(Q34182046)

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The aggregation and neurotoxicity of TDP-43 and its ALS-associated 25 kDa fragment are differentially affected by molecular chaperones in Drosophila

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scholarly article

1 reference

Europe PubMed Central

31 July 2017

The aggregation and neurotoxicity of TDP-43 and its ALS-associated 25 kDa fragment are differentially affected by molecular chaperones in Drosophila (English)

1 reference

Europe PubMed Central

31 July 2017

0 references

molecular chaperones

0 references

1 reference

based on heuristic

inferred from title

amyotrophic lateral sclerosis

1 reference

based on heuristic

inferred from title

toxic encephalopathy

1 reference

based on heuristic

inferred from title

4

object named as

Christopher M Dobson

1 reference

Europe PubMed Central

31 July 2017

author name string

Jenna M Gregory

1

1 reference

Europe PubMed Central

31 July 2017

Teresa P Barros

2

1 reference

Europe PubMed Central

31 July 2017

Sarah Meehan

3

1 reference

Europe PubMed Central

31 July 2017

Leila M Luheshi

5

1 reference

Europe PubMed Central

31 July 2017

language of work or name

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publication date

22 February 2012

1 reference

Europe PubMed Central

31 July 2017

1 reference

Europe PubMed Central

31 July 2017

7

1 reference

Europe PubMed Central

31 July 2017

2

1 reference

Europe PubMed Central

31 July 2017

e31899

1 reference

Europe PubMed Central

31 July 2017

copyright license

Creative Commons Attribution 4.0 International

22 February 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3284513

28 July 2018

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

1 reference

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TDP-43-mediated neuron loss in vivo requires RNA-binding activity

1 reference

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28 July 2018

Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice

1 reference

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28 July 2018

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS).

1 reference

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Chaperone networks: tipping the balance in protein folding diseases

1 reference

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The interaction of alphaB-crystallin with mature alpha-synuclein amyloid fibrils inhibits their elongation

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A Drosophila model for TDP-43 proteinopathy

1 reference

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TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration

1 reference

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Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease

1 reference

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17-AAG induces cytoplasmic alpha-synuclein aggregate clearance by induction of autophagy

1 reference

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TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

1 reference

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28 July 2018

TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity

1 reference

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28 July 2018

Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies

1 reference

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28 July 2018

Structural determinants of the cellular localization and shuttling of TDP-43.

1 reference

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28 July 2018

A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity

1 reference

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Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes

1 reference

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28 July 2018

Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation

1 reference

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Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3284513

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Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3284513

28 July 2018

Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43.

1 reference

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An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases

1 reference

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28 July 2018

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3284513

28 July 2018

Drosophila in the study of neurodegenerative disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3284513

28 July 2018

Protein misfolding, functional amyloid, and human disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3284513

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17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

1 reference

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Intraneuronal Abeta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease.

1 reference

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Principles of protein folding, misfolding and aggregation

1 reference

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Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9

1 reference

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A Drosophila model of Parkinson's disease

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1 reference

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28 July 2018

Adapting proteostasis for disease intervention

1 reference

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21 January 2018

Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy

1 reference

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21 January 2018

Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior

1 reference

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Heat shock transcription factor 1-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones

1 reference

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Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila.

1 reference

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21 January 2018

Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila.

1 reference

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21 January 2018

Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons.

1 reference

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Identification of the Drosophila ortholog of HSPB8: implication of HSPB8 loss of function in protein folding diseases.

1 reference

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Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis.

1 reference

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28 October 2018

Identifiers

10.1371/JOURNAL.PONE.0031899

1 reference

Europe PubMed Central

31 July 2017

2012PLoSO...731899G

0 references

1 reference

Europe PubMed Central

31 July 2017

1 reference

Europe PubMed Central

31 July 2017

ResearchGate publication ID

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