(Q34178846)

31 July 2017

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title

Anti-angiogenic treatment strategies for malignant brain tumors (English)

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31 July 2017

angiogenesis inhibitor

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Kirsch M

1

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31 July 2017

Schackert G

series ordinal

2

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31 July 2017

Black PM

series ordinal

3

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31 July 2017

1 October 2000

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Journal of Neuro-Oncology

31 July 2017

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31 July 2017

50

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31 July 2017

1-2

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31 July 2017

149-163

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https://scigraph.springernature.com/pub.10.1023/a:1006487412567

31 July 2017

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cites work

Porphyrin analogues as novel antagonists of fibroblast growth factor and vascular endothelial growth factor receptor binding that inhibit endothelial cell proliferation, tumor progression, and metastasis

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12 December 2020

Small molecule inhibitors of tumor-promoted angiogenesis, including protein tyrosine kinase inhibitors

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12 December 2020

Angiostatin induces and sustains dormancy of human primary tumors in mice

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12 December 2020

Requirement of vascular integrin alpha v beta 3 for angiogenesis

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12 December 2020

The tumor-suppressing activity of angiostatin protein resides within kringles 1 to 3

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12 December 2020

Overexpression of thrombospondin-1 decreases angiogenesis and inhibits the growth of human cutaneous squamous cell carcinomas

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12 December 2020

Thrombospondin-2: a potent endogenous inhibitor of tumor growth and angiogenesis

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12 December 2020

Expression of vascular endothelial growth factor induces an invasive phenotype in human squamous cell carcinomas

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12 December 2020

Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2

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12 December 2020

Endostatin induces endothelial cell apoptosis

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12 December 2020

Metalloproteases and urokinase in angiogenesis and tumor progression.

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12 December 2020

Vascular permeability factor in brain metastases: correlation with vasogenic brain edema and tumor angiogenesis

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12 December 2020

Inhibition of tumor growth and metastasis by targeting tumor-associated angiogenesis with antagonists to the receptors of vascular endothelial growth factor

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12 December 2020

Alpha v integrins as receptors for tumor targeting by circulating ligands.

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12 December 2020

Generation of an angiostatin-like fragment from plasminogen by stromelysin-1 (MMP-3)

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12 December 2020

Suramin binds to platelet-derived growth factor and inhibits its biological activity

1 reference

12 December 2020

Suramin is a Potent Inhibitor of Vascular Endothelial Growth Factor. A Contribution to the Molecular Basis of its Antiangiogenic Action

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12 December 2020

Matrix metalloproteinase-2 activation modulates glioma cell migration.

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12 December 2020

Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis

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12 December 2020

Clinical applications of angiogenic growth factors and their inhibitors

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12 December 2020

Expression of integrin alpha v beta 3 in small blood vessels of glioblastoma tumors.

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12 December 2020

Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in patients with ductal carcinoma in situ of the breast

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12 December 2020

Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

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12 December 2020

Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis

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12 December 2020

Isolation of the thrombospondin membrane receptor

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12 December 2020

Therapy with thalidomide in refractory multiple myeloma patients - the revival of an old drug

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12 December 2020

Antitumor effect of TNP-470 on glial tumors transplanted in rats.

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12 December 2020

Suramin inhibits C6 glioma-induced angiogenesis in vitro.

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12 December 2020

Efficacy and concentration-response of murine anti-VEGF monoclonal antibody in tumor-bearing mice and extrapolation to humans

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12 December 2020

Suramin treatment of human glioma xenografts; effects on tumor vasculature and oxygenation status

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12 December 2020

Anti-angiogenic cues from vascular basement membrane collagen

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12 December 2020

Thalidomide may impede cell migration in primates by down-regulating integrin beta-chains: potential therapeutic utility in solid malignancies, proliferative retinopathy, inflammatory disorders, neointimal hyperplasia, and osteoporosis

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12 December 2020

Activation of mitogen-activated protein kinases by vascular endothelial growth factor and basic fibroblast growth factor in capillary endothelial cells is inhibited by the antiangiogenic factor 16-kDa N-terminal fragment of prolactin

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12 December 2020

Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1

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12 December 2020

Successful treatment of multiple myeloma relapsing after high-dose therapy and autologous transplantation with thalidomide as a single agent

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12 December 2020

Cloning, expression, and in vitro activity of human endostatin

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12 December 2020

Inhibition of angiogenesis and growth of human non-malignant and malignant meningiomas by TNP-470.

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12 December 2020

Synergy between angiostatin and endostatin: inhibition of ovarian cancer growth.

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12 December 2020

Anti-proliferative effects of TNP-470 on human malignant glioma in vivo: potent inhibition of tumor angiogenesis.

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12 December 2020

Targeting the tumor vasculature: inhibition of tumor growth by a vascular endothelial growth factor-toxin conjugate

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12 December 2020

Suppression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factor

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12 December 2020

Endostatin inhibits VEGF-induced endothelial cell migration and tumor growth independently of zinc binding

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12 December 2020

Potentiation of the antitumor effect of ionizing radiation by brief concomitant exposures to angiostatin.

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12 December 2020

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

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12 December 2020

Thalidomide is an inhibitor of angiogenesis

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12 December 2020

Frequent good partial remissions from thalidomide including best response ever in patients with advanced refractory and relapsed myeloma

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12 December 2020

Suppression of angiogenesis and tumor growth by the inhibitor K1-5 generated by plasmin-mediated proteolysis

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12 December 2020

Vascular endothelial growth factor expression and vascular density as prognostic markers of survival in patients with low-grade astrocytoma.

1 reference

12 December 2020

Durable clinical response of refractory hepatocellular carcinoma to orally administered thalidomide

1 reference

12 December 2020

In vitro inhibition of endothelial cell growth by the antiangiogenic drug AGM-1470 (TNP-470) and the anti-endoglin antibody TEC-11.

1 reference

12 December 2020

Angiostatin: A Circulating Endothelial Cell Inhibitor That Suppresses Angiogenesis and Tumor Growth

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12 December 2020

Cell-extracellular matrix interaction in glioma invasion

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12 December 2020

The angiogenesis inhibitor TNP-470 reduces the growth rate of human neuroblastoma in nude rats

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12 December 2020

Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance.

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12 December 2020

Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

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12 December 2020

Concomitant conjugal gliomas with similar histologic features.

1 reference

12 December 2020

Designing therapies that target tumor blood vessels

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12 December 2020

Kringle domains of human angiostatin. Characterization of the anti-proliferative activity on endothelial cells

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12 December 2020

Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth

1 reference

12 December 2020

Tumor angiogenesis: past, present and the near future

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12 December 2020

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

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12 December 2020

Meningiomas: role of vascular endothelial growth factor/vascular permeability factor in angiogenesis and peritumoral edema.

1 reference

12 December 2020

Tumor angiogenesis--new drugs on the block

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12 December 2020

Matrix metalloproteinases and metastatic cancer.

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12 December 2020

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1 reference

12 December 2020

The effect of thalidomide on experimental tumors and metastases

1 reference

12 December 2020

Basement membrane invasion of glioma cells mediated by integrin receptors.

1 reference

12 December 2020

Combined effects of angiostatin and ionizing radiation in antitumour therapy

1 reference

12 December 2020

Experimental and clinical studies on the use of matrix metalloproteinase inhibitors for the treatment of cancer

1 reference

12 December 2020

Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth

1 reference

12 December 2020

Angiostatin-converting enzyme activities of human matrilysin (MMP-7) and gelatinase B/type IV collagenase (MMP-9)

1 reference

12 December 2020

TNP-470 (AGM-1470): mechanisms of action and early clinical development.

1 reference

12 December 2020

A peptidomimetic antagonist of the integrin alpha(v)beta3 inhibits Leydig cell tumor growth and the development of hypercalcemia of malignancy

1 reference

12 December 2020

Quantitative measurement of soluble cytokeratin fragments in tissue cytosol of 599 node negative breast cancer patients: a prognostic marker possibly associated with apoptosis

1 reference

12 December 2020

Novel small molecule alpha v integrin antagonists: comparative anti-cancer efficacy with known angiogenesis inhibitors

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12 December 2020

Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3.

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12 December 2020

Tumor invasion, proteolysis, and angiogenesis

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12 December 2020

Mouse Col18a1 is expressed in a tissue-specific manner as three alternative variants and is localized in basement membrane zones

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12 December 2020

Antiangiogenic therapy of human esophageal cancers with thalidomide in nude mice

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12 December 2020

Long-term follow-up confirms prognostic impact of PAI-1 and cathepsin D and L in primary breast cancer

1 reference

12 December 2020

Angiostatin gene transfer: inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with a mitosis arrest

1 reference

12 December 2020

Functions of Tie1 and Tie2 receptor tyrosine kinases in vascular development

1 reference

12 December 2020

Endostatin: an endogenous inhibitor of angiogenesis and tumor growth

1 reference

12 December 2020

Mechanism of action in thalidomide teratogenesis

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12 December 2020

Hypoxia-inducible angiopoietin-2 expression is mimicked by iodonium compounds and occurs in the rat brain and skin in response to systemic hypoxia and tissue ischemia

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12 December 2020

Matrix metalloproteinases and metastasis

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12 December 2020

Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis.

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12 December 2020

Mouse endostatin inhibits the formation of lung and liver metastases

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12 December 2020

Models of in vitro angiogenesis: endothelial cell differentiation on fibrin but not matrigel is transcriptionally dependent

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12 December 2020

Continuous low dose Thalidomide: a phase II study in advanced melanoma, renal cell, ovarian and breast cancer

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12 December 2020

Inhibition of angiogenesis in human glioblastomas by chromosome 10 induction of thrombospondin-1.

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12 December 2020

A thrombin-sensitive protein of human platelet membranes

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12 December 2020

Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD.

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12 December 2020

Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity

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12 December 2020

Regulation of angiostatin production by matrix metalloproteinase-2 in a model of concomitant resistance

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12 December 2020

Correlation of vascular endothelial growth factor messenger RNA expression with peritumoral vasogenic cerebral edema in meningiomas

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12 December 2020

Combination oral antiangiogenic therapy with thalidomide and sulindac inhibits tumour growth in rabbits

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12 December 2020

Zinc-binding of endostatin is essential for its antiangiogenic activity

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12 December 2020

Inhibitory effect of TNP-470, a new anti-angiogenic agent, on the estrogen induced rat pituitary tumors

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12 December 2020

Matrix metalloproteinases generate angiostatin: effects on neovascularization

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12 December 2020

Up-regulation of vascular endothelial growth factor expression in a rat glioma is conferred by two distinct hypoxia-driven mechanisms.

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12 December 2020

Prognostic significance of angiogenesis in human pancreatic cancer

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12 December 2020

Neutralizing anti-vascular endothelial growth factor antibody completely inhibits angiogenesis and growth of human prostate carcinoma micro tumors in vivo

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12 December 2020

Zinc-dependent dimers observed in crystals of human endostatin

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12 December 2020

Vascular endothelial growth/permeability factor expression in human glioma specimens: correlation with vasogenic brain edema and tumor-associated cysts.

1 reference

12 December 2020

Transfection of thrombospondin 1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesis.

1 reference

12 December 2020

Antiproliferative and angiostatic activity of suramin analogues

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12 December 2020

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo.

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12 December 2020

Angiopoietin-1 protects the adult vasculature against plasma leakage.

1 reference

12 December 2020

Experimental studies of the antitumor effect of TNP-470 on malignant brain tumors. Antitumor effect of TNP-470 on a human medulloblastoma xenograft line

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12 December 2020

Vascular endothelial growth factor (VEGF) in astrocytic gliomas--a prognostic factor?

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12 December 2020

Growth factors in gliomas revisited

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12 December 2020

Lumen formation and other angiogenic activities of cultured capillary endothelial cells are inhibited by thrombospondin-1.

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12 December 2020

Effect of thalidomide and structurally related compounds on corneal angiogenesis is comparable to their teratological potency

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12 December 2020

Structure, function and tissue forms of the C-terminal globular domain of collagen XVIII containing the angiogenesis inhibitor endostatin

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12 December 2020

Retrovirus producer cells encoding antisense VEGF prolong survival of rats with intracranial GS9L gliomas

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12 December 2020

Inhibition of Angiogenesis by Recombinant Human Platelet Factor-4 and Related Peptides

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12 December 2020

Viral vector-targeted antiangiogenic gene therapy utilizing an angiostatin complementary DNA.

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12 December 2020

Effects of TNP-470, a potent angiogenesis inhibitor, on growth of hematopoietic progenitors

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12 December 2020

Antiangiogenic agents

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12 December 2020

Thalidomide and a thalidomide analogue inhibit endothelial cell proliferation in vitro

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12 December 2020

Vascular endothelial growth factor (VEGF) expression and survival in human epithelial ovarian carcinomas

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12 December 2020

Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis

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12 December 2020

Endothelial progenitor cells as putative targets for angiostatin

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12 December 2020

Growth Inhibition of Murine Melanoma and Human Colon Carcinoma by Recombinant Human Platelet Factor 4

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12 December 2020

Target molecules for anti-angiogenic therapy: from basic research to clinical trials

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12 December 2020

Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: novel concepts of angiostatic therapy from intravital videomicroscopy.

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12 December 2020

Vascular apoptosis and involution in gliomas precede neovascularization: a novel concept for glioma growth and angiogenesis.

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12 December 2020

KDR activation in astrocytic neoplasms

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12 December 2020

In situ expression of angiopoietins in astrocytomas identifies angiopoietin-2 as an early marker of tumor angiogenesis.

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12 December 2020

Tumor targeting with a selective gelatinase inhibitor

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12 December 2020

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo

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12 December 2020

Heterogeneous regional expression patterns of matrix metalloproteinases in human malignant gliomas.

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12 December 2020

Purification and characterization of recombinant murine endostatin in E. coli

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12 December 2020

Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1

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12 December 2020

Secretion of matrix metalloproteinase-2 (72 kD gelatinase/type IV collagenase = gelatinase A) by malignant human glioma cell lines: implications for the growth and cellular invasion of the extracellular matrix.

1 reference

12 December 2020

Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumors.

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12 December 2020

Downregulation of endothelial cell thrombospondin 1 enhances in vitro angiogenesis

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12 December 2020

Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model

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12 December 2020

Angiostatin binds ATP synthase on the surface of human endothelial cells

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12 December 2020

Hypothesis: thalidomide embryopathy-proposed mechanism of action

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12 December 2020

Phase II trial of the antiangiogenic agent thalidomide in patients with recurrent high-grade gliomas

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12 December 2020

Chemotherapy targeted to tumor vasculature.

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12 December 2020

Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin

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12 December 2020

Expression of matrix metalloproteinases in human glioma cell lines in the presence of IL-10.

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12 December 2020

Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer

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12 December 2020

Three distinct D-amino acid substitutions confer potent antiangiogenic activity on an inactive peptide derived from a thrombospondin-1 type 1 repeat

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12 December 2020

Antiangiogenic and antiproliferative activity of suramin analogues

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12 December 2020

Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity

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12 December 2020

Inhibitory effect of suramin in rat models of angiogenesis in vitro and in vivo

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12 December 2020

Expression of vascular endothelial growth factor in patients with testicular germ cell tumors as an indicator of metastatic disease

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12 December 2020

Up-regulation of flk-1/vascular endothelial growth factor receptor 2 by its ligand in a cerebral slice culture system.

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12 December 2020

Clinical significance of urokinase-type plasminogen activator activity in hepatocellular carcinoma

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12 December 2020

MMP inhibitors: experimental and clinical studies

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12 December 2020

Inhibition of proliferation of human cerebral meningioma cells by suramin: effects on cell growth, cell cycle phases, extracellular growth factors, and PDGF-BB autocrine growth loop

1 reference

12 December 2020

New functions for non-collagenous domains of human collagen type IV. Novel integrin ligands inhibiting angiogenesis and tumor growth in vivo.

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12 December 2020

Identifiers

DOI

10.1023/A:1006487412567

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Dimensions Publication ID

31 July 2017

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