(Q34207727)

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Comparison of the post-embolization effects of tissue-plasminogen activator and simvastatin on neurological outcome in a clinically relevant rat model of acute ischemic stroke

scientific article published on July 29, 2010

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Europe PubMed Central

PubMed publication ID

31 July 2017

Comparison of the post-embolization effects of tissue-plasminogen activator and simvastatin on neurological outcome in a clinically relevant rat model of acute ischemic stroke (English)

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31 July 2017

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Paul A. Lapchak

2

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Paul A. Lapchak

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14 June 2024

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Kama Z. Guluma

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29 July 2010

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14 June 2024

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14 June 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20673757/pdf/?tool=EBI

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14 June 2024

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20673757

14 June 2024

https://europepmc.org/articles/PMC2956588?pdf=render

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20673757

14 June 2024

https://doi.org/10.1016/j.brainres.2010.07.050

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14 June 2024

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10.1016/J.BRAINRES.2010.07.050

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14 June 2024

1 reference

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PubMed publication ID

31 July 2017

1354

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

206-216

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: synergism with a ROCK inhibitor but not the thrombolytic tissue plasminogen activator

1 reference

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1 reference

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5 July 2018

Statin therapy after first stroke reduces 10-year stroke recurrence and improves survival.

1 reference

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5 July 2018

Lipid-lowering drugs in ischemic stroke prevention and their influence on acute stroke outcome

1 reference

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5 July 2018

Inhibition of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase reduces leukocyte recruitment and hepatocyte apoptosis in endotoxin-induced liver injury

1 reference

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5 July 2018

Simvastatin attenuation of cerebral vasospasm after subarachnoid hemorrhage in rats via increased phosphorylation of Akt and endothelial nitric oxide synthase

1 reference

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5 July 2018

Treatment of embolic stroke in rats with bortezomib and recombinant human tissue plasminogen activator

1 reference

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5 July 2018

Effect of simvastatin, an established lipid-lowering drug, on pulmonary Chlamydia pneumoniae infection in mice

1 reference

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5 July 2018

Long-term protective effect of atorvastatin in permanent focal cerebral ischemia

1 reference

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5 July 2018

Neuroprotective effect of simvastatin in stroke: a comparison between adult and neonatal rat models of cerebral ischemia.

1 reference

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5 July 2018

Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia

1 reference

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5 July 2018

Differences in clot preparation determine outcome of recombinant tissue plasminogen activator treatment in experimental thromboembolic stroke

1 reference

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5 July 2018

Hemorrhagic transformation after fibrinolysis with tissue plasminogen activator: evaluation of role of hypertension with rat thromboembolic stroke model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956588

5 July 2018

Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice

1 reference

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5 July 2018

Effects of fluid management on edema volume and midline shift in a rat model of ischemic stroke

1 reference

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5 July 2018

Neurological impairment in rats after transient middle cerebral artery occlusion: a comparative study under various treatment paradigms

1 reference

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5 July 2018

Spontaneous reperfusion after ischemic stroke is associated with improved outcome

1 reference

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5 July 2018

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors increase fibrinolytic activity in rat aortic endothelial cells. Role of geranylgeranylation and Rho proteins

1 reference

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5 July 2018

Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase

1 reference

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5 July 2018

Early spontaneous improvement and deterioration of ischemic stroke patients. A serial study with transcranial Doppler ultrasonography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956588

5 July 2018

Natural history of the spontaneous reperfusion of human cerebral infarcts as assessed by 99mTc HMPAO SPECT.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956588

5 July 2018

A rat model of focal embolic cerebral ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956588

5 July 2018

A new rat model of thrombotic focal cerebral ischemia

1 reference

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5 July 2018

Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956588

5 July 2018

Spontaneous middle cerebral artery reperfusion in ischemic stroke. A follow-up study with transcranial Doppler

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956588

5 July 2018

Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956588

5 July 2018

Quantitative assessment of early brain damage in a rat model of focal cerebral ischaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956588

5 July 2018

Stroke, hemodilution, and mortality

1 reference

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5 July 2018

Reversible middle cerebral artery occlusion without craniectomy in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956588

5 July 2018

Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956588

5 July 2018

Morphometric evaluation of brain infarcts in rats and gerbils

1 reference

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5 July 2018

Triphenyltetrazolium chloride (TTC) as a marker for ischaemic changes in rat brain following permanent middle cerebral artery occlusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956588

5 July 2018

Middle cerebral artery occlusion in rats: a neurological and pathological evaluation of a reproducible model

1 reference

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The quest for the "Holy Grail" of ischemic stroke cytoprotection: Statins may not be the answer

1 reference

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1 reference

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28 October 2018

Early atorvastatin reduces hemorrhage after acute cerebral ischemia in diabetic rats

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Simvastatin enhances VEGF production and ameliorates impaired wound healing in experimental diabetes

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28 October 2018

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1 reference

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Simvastatin in the acute phase of ischemic stroke: a safety and efficacy pilot trial

1 reference

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28 October 2018

Postischemic administration of HMG CoA reductase inhibitor inhibits infarct expansion after transient middle cerebral artery occlusion

1 reference

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The impact of recanalization on ischemic stroke outcome: a meta-analysis

1 reference

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Cerebral embolic ischemia in rats: correlation of stroke severity and functional deficit as important outcome parameter

1 reference

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28 October 2018

Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Counci

1 reference

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28 October 2018

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28 October 2018

Simvastatin reduced ischemic brain injury and perfusion deficits in an embolic model of stroke

1 reference

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HMG-CoA reductase inhibitor simvastatin profoundly improves survival in a murine model of sepsis

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28 October 2018

Prophylactic but not delayed administration of simvastatin protects against long-lasting cognitive and morphological consequences of neonatal hypoxic-ischemic brain injury, reduces interleukin-1beta and tumor necrosis factor-alpha mRNA induction, an

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28 October 2018

Simvastatin reduces infarct size in a model of acute myocardial ischemia and reperfusion in the rat.

1 reference

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28 October 2018

Treatment with statins after induction of focal ischemia in rats reduces the extent of brain damage

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Arterial reocclusion in stroke patients treated with intravenous tissue plasminogen activator

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28 October 2018

Haemodilution for acute ischaemic stroke.

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High-dose atorvastatin after stroke or transient ischemic attack

1 reference

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Multicenter trial of hemodilution in acute ischemic stroke. I. Results in the total patient population. Scandinavian Stroke Study Group

1 reference

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12 December 2020

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Correlation of triphenyltetrazolium chloride perfusion staining with conventional neurohistology in the detection of early brain ischaemia

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12 December 2020

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1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Statins and stroke

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new animal model of cerebral infarction: magnetic embolization with carbonyl iron particles

1

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Simvastatin decreases nitric oxide overproduction and reverts the impaired vascular responsiveness induced by endotoxic shock in rats

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Intracisternal basic fibroblast growth factor enhances functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction

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Transient ischemic attacks with and without a relevant infarct on computed tomographic scans cannot be distinguished clinically. Dutch Transient Ischemic Attack Study Group

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10.1016/J.BRAINRES.2010.07.050

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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