(Q34183761)

31 July 2017

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title

Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks (English)

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31 July 2017

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P D Adams

1

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31 July 2017

language of work or name

English

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publication date

1 March 2001

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Biochimica et Biophysica Acta

31 July 2017

published in

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31 July 2017

volume

1471

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31 July 2017

issue

3

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31 July 2017

page(s)

M123-33

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The retinoblastoma protein and cell cycle control

31 July 2017

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Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product

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The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus

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Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7

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7 January 2021

The cell cycle and development: redundant roles of cell cycle regulators

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7 January 2021

The retinoblastoma gene family in differentiation and development.

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7 January 2021

RB kinases and RB-binding proteins: new points of view

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7 January 2021

The regulation of E2F by pRB-family proteins

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7 January 2021

The Rb/E2F pathway: expanding roles and emerging paradigms

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7 January 2021

Histone acetylases and deacetylases in cell proliferation

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7 January 2021

Retinoblastoma protein recruits histone deacetylase to repress transcription

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7 January 2021

Retinoblastoma protein represses transcription by recruiting a histone deacetylase

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7 January 2021

Rb interacts with histone deacetylase to repress transcription

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7 January 2021

DNA tumor virus transforming proteins and the cell cycle

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7 January 2021

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product

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7 January 2021

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein

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7 January 2021

Identification of distinct roles for separate E1A domains in disruption of E2F complexes

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7 January 2021

Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes

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7 January 2021

Abrogation of retinoblastoma protein function by c-Abl through tyrosine kinase-dependent and -independent mechanisms

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7 January 2021

Disruption of retinoblastoma protein function by coexpression of its C pocket fragment.

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7 January 2021

A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

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7 January 2021

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

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7 January 2021

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

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7 January 2021

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

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7 January 2021

Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product

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7 January 2021

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

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7 January 2021

Physical interaction of the retinoblastoma protein with human D cyclins

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7 January 2021

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

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7 January 2021

Interaction between the retinoblastoma protein and the oncoprotein MDM2

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7 January 2021

Cyclin E-induced S phase without activation of the pRb/E2F pathway.

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https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation

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https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

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https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age

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7 January 2021

Principles of CDK regulation

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7 January 2021

Evolving ideas about cyclins

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7 January 2021

Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein

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https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases

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https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation

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7 January 2021

Defining the substrate specificity of cdk4 kinase-cyclin D1 complex

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7 January 2021

Defining the minimal portion of the retinoblastoma protein that serves as an efficient substrate for cdk4 kinase/cyclin D1 complex

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7 January 2021

The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases

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7 January 2021

A- and B-type cyclins differentially modulate substrate specificity of cyclin-cdk complexes

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7 January 2021

Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F.

1 reference

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7 January 2021

Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase

1 reference

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7 January 2021

Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A.

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7 January 2021

Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization

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7 January 2021

Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Specific regulation of E2F family members by cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Cells arrested in G1 by the v-Abl tyrosine kinase do not express cyclin A despite the hyperphosphorylation of RB.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Cumulative effect of phosphorylation of pRB on regulation of E2F activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

The Rb family contains a conserved cyclin-dependent-kinase-regulated transcriptional repressor motif

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Domains A and B in the Rb pocket interact to form a transcriptional repressor motif

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Rescue of Cyclin D1 Deficiency by Knockin Cyclin E

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https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Requirements for cell cycle arrest by p16INK4a

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity.

1 reference

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7 January 2021

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

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7 January 2021

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

1 reference

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7 January 2021

Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF

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7 January 2021

The HIP1 binding site is required for growth regulation of the dihydrofolate reductase gene promoter

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https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

E2F mediates dihydrofolate reductase promoter activation and multiprotein complex formation in human cytomegalovirus infection

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https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

The mammalian SWI/SNF complex and the control of cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

BRG-1 is required for RB-mediated cell cycle arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Functional interactions between the hBRM/hBRG1 transcriptional activators and the pRB family of proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

RB and hbrm cooperate to repress the activation functions of E2F1

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Mitotic inactivation of a human SWI/SNF chromatin remodeling complex

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Role of the retinoblastoma protein in the pathogenesis of human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

pRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Establishment of irreversible growth arrest in myogenic differentiation requires the RB LXCXE-binding function

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https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family

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https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Regulation of differentiation by HBP1, a target of the retinoblastoma protein

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7 January 2021

Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle

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https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

A novel Rb- and p300-binding protein inhibits transactivation by MyoD

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https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900019-1

7 January 2021

10.1016/S0304-419X(01)00019-1

Identifiers

DOI

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31 July 2017

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