(Q34174477)

English

A signaling cascade of nuclear calcium-CREB-ATF3 activated by synaptic NMDA receptors defines a gene repression module that protects against extrasynaptic NMDA receptor-induced neuronal cell death and ischemic brain damage.

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21451036%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

A signaling cascade of nuclear calcium-CREB-ATF3 activated by synaptic NMDA receptors defines a gene repression module that protects against extrasynaptic NMDA receptor-induced neuronal cell death and ischemic brain damage (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21451036%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

1 reference

based on heuristic

inferred from title

Roland Veltkamp

7

object named as

Roland Veltkamp

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21451036%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

author name string

Sheng-Jia Zhang

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21451036%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Bettina Buchthal

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21451036%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

David Lau

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21451036%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Stefanie Hayer

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21451036%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Oliver Dick

5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21451036%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Markus Schwaninger

6

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21451036%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Ming Zou

8

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21451036%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Ursula Weiss

9

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21451036%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Hilmar Bading

10

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21451036%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

language of work or name

0 references

publication date

1 March 2011

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21451036%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Journal of Neuroscience

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21451036%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

31

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21451036%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

13

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21451036%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

4978-4990

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21451036%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6622995/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Impaired phosphorylation of cyclic AMP response element binding protein in the hippocampus of dementia of the Alzheimer type.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lineages and transcription factors in the specification of vertebrate primary sensory neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal activity-dependent cell survival mediated by transcription factor MEF2

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription-dependent neuronal plasticity the nuclear calcium hypothesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional regulation by the phosphorylation-dependent factor CREB

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MEF2: a calcium-dependent regulator of cell division, differentiation and death

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disruption of CREB function in brain leads to neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Function and regulation of CREB family transcription factors in the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catalytic activity is required for calcium/calmodulin-dependent protein kinase IV to enter the nucleus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of cAMP-response-element-binding protein (CREB) after focal cerebral ischemia stimulates neurogenesis in the adult dentate gyrus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular pathways to neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microelectrode array recordings of cultured hippocampal networks reveal a simple model for transcription and protein synthesis-dependent plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal activation of NF-kappaB contributes to cell death in cerebral ischemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity-dependent neuroprotection and cAMP response element-binding protein (CREB): kinase coupling, stimulus intensity, and temporal regulation of CREB phosphorylation at serine 133.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear Ca2+ and the cAMP response element-binding protein family mediate a late phase of activity-dependent neuroprotection.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic dysfunction in Huntington's disease: a new perspective.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The many faces of CREB

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cAMP response element-binding protein regulates differentiation and survival of newborn neurons in the olfactory bulb.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IKK mediates ischemia-induced neuronal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulating Hox gene functions during animal body patterning

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arthropod segmentation: beyond the Drosophila paradigm

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A network dysfunction perspective on neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of Protein Tyrosine Phosphorylation by NMDA Receptor Activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decoding NMDA receptor signaling: identification of genomic programs specifying neuronal survival and death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Segmental patterning of the vertebrate embryonic axis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic activity-mediated suppression of p53 and induction of nuclear calcium-regulated neuroprotective genes promote survival through inhibition of mitochondrial permeability transition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear calcium signaling controls expression of a large gene pool: identification of a gene program for acquired neuroprotection induced by synaptic activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear calcium sensors reveal that repetition of trains of synaptic stimuli boosts nuclear calcium signaling in CA1 pyramidal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-methyl-D-aspartate receptors are critical for mediating the effects of glutamate on intracellular calcium concentration and immediate early gene expression in cultured hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fos: an immediate-early transcription factor in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic pathology of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional elimination of calmodulin within the nucleus by targeted expression of an inhibitor peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATF3 gene. Genomic organization, promoter, and regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective survival and activation of thymocytes in transgenic mice expressing a catalytically inactive form of Ca2+/calmodulin-dependent protein kinase IV

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CREB and memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of cocaine reward by CREB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21451036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.2672-10.2011

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21451036%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21451036%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21451036%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q34174477&oldid=1979654655"