reference

Europe PubMed Central

21 September 2017

Bharat B Aggarwal

3

1 reference

Europe PubMed Central

21 September 2017

language of work or name

0 references

publication date

16 April 2004

1 reference

Europe PubMed Central

21 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

21 September 2017

279

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Europe PubMed Central

21 September 2017

26287-26299

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Europe PubMed Central

21 September 2017

25

1 reference

Europe PubMed Central

21 September 2017

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

1 reference

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Inhibitors of Ras farnesyltransferases

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21 January 2018

Novel anticancer agents move closer to reality.

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21 January 2018

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

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21 January 2018

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice

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21 January 2018

Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development

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21 January 2018

Inhibitors of prenylation of Ras and other G-proteins and their application as therapeutics

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21 January 2018

Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects.

1 reference

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21 January 2018

Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells

1 reference

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21 January 2018

H-Ras-specific activation of NF-kappaB protects NIH 3T3 cells against stimulus-dependent apoptosis.

1 reference

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21 January 2018

Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras.

1 reference

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21 January 2018

Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation

1 reference

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21 January 2018

Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins

1 reference

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21 January 2018

Internalin B activates nuclear factor-kappa B via Ras, phosphoinositide 3-kinase, and Akt.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400963200

21 January 2018

Oncogenic Ras enhances NF-kappaB transcriptional activity through Raf-dependent and Raf-independent mitogen-activated protein kinase signaling pathways

1 reference

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21 January 2018

NF-kappa B is required for H-ras oncogene induced abnormal cell proliferation and tumorigenesis

1 reference

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21 January 2018

Protein kinase C-zeta regulates transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-alpha in glioma cells via NF-kappa B

1 reference

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21 January 2018

NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1.

1 reference

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21 January 2018

Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells

1 reference

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21 January 2018

Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation

1 reference

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21 January 2018

Genetic Deletion of the Tumor Necrosis Factor Receptor p60 or p80 Sensitizes Macrophages to Lipopolysaccharide-induced Nuclear Factor-κB, Mitogen-activated Protein Kinases, and Apoptosis

1 reference

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21 January 2018

Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase

1 reference

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21 January 2018

Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9.

1 reference

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21 January 2018

Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400963200

21 January 2018

Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression

1 reference

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21 January 2018

Missing pieces in the NF-kappaB puzzle

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400963200

21 January 2018

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400963200

21 January 2018

Activators and target genes of Rel/NF-kappaB transcription factors

1 reference

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21 January 2018

Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2.

1 reference

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21 January 2018

Mechanisms by which IkappaB proteins control NF-kappaB activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400963200

21 January 2018

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400963200

21 January 2018

NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400963200

21 January 2018

Anti-apoptotic protein survivin plays a significant role in tubular morphogenesis of human coronary arteriolar endothelial cells by hypoxic preconditioning

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400963200

21 January 2018

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400963200

21 January 2018

ch-IAP1, a member of the inhibitor-of-apoptosis protein family, is a mediator of the antiapoptotic activity of the v-Rel oncoprotein

1 reference

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21 January 2018

Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis.

1 reference

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21 January 2018

Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer

1 reference

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21 January 2018

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

1 reference

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21 January 2018

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis

1 reference

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21 January 2018

NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling

1 reference

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21 January 2018

Activation of nuclear factor-kappaB-dependent transcription by tumor necrosis factor-alpha is mediated through phosphorylation of RelA/p65 on serine 529.

1 reference

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21 January 2018

IkappaB kinase: beginning, not the end

1 reference

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21 January 2018

Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase kinase kinase (MEKK1).

1 reference

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21 January 2018

The essential role of MEKK3 in TNF-induced NF-kappaB activation

1 reference

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21 January 2018

Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336.

1 reference

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21 January 2018

Efficacy of SCH66336, a farnesyl transferase inhibitor, in conjunction with imatinib against BCR-ABL-positive cells

1 reference

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21 January 2018

Farnesyl transferase inhibitor SCH66336 is cytostatic, pro-apoptotic and enhances chemosensitivity to cisplatin in melanoma cells

1 reference

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21 January 2018

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400963200

21 January 2018

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400963200

21 January 2018

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400963200

21 January 2018

Differential IκB Kinase Activation and IκBα Degradation by Interleukin-1β and Tumor Necrosis Factor-α in Human U937 Monocytic Cells

1 reference

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21 January 2018

A cellular rescue team

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400963200

21 January 2018

Identifiers

10.1074/JBC.M400963200

1 reference

Europe PubMed Central

21 September 2017

1 reference

Europe PubMed Central

21 September 2017

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