(Q48029025)

English

Synaptic activity-mediated suppression of p53 and induction of nuclear calcium-regulated neuroprotective genes promote survival through inhibition of mitochondrial permeability transition.

scientific article published in April 2009

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357269%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Synaptic activity-mediated suppression of p53 and induction of nuclear calcium-regulated neuroprotective genes promote survival through inhibition of mitochondrial permeability transition (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357269%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

author name string

David Lau

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357269%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Hilmar Bading

2

1 reference

Europe PubMed Central

PMC publication ID

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25 January 2020

language of work or name

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publication date

1 April 2009

1 reference

Europe PubMed Central

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25 January 2020

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357269%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

29

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357269%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

14

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357269%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

4420-4429

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357269%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Control of recruitment and transcription-activating function of CBP determines gene regulation by NMDA receptors and L-type calcium channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Ca-calmodulin-dependent protein kinase cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis: checkpoint at the mitochondrial frontier.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excitotoxic mitochondrial depolarisation requires both calcium and nitric oxide in rat hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the p53 tumor suppressor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium-regulated protein kinase cascades and their transcription factor targets

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Compromised HOXA5 function can limit p53 expression in human breast tumours

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription-dependent neuronal plasticity the nuclear calcium hypothesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alteration of the Bcl-x/Bax ratio in a transgenic mouse model of amyotrophic lateral sclerosis: evidence for the implication of the p53 signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Surfing the p53 network

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis in neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca(2+)/CaM-dependent kinases: from activation to function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apaf-1 is a transcriptional target for E2F and p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PUMA induces the rapid apoptosis of colorectal cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PUMA, a novel proapoptotic gene, is induced by p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease is a synaptic failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 has a direct apoptogenic role at the mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntington's disease: a synaptopathy?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular Pathways of Neurodegeneration in Parkinson's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell death: critical control points

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CaMKII, an enzyme on the move: regulation of temporospatial localization

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium activation of ERK mediated by calmodulin kinase I.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cre-lox-regulated conditional RNA interference from transgenes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular pathways to neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microelectrode array recordings of cultured hippocampal networks reveal a simple model for transcription and protein synthesis-dependent plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity-dependent neuroprotection and cAMP response element-binding protein (CREB): kinase coupling, stimulus intensity, and temporal regulation of CREB phosphorylation at serine 133.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The p53 pathway: positive and negative feedback loops

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear Ca2+ and the cAMP response element-binding protein family mediate a late phase of activity-dependent neuroprotection.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prospective therapeutic applications of p53 inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 in neuronal apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptotic pathways: ten minutes to dead

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic dysfunction in Huntington's disease: a new perspective.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 tumor suppressor protein regulates the levels of huntingtin gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 and Ca2+ homeostasis in the endoplasmic reticulum

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adaptive roles of programmed cell death during nervous system development

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ALS: a disease of motor neurons and their nonneuronal neighbors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A network dysfunction perspective on neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of Protein Tyrosine Phosphorylation by NMDA Receptor Activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial membrane permeabilization in cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decoding NMDA receptor signaling: identification of genomic programs specifying neuronal survival and death

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 in health and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trinucleotide Repeat Disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 protein family members: versatile regulators of calcium signaling in cell survival and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell death during development of the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The nerve growth factor 35 years later

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunochemical localization of calcium/calmodulin-dependent protein kinase I.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional elimination of calmodulin within the nucleus by targeted expression of an inhibitor peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial dysfunction is a primary event in glutamate neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 expression induces apoptosis in hippocampal pyramidal neuron cultures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional repression of p53 promoter by hepatitis C virus core protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a calmodulin kinase II inhibitor protein in brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular characterization of mitochondrial apoptosis-inducing factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.0802-09.2009

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357269%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357269%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357269%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

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