(Q34165028)

31 July 2017

1 reference

title

Uracil in DNA--occurrence, consequences and repair (English)

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31 July 2017

1

Hans E Krokan

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31 July 2017

3

Geir Slupphaug

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31 July 2017

2

Finn Drabløs

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PubMed ID

12483510

31 July 2017

language of work or name

English

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publication date

1 December 2002

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31 July 2017

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31 July 2017

21

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31 July 2017

8935-8948

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31 July 2017

58

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205996

31 July 2017

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cites work

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

The alpha/beta fold uracil DNA glycosylases: a common origin with diverse fates

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Characterization of the substrate specificity of a human 5-hydroxymethyluracil glycosylase activity

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7 January 2021

Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Crystal structure of a thwarted mismatch glycosylase DNA repair complex

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Ultrasensitive and specific detection methods for exocylic DNA adducts: markers for lipid peroxidation and oxidative stress

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Mutagenic and genotoxic effects of three vinyl chloride-induced DNA lesions: 1,N6-ethenoadenine, 3,N4-ethenocytosine, and 4-amino-5-(imidazol-2-yl)imidazole.

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7 January 2021

The Pfam protein families database

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Role of MED1 (MBD4) Gene in DNA repair and human cancer

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

A kinetic analysis of substrate recognition by uracil-DNA glycosylase from herpes simplex virus type 1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Processivity of Escherichia coli and rat liver mitochondrial uracil-DNA glycosylase is affected by NaCl concentration

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Human mitochondrial uracil-DNA glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

5-Hydroxymethyluracil-DNA glycosylase activity may be a differentiated mammalian function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Human immunodeficiency virus type 1 Vpr protein binds to the uracil DNA glycosylase DNA repair enzyme

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

A specific mismatch repair event protects mammalian cells from loss of 5-methylcytosine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Uracil-DNA glycosylase acts by substrate autocatalysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

The mechanism of switching among multiple BER pathways.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Heteronuclear NMR and crystallographic studies of wild-type and H187Q Escherichia coli uracil DNA glycosylase: electrophilic catalysis of uracil expulsion by a neutral histidine 187

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Consensus sequences for good and poor removal of uracil from double stranded DNA by uracil-DNA glycosylase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Excision of uracil from double-stranded DNA by uracil-DNA glycosylase is sequence specific

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

A phylogenomic study of DNA repair genes, proteins, and processes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Urine 8-oxo-7,8-dihydro-2-deoxyguanosine vs. 5-(hydroxymethyl) uracil as DNA oxidation marker in adriamycin-treated patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

The replication-recombination connection: insights from genomics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

The role of leucine 191 of Escherichia coli uracil DNA glycosylase in the formation of a highly stable complex with the substrate mimic, ugi, and in uracil excision from the synthetic substrates

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

A 55-kDa protein isolated from human cells shows DNA glycosylase activity toward 3,N4-ethenocytosine and the G/T mismatch

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Targeting of human DNA polymerase iota to the replication machinery via interaction with PCNA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Separating substrate recognition from base hydrolysis in human thymine DNA glycosylase by mutational analysis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Thymine DNA glycosylase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Identification and characterization of a family of mammalian methyl-CpG binding proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Mammalian methyltransferases and methyl-CpG-binding domains: proteins involved in DNA methylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Protein structure comparison by alignment of distance matrices

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Mutagenic properties of the T-C cyclobutane dimer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Reconstructing the substrate for uracil DNA glycosylase: tracking the transmission of binding energy in catalysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Properties and functions of human uracil-DNA glycosylase from the UNG gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

DNA glycosylases in the base excision repair of DNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Site directed substitution of 5-hydroxymethyluracil for thymine in replicating phi X-174am3 DNA via synthesis of 5-hydroxymethyl-2'-deoxyuridine-5'-triphosphate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Instability and decay of the primary structure of DNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Structures of base pairs with 5-(hydroxymethyl)-2'-deoxyuridine in DNA determined by NMR spectroscopy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

The DNA glycosylase T:G mismatch-specific thymine DNA glycosylase represses thyroid transcription factor-1-activated transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Structure and activity of a thermostable thymine-DNA glycosylase: evidence for base twisting to remove mismatched normal DNA bases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Mutagenic potency of exocyclic DNA adducts: marked differences between Escherichia coli and simian kidney cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

SUMO, ubiquitin's mysterious cousin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Excision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil-DNA glycosylase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Sequence specificity for removal of uracil from U.A pairs and U.G mismatches by uracil-DNA glycosylase from Escherichia coli, and correlation with mutational hotspots

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localisation signal and a strong classical mitochondrial localisation signal, respectively

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Repair of chromosomal abasic sites in vivo involves at least three different repair pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Post-replicative base excision repair in replication foci

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Lessons learned from structural results on uracil-DNA glycosylase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

1H NMR studies of the 5-(hydroxymethyl)-2'-deoxyuridine containing TF1 binding site

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Assigning genomic sequences to CATH

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Structure and function in the uracil-DNA glycosylase superfamily

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Biphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Increased spontaneous mutation frequency in human cells expressing the phage PBS2-encoded inhibitor of uracil-DNA glycosylase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

RecA protein promotes the regression of stalled replication forks in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

An unexpectedly high excision capacity for mispaired 5-hydroxymethyluracil in human cell extracts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

3,N4-ethenocytosine, a highly mutagenic adduct, is a primary substrate for Escherichia coli double-stranded uracil-DNA glycosylase and human mismatch-specific thymine-DNA glycosylase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

A novel uracil-DNA glycosylase with broad substrate specificity and an unusual active site

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Biochemical characterization of uracil processing activities in the hyperthermophilic archaeon Pyrobaculum aerophilum

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

The structural basis of specific base-excision repair by uracil-DNA glycosylase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

A human enzyme that liberates uracil from DNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Mutation of an active site residue in Escherichia coli uracil-DNA glycosylase: effect on DNA binding, uracil inhibition and catalysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Properties of a Recombinant Human Uracil-DNA Glycosylase from the UNG Gene and Evidence that UNG Encodes the Major Uracil-DNA Glycosylase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Recombinational repair is critical for survival of Escherichia coli exposed to nitric oxide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Kinetic mechanism of damage site recognition and uracil flipping by Escherichia coli uracil DNA glycosylase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Sequence and time-dependent deamination of cytosine bases in UVB-induced cyclobutane pyrimidine dimers in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Transient accumulation of Okazaki fragments as a result of uracil incorporation into nascent DNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Retinoic acid receptors interact physically and functionally with the T:G mismatch-specific thymine-DNA glycosylase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Mechanism of stimulation of the DNA glycosylase activity of hOGG1 by the major human AP endonuclease: bypass of the AP lyase activity step

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Restriction, methylation and ligation of 5-hydroxymethyluracil-containing DNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Human thymine DNA glycosylase binds to apurinic sites in DNA but is displaced by human apurinic endonuclease 1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Thymine-DNA glycosylase and G to A transition mutations at CpG sites

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Stressing-out DNA? The contribution of serine-phosphodiester interactions in catalysis by uracil DNA glycosylase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Kinetic isotope effect studies of the reaction catalyzed by uracil DNA glycosylase: evidence for an oxocarbenium ion-uracil anion intermediate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Accumulation of small fragments of DNA in isolated HeLa cell nuclei due to transient incorporation of dUMP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Purification and determination of the NH2-terminal amino acid sequence of uracil-DNA glycosylase from human placenta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Presteady-state analysis of a single catalytic turnover by Escherichia coli uracil-DNA glycosylase reveals a "pinch-pull-push" mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

5-methylcytosine-DNA glycosylase activity is present in a cloned G/T mismatch DNA glycosylase associated with the chicken embryo DNA demethylation complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205996

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205996

1 reference

PubMed ID

12483510

Dimensions Publication ID

31 July 2017

0 references

1 reference

PubMed ID

12483510