(Q34188550)

31 July 2017

title

Farnesyltransferase--new insights into the zinc-coordination sphere paradigm: evidence for a carboxylate-shift mechanism (English)

1 reference

Pedro Alexandrino Fernandes

31 July 2017

Sérgio F Sousa

1

0 references

object named as

Pedro A Fernandes

series ordinal

2

0 references

Maria J. Ramos

object named as

Maria João Ramos

series ordinal

3

0 references

language of work or name

English

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publication date

22 October 2004

1 reference

31 July 2017

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31 July 2017

volume

88

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31 July 2017

issue

1

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31 July 2017

page(s)

483-494

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In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus.

31 July 2017

cites work

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5 July 2018

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Catalytic mechanism of matrix metalloproteinases: two-layered ONIOM study

5 July 2018

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Reaction path of protein farnesyltransferase at atomic resolution

5 July 2018

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Protein farnesyltransferase and protein prenylation in Plasmodium falciparum

5 July 2018

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Inhibitors of protein farnesyltransferase as novel anticancer agents

5 July 2018

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Farnesyl transferase inhibitors: a novel targeted tnerapy for cancer

5 July 2018

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The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics

5 July 2018

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Geometry of metal-ligand interactions in proteins

5 July 2018

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Small GTP-binding proteins

5 July 2018

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Function and mechanism of zinc metalloenzymes.

5 July 2018

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The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures

5 July 2018

1 reference

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Carboxylate binding modes in zinc proteins: a theoretical study

5 July 2018

1 reference

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Analysis of zinc binding sites in protein crystal structures

5 July 2018

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Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density

5 July 2018

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Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue

5 July 2018

1 reference

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5 July 2018

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Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate

5 July 2018

1 reference

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Protein farnesyltransferase: structure and implications for substrate binding

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1305025

Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1305025

Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells

5 July 2018

1 reference

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A mechanism for posttranslational modifications of proteins by yeast protein farnesyltransferase

5 July 2018

1 reference

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All ras proteins are polyisoprenylated but only some are palmitoylated

5 July 2018

1 reference

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Interaction of metal ions with carboxylic and carboxamide groups in protein structures

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1305025

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1305025

Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1305025

Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1305025

Active-site zinc ligands and activated H2O of zinc enzymes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1305025

Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1305025

Sequence dependence of protein isoprenylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1305025

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1305025

Divalent cation and prenyl pyrophosphate specificities of the protein farnesyltransferase from rat brain, a zinc metalloenzyme.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1305025

Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1305025

Farnesyltransferase inhibitors inhibit the growth of malaria parasites in vitro and in vivo

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1305025

Theoretical insights into the mechanism for thiol/disulfide exchange

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1305025

Theoretical study of ribonucleotide reductase mechanism-based inhibition by 2'-azido-2'-deoxyribonucleoside 5'-diphosphates

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1305025

Mutagenesis Studies of Protein Farnesyltransferase Implicate Aspartate β352 as a Magnesium Ligand

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1305025

Structural characterization of the zinc site in protein farnesyltransferase

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1305025

Kinetic studies of protein farnesyltransferase mutants establish active substrate conformation

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1305025

Theoretical studies on the mechanism of inhibition of Ribonucleotide Reductase by (E)-2'-Fluoromethylene-2'-deoxycitidine-5'-diphosphate

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1305025

Energies, structures, and electronic properties of molecules in solution with the C-PCM solvation model.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1305025

Theoretical Studies on the Mode of Inhibition of Ribonucleotide Reductase by 2′-Substituted Substrate Analogues

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1305025

Kinetic analysis of zinc ligand mutants of mammalian protein farnesyltransferase

28 October 2018

1 reference

12 December 2020

Effects of the protein environment on the structure and energetics of active sites of metalloenzymes. ONIOM study of methane monooxygenase and ribonucleotide reductase

1 reference

12 December 2020

H-Ras peptide and protein substrates bind protein farnesyltransferase as an ionized thiolate

1 reference

12 December 2020

Substitution of cadmium for zinc in farnesyl:protein transferase alters its substrate specificity

1 reference

12 December 2020

Evidence for a catalytic role of zinc in protein farnesyltransferase. Spectroscopy of Co2+-farnesyltransferase indicates metal coordination of the substrate thiolate

1 reference

12 December 2020

Mutational analysis of conserved residues of the beta-subunit of human farnesyl:protein transferase

1 reference

12 December 2020

Substrate binding is required for release of product from mammalian protein farnesyltransferase

1 reference

12 December 2020

Yeast protein farnesyltransferase. Site-directed mutagenesis of conserved residues in the beta-subunit

1 reference

12 December 2020

Recent Advances in Zinc Enzymology

1 reference

12 December 2020

10.1529/BIOPHYSJ.104.048207

Identifiers

DOI

1 reference

31 July 2017

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31 July 2017

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