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Very few substitutions in a germ line antibody are required to initiate significant domain exchange.
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Europe PubMed Central
PMC publication ID
2950590
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702640%20AND%20SRC:MED&resulttype=core&format=json
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9 February 2020
title
Very few substitutions in a germ line antibody are required to initiate significant domain exchange
(English)
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PMC publication ID
2950590
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retrieved
9 February 2020
main subject
antibody
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author
Michael Huber
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1
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2950590
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702640%20AND%20SRC:MED&resulttype=core&format=json
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9 February 2020
Katie Doores
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3
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2950590
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9 February 2020
Dennis R. Burton
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7
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Dennis R Burton
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2950590
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9 February 2020
author name string
Khoa M Le
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2
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2950590
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9 February 2020
Zara Fulton
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4
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2950590
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9 February 2020
Robyn L Stanfield
series ordinal
5
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2950590
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9 February 2020
Ian A Wilson
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6
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2950590
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9 February 2020
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English
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publication date
11 August 2010
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2950590
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retrieved
9 February 2020
published in
Journal of Virology
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PMC publication ID
2950590
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702640%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
volume
84
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2950590
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retrieved
9 February 2020
issue
20
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2950590
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retrieved
9 February 2020
page(s)
10700-10707
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2950590
reference URL
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retrieved
9 February 2020
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Antibody 2G12 Recognizes Di-Mannose Equivalently in Domain- and Nondomain-Exchanged Forms but Only Binds the HIV-1 Glycan Shield if Domain Exchanged
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Carbohydrate vaccines: developing sweet solutions to sticky situations?
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The role of antibodies in HIV vaccines
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Antibodies against Manalpha1,2-Manalpha1,2-Man oligosaccharide structures recognize envelope glycoproteins from HIV-1 and SIV strains
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Proline is not uniquely capable of providing the pivot point for domain swapping in 2G12, a broadly neutralizing antibody against HIV-1.
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28 July 2018
Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: implications for evasion of immune responses and design of vaccine immunogens
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Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target
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28 July 2018
An unfolded CH1 domain controls the assembly and secretion of IgG antibodies.
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28 July 2018
Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers
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28 July 2018
An oligosaccharide-based HIV-1 2G12 mimotope vaccine induces carbohydrate-specific antibodies that fail to neutralize HIV-1 virions
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PubMed Central
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28 July 2018
IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis
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Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning
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28 July 2018
Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates
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Deposition diseases and 3D domain swapping
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Toward oligosaccharide- and glycopeptide-based HIV vaccines.
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28 July 2018
Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12.
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28 July 2018
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28 July 2018
Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies
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28 July 2018
Electron microscopic and immunochemical analysis of the broadly neutralizing HIV-1-specific, anti-carbohydrate antibody, 2G12.
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28 July 2018
Antibody domain exchange is an immunological solution to carbohydrate cluster recognition
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28 July 2018
The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950590
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28 July 2018
The mannose-dependent epitope for neutralizing antibody 2G12 on human immunodeficiency virus type 1 glycoprotein gp120.
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28 July 2018
3D domain swapping: as domains continue to swap
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28 July 2018
Three-dimensional domain swapping in p13suc1 occurs in the unfolded state and is controlled by conserved proline residues.
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28 July 2018
Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies
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28 July 2018
Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate
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28 July 2018
Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1
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28 July 2018
Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody
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28 July 2018
Coordination of immunoglobulin chain folding and immunoglobulin chain assembly is essential for the formation of functional IgG.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950590
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28 July 2018
Generation of Human Monoclonal Antibodies against HIV-1 Proteins; Electrofusion and Epstein-Barr Virus Transformation for Peripheral Blood Lymphocyte Immortalization
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28 July 2018
High-level expression of a recombinant antibody from myeloma cells using a glutamine synthetase gene as an amplifiable selectable marker
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950590
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28 July 2018
Kinetic analysis provides insight into the mechanism of ribonuclease A oligomer formation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950590
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28 October 2018
Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950590
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28 October 2018
Protein acrobatics in pairs--dimerization via domain swapping
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950590
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28 October 2018
Design and expression of a dimeric form of human immunodeficiency virus type 1 antibody 2G12 with increased neutralization potency
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950590
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28 October 2018
An HIV vaccine--evolving concepts
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950590
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28 October 2018
Progress and obstacles in the development of an AIDS vaccine
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28 October 2018
HIV vaccine design and the neutralizing antibody problem
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950590
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28 October 2018
Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120
1 reference
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950590
retrieved
28 October 2018
Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG.
1 reference
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950590
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28 October 2018
Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950590
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28 October 2018
Molecular Characterization of Five Neutralizing Anti-HIV Type 1 Antibodies: Identification of Nonconventional D Segments in the Human Monoclonal Antibodies 2G12 and 2F5
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20702640
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Antigen drives very low affinity B cells to become plasmacytes and enter germinal centers
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20702640
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
HIV vaccines
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20702640
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Immunology and the elusive AIDS vaccine
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20702640
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1128/JVI.01111-10
1 reference
stated in
Europe PubMed Central
PMC publication ID
2950590
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702640%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
PMC publication ID
2950590
1 reference
stated in
Europe PubMed Central
PMC publication ID
2950590
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702640%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
PubMed publication ID
20702640
1 reference
stated in
Europe PubMed Central
PMC publication ID
2950590
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702640%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
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