(Q34180670)

31 July 2017

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title

Signalling to and from tight junctions (English)

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Gene Ontology release 2020-05-02

31 July 2017

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Maria S Balda

2

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Karl Matter

object named as

Karl Matter

series ordinal

1

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publication date

1 March 2003

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Nature Reviews Molecular Cell Biology

31 July 2017

published in

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31 July 2017

volume

4

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31 July 2017

issue

3

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31 July 2017

page(s)

225-236

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https://scigraph.springernature.com/pub.10.1038/nrm1055

31 July 2017

exact match

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cites work

Junctional complexes in various epithelia

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Molecular physiology and pathophysiology of tight junctions. I. Biogenesis of tight junctions and epithelial polarity

31 March 2020

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Transmembrane proteins of tight junctions.

31 March 2020

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Multifunctional strands in tight junctions

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Molecular complexity of vertebrate tight junctions (Review).

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Epithelial cell polarity and cell junctions in Drosophila

31 March 2020

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Dissociation of Madin-Darby canine kidney epithelial cells by the monoclonal antibody anti-arc-1: mechanistic aspects and identification of the antigen as a component related to uvomorulin

31 March 2020

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Tight junction formation in cultured epithelial cells (MDCK).

31 March 2020

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A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptide

31 March 2020

1 reference

Assembly and sealing of tight junctions: possible participation of G-proteins, phospholipase C, protein kinase C and calmodulin

31 March 2020

1 reference

Ca2+-dependent and Ca2+-independent regulation of the thyroid epithelial junction complex by protein kinases

31 March 2020

1 reference

Identification of isoforms of G proteins and PKC that colocalize with tight junctions

31 March 2020

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Involvement of a heterotrimeric G protein alpha subunit in tight junction biogenesis

31 March 2020

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Zonula occludens-1 is a scaffolding protein for signaling molecules. Galpha(12) directly binds to the Src homology 3 domain and regulates paracellular permeability in epithelial cells

31 March 2020

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The extended protein kinase C superfamily

31 March 2020

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The role of phosphorylation in development of tight junctions in cultured renal epithelial (MDCK) cells

31 March 2020

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Assembly of the tight junction: the role of diacylglycerol

31 March 2020

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An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3

31 March 2020

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PARsing embryonic polarity

31 March 2020

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Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity.

31 March 2020

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Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions

31 March 2020

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The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)

31 March 2020

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A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity

31 March 2020

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The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

31 March 2020

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Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures

31 March 2020

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Cdc42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cells

31 March 2020

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aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization

31 March 2020

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Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex

31 March 2020

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Rho-family GTPases in cadherin-mediated cell-cell adhesion

31 March 2020

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Trans-interactions of nectins induce formation of filopodia and Lamellipodia through the respective activation of Cdc42 and Rac small G proteins

31 March 2020

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Tight junction, a platform for trafficking and signaling protein complexes

31 March 2020

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New perspectives on mechanisms involved in generating epithelial cell polarity

31 March 2020

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The small GTPase Rab13 regulates assembly of functional tight junctions in epithelial cells

31 March 2020

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Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia

31 March 2020

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Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells

31 March 2020

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Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells

31 March 2020

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Opposite regulation of transepithelial electrical resistance and paracellular permeability by Rho in Madin-Darby canine kidney cells

31 March 2020

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Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPases

31 March 2020

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Regulation of cadherin function by Rho and Rac: modulation by junction maturation and cellular context.

31 March 2020

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Regulation of tight junction permeability and occludin phosphorylation by Rhoa-p160ROCK-dependent and -independent mechanisms

31 March 2020

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Rho GTPases in cell biology

31 March 2020

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Expression of the catalytic domain of myosin light chain kinase increases paracellular permeability

31 March 2020

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Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation

31 March 2020

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Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II.

31 March 2020

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Identification of a tight junction-associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeability

31 March 2020

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crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia

31 March 2020

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Mutations in a human homologue of Drosophila crumbs cause retinitis pigmentosa (RP12)

31 March 2020

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Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres

31 March 2020

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Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis

31 March 2020

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Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila.

31 March 2020

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Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity

31 March 2020

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Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts.

31 March 2020

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The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost

31 March 2020

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hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells

31 March 2020

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Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1)

31 March 2020

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The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions

31 March 2020

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Direct interaction of two polarity complexes implicated in epithelial tight junction assembly

31 March 2020

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Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly

31 March 2020

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Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion

31 March 2020

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How do small GTPase signal transduction pathways regulate cell cycle entry?

31 March 2020

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Absence of the tight junctional protein AF-6 disrupts epithelial cell-cell junctions and cell polarity during mouse development.

31 March 2020

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Constitutively active mutant of the mitogen-activated protein kinase kinase MEK1 induces epithelial dedifferentiation and growth inhibition in madin-darby canine kidney-C7 cells

31 March 2020

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Oncogenic Raf-1 disrupts epithelial tight junctions via downregulation of occludin

31 March 2020

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Basal extracellular signal-regulated kinase activity modulates cell-cell and cell-matrix interactions

31 March 2020

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Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells

31 March 2020

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Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily

31 March 2020

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The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin

31 March 2020

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The Ras target AF-6 interacts with ZO-1 and serves as a peripheral component of tight junctions in epithelial cells

31 March 2020

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Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction

31 March 2020

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Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein

31 March 2020

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Afadin: A key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesis

31 March 2020

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The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions

31 March 2020

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Submembranous junctional plaque proteins include potential tumor suppressor molecules

31 March 2020

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The Drosophila tamou gene, a component of the activating pathway of extramacrochaetae expression, encodes a protein homologous to mammalian cell-cell junction-associated protein ZO-1.

31 March 2020

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Polychaetoid is required to restrict segregation of sensory organ precursors from proneural clusters in Drosophila.

31 March 2020

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Direct binding between two PDZ domain proteins Canoe and ZO-1 and their roles in regulation of the jun N-terminal kinase pathway in Drosophila morphogenesis.

31 March 2020

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The PDZ domains of zonula occludens-1 induce an epithelial to mesenchymal transition of Madin-Darby canine kidney I cells. Evidence for a role of beta-catenin/Tcf/Lef signaling

31 March 2020

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Truncation mutants of the tight junction protein ZO-1 disrupt corneal epithelial cell morphology

31 March 2020

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Perturbation of the tight junction permeability barrier by occludin loop peptides activates beta-catenin/TCF/LEF-mediated transcription

31 March 2020

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Loss of the tight junction MAGUK ZO-1 in breast cancer: relationship to glandular differentiation and loss of heterozygosity

31 March 2020

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Tight junction protein ZO-2 is differentially expressed in normal pancreatic ducts compared to human pancreatic adenocarcinoma

31 March 2020

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Altered Expression and Localization of the Tight Junction Protein ZO-1 in Primary and Metastatic Pancreatic Cancer

31 March 2020

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Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas

31 March 2020

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Adhesion signaling: how beta-catenin interacts with its partners

31 March 2020

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New aspects of Wnt signaling pathways in higher vertebrates

31 March 2020

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Link of the unique oncogenic properties of adenovirus type 9 E4-ORF1 to a select interaction with the candidate tumor suppressor protein ZO-2

31 March 2020

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Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins

31 March 2020

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Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteins

31 March 2020

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The tight junction protein ZO-2 localizes to the nucleus and interacts with the heterogeneous nuclear ribonucleoprotein scaffold attachment factor-B

31 March 2020

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Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2

31 March 2020

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Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase

31 March 2020

1 reference

The junction-associated protein, zonula occludens-1, localizes to the nucleus before the maturation and during the remodeling of cell-cell contacts.

31 March 2020

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Nuclear localization of the tight junction protein ZO-2 in epithelial cells

31 March 2020

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The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression

31 March 2020

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Symplekin, a novel type of tight junction plaque protein

31 March 2020

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Complex protein interactions within the human polyadenylation machinery identify a novel component

31 March 2020

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Symplekin, a constitutive protein of karyo- and cytoplasmic particles involved in mRNA biogenesis in Xenopus laevis oocytes

31 March 2020

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huASH1 protein, a putative transcription factor encoded by a human homologue of the Drosophila ash1 gene, localizes to both nuclei and cell-cell tight junctions

31 March 2020

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The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density

31 March 2020

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Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1.

31 March 2020

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Polarized monolayers formed by epithelial cells on a permeable and translucent support

31 March 2020

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Transepithelial migration of human neutrophils: an in vitro model system

31 March 2020

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Catenins and zonula occludens-1 form a complex during early stages in the assembly of tight junctions

31 March 2020

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Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to alpha catenin and actin filaments

31 March 2020

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The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein

31 March 2020

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Direct association of the gap junction protein connexin-43 with ZO-1 in cardiac myocytes

31 March 2020

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alpha-catenin-independent recruitment of ZO-1 to nectin-based cell-cell adhesion sites through afadin

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1055

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Dimensions Publication ID

31 July 2017

1047825048

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