(Q34166802)

31 July 2017

How Taxol/paclitaxel kills cancer cells. (English)

1 reference

31 July 2017

Beth A Weaver

1

1 reference

31 July 2017

1 September 2014

1 reference

Molecular Biology of the Cell

31 July 2017

1 reference

31 July 2017

25

1 reference

31 July 2017

18

1 reference

31 July 2017

2677-2681

1 reference

Intravital FRET imaging of tumor cell viability and mitosis during chemotherapy

31 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

The spindle assembly checkpoint

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Whole-genome studies identify solute carrier transporters in cellular susceptibility to paclitaxel

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Inhibitors targeting mitosis: tales of how great drugs against a promising target were brought down by a flawed rationale

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

The proliferation rate paradox in antimitotic chemotherapy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Phase I assessment of new mechanism-based pharmacodynamic biomarkers for MLN8054, a small-molecule inhibitor of Aurora A kinase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Welcome to a new kind of tension: translating kinetochore mechanics into a wait-anaphase signal

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Assessment of an RNA interference screen-derived mitotic and ceramide pathway metagene as a predictor of response to neoadjuvant paclitaxel for primary triple-negative breast cancer: a retrospective analysis of five clinical trials

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Evaluation of microtubule-associated protein-Tau expression as a prognostic and predictive marker in the NSABP-B 28 randomized clinical trial

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Live-cell analysis of mitotic spindle formation in taxol-treated cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Synthetic lethal screen identification of chemosensitizer loci in cancer cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Spindle checkpoint function and cellular sensitivity to antimitotic drugs

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Retention of paclitaxel in cancer cells for 1 week in vivo and in vitro

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Microtubule-associated protein tau: a marker of paclitaxel sensitivity in breast cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Microtubules as a target for anticancer drugs

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Mode of action of docetaxel - a basis for combination with novel anticancer agents

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Differential mitotic responses to microtubule-stabilizing and -destabilizing drugs

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Taxol suppresses dynamics of individual microtubules in living human tumor cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Localization of Mad2 to kinetochores depends on microtubule attachment, not tension

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

28 July 2018

Total synthesis of taxol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Camptothecin and taxol: discovery to clinic--thirteenth Bruce F. Cain Memorial Award Lecture

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Taxol induces the assembly of free microtubules in living cells and blocks the organizing capacity of the centrosomes and kinetochores

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Taxol stabilizes microtubules in mouse fibroblast cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Cytologic evidence that taxol, an antineoplastic agent from Taxus brevifolia, acts as a mitotic spindle poison

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Promotion of microtubule assembly in vitro by taxol

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

First total synthesis of taxol. 2. Completion of the C and D rings

28 July 2018

1 reference

https://api.crossref.org/works/10.1091%2FMBC.E14-04-0916

First total synthesis of taxol. 1. Functionalization of the B ring

21 January 2018

1 reference

https://api.crossref.org/works/10.1091%2FMBC.E14-04-0916

Mitosis is not a key target of microtubule agents in patient tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1091%2FMBC.E14-04-0916

On the road to cancer: aneuploidy and the mitotic checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1091%2FMBC.E14-04-0916

21 January 2018

1 reference

https://api.crossref.org/works/10.1091%2FMBC.E14-04-0916

Cyclin G1 regulates the outcome of taxane-induced mitotic checkpoint arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1091%2FMBC.E14-04-0916

Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1091%2FMBC.E14-04-0916

Cancer chemotherapy, biodiversity, public and private property: the case of the anti-cancer drug taxol

21 January 2018

1 reference

https://api.crossref.org/works/10.1091%2FMBC.E14-04-0916

From taxol to Taxol: the changing identities and ownership of an anti-cancer drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1091%2FMBC.E14-04-0916

Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

The billion dollar molecule: Taxol in historical and theoretical perspective.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4161504

Microtubule Crystals: A New Biophysical Phenomenon induced by Vinca Alkaloids

28 October 2018

1 reference

https://api.crossref.org/works/10.1091%2FMBC.E14-04-0916

Human polymorphonuclear leukocytes: demonstration of microtubules and effect of colchicine

21 January 2018

1 reference

12 December 2020

The spontaneous occurrence of apoptosis in squamous carcinomas of the uterine cervix

1 reference

12 December 2020

Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms

1 reference

12 December 2020

Kinetics of mitotic arrest and apoptosis in murine mammary and ovarian tumors treated with taxol

1 reference

12 December 2020

Intravenous paclitaxel is specifically retained in human gynecologic carcinoma tissues in vivo

1 reference

12 December 2020

Identifiers

DOI

10.1091/MBC.E14-04-0916

1 reference

31 July 2017

1 reference

31 July 2017

1 reference

PubMed ID

25213191