(Q34218060)

31 July 2017

title

Crystal structure of the γ-secretase component nicastrin (English)

1 reference

31 July 2017

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9

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author name string

Tian Xie

1

1 reference

31 July 2017

Chuangye Yan

2

1 reference

31 July 2017

Rui Zhou

3

1 reference

31 July 2017

Yanyu Zhao

4

1 reference

31 July 2017

Linfeng Sun

5

1 reference

31 July 2017

Guanghui Yang

6

1 reference

31 July 2017

Peilong Lu

7

1 reference

31 July 2017

Dan Ma

8

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31 July 2017

language of work or name

English

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publication date

2 September 2014

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Proceedings of the National Academy of Sciences of the United States of America

31 July 2017

published in

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31 July 2017

volume

111

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31 July 2017

issue

37

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31 July 2017

page(s)

13349-13354

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Three-dimensional structure of human γ-secretase

31 July 2017

cites work

1 reference

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Dictyostelium possesses highly diverged presenilin/gamma-secretase that regulates growth and cell-fate specification and can accurately process human APP: a system for functional studies of the presenilin/gamma-secretase complex

5 July 2018

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5 July 2018

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Glu-333 of nicastrin directly participates in gamma-secretase activity

5 July 2018

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5 July 2018

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Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution

5 July 2018

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Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements

5 July 2018

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5 July 2018

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5 July 2018

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When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease

5 July 2018

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Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores

5 July 2018

1 reference

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Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1

5 July 2018

1 reference

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Evidence that the "NF" motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2.

5 July 2018

1 reference

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Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components

5 July 2018

1 reference

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5 July 2018

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5 July 2018

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Purification and characterization of the human gamma-secretase complex

5 July 2018

1 reference

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Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

5 July 2018

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5 July 2018

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γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

5 July 2018

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5 July 2018

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5 July 2018

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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

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APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

5 July 2018

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5 July 2018

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

5 July 2018

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5 July 2018

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5 July 2018

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Reconstitution of gamma-secretase activity

5 July 2018

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Nicastrin functions as a gamma-secretase-substrate receptor

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.1414837111

Nicastrin overexpression in transgenic mice induces aberrant behavior and APP processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1414837111

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1414837111

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1414837111

Three-dimensional structure of the γ-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1414837111

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25197054

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1414837111

1 reference

31 July 2017

0 references

1 reference

31 July 2017

1 reference