(Q34250840)

31 July 2017

title

Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles (English)

1 reference

31 July 2017

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1 reference

1 reference

Mark E Burkard

8

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Ronald T. Raines

object named as

Ronald T Raines

7

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author name string

Lauren M Zasadil

1

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31 July 2017

Kristen A Andersen

2

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31 July 2017

Dabin Yeum

3

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31 July 2017

Gabrielle B Rocque

4

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31 July 2017

Lee G Wilke

5

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31 July 2017

Amye J Tevaarwerk

6

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31 July 2017

Beth A Weaver

9

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31 July 2017

language of work or name

English

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publication date

1 March 2014

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Science Translational Medicine

31 July 2017

published in

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31 July 2017

volume

6

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31 July 2017

issue

229

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31 July 2017

page(s)

229ra43

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Intravital FRET imaging of tumor cell viability and mitosis during chemotherapy

31 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

The spindle assembly checkpoint

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

High mitotic activity of Polo-like kinase 1 is required for chromosome segregation and genomic integrity in human epithelial cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Inhibitors targeting mitosis: tales of how great drugs against a promising target were brought down by a flawed rationale

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Comparison of weekly versus every 3 weeks paclitaxel in the treatment of advanced solid tumors: a meta-analysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

A mechanism linking extra centrosomes to chromosomal instability

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Microtubules do not promote mitotic slippage when the spindle assembly checkpoint cannot be satisfied

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Mitotic drug targets and the development of novel anti-mitotic anticancer drugs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Targeted anti-mitotic therapies: can we improve on tubulin agents?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Spindle checkpoint function and cellular sensitivity to antimitotic drugs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Retention of paclitaxel in cancer cells for 1 week in vivo and in vitro

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

On the road to cancer: aneuploidy and the mitotic checkpoint

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Mad2 binding by phosphorylated kinetochores links error detection and checkpoint action in mitosis.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Taxol suppresses dynamics of individual microtubules in living human tumor cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Localization of Mad2 to kinetochores depends on microtubule attachment, not tension

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Golgi dispersal during microtubule disruption: regeneration of Golgi stacks at peripheral endoplasmic reticulum exit sites

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Analysis of spindle microtubule organization in untreated and taxol-treated PtK1 cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Taxol stabilizes microtubules in mouse fibroblast cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Phase I clinical and pharmacokinetic study of taxol.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Identification of novel centromere/kinetochore-associated proteins using monoclonal antibodies generated against human mitotic chromosome scaffolds

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

Promotion of microtubule assembly in vitro by taxol

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176609

From taxol to Taxol: the changing identities and ownership of an anti-cancer drug

6 July 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007965

Substoichiometric binding of taxol suppresses microtubule dynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007965

Mitosis is not a key target of microtubule agents in patient tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007965

Randomized study of paclitaxel and tamoxifen deposition into human brain tumors: implications for the treatment of metastatic brain tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007965

Aneuploidy acts both oncogenically and as a tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007965

Neoadjuvant concurrent paclitaxel and radiation in stage II/III breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007965

Tales of how great drugs were brought down by a flawed rationale--letter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007965

Tales of how great drugs were brought down by a flawed rationale--letter

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007965

Pharmacokinetics of paclitaxel and metabolites in a randomized comparative study in platinum-pretreated ovarian cancer patients

21 January 2018

1 reference

12 December 2020

Nonlinear pharmacokinetics and metabolism of paclitaxel and its pharmacokinetic/pharmacodynamic relationships in humans

1 reference

12 December 2020

Kinetics of mitotic arrest and apoptosis in murine mammary and ovarian tumors treated with taxol

1 reference

12 December 2020

Relationship of mitotic arrest and apoptosis to antitumor effect of paclitaxel

1 reference

12 December 2020

Centrosome defects and genetic instability in malignant tumors

1 reference

12 December 2020

Paclitaxel-induced apoptosis and mitotic arrest assessed by serial fine-needle aspiration: implications for early prediction of breast cancer response to neoadjuvant treatment

1 reference

12 December 2020

Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomas

1 reference

12 December 2020

The spontaneous occurrence of apoptosis in squamous carcinomas of the uterine cervix

1 reference

12 December 2020

10.1126/SCITRANSLMED.3007965

Identifiers

DOI

1 reference

31 July 2017

1 reference

31 July 2017

1 reference