(Q50748297)

18 March 2018

title

Nicastrin overexpression in transgenic mice induces aberrant behavior and APP processing. (English)

1 reference

18 March 2018

1 reference

Jun Seo Goo

1

1 reference

18 March 2018

Yong Bin Kim

2

1 reference

18 March 2018

Sun Bo Shim

3

1 reference

18 March 2018

Seung Wan Jee

4

1 reference

18 March 2018

Su Hae Lee

5

1 reference

18 March 2018

Ji Een Kim

6

1 reference

18 March 2018

In Sik Hwang

7

1 reference

18 March 2018

Young Ju Lee

8

1 reference

18 March 2018

Moon Hwa Kwak

9

1 reference

18 March 2018

Chuel Ju Lim

10

1 reference

18 March 2018

Jin Tae Hong

11

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18 March 2018

Dae Youn Hwang

12

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18 March 2018

publication date

18 April 2013

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18 March 2018

published in

Molecular Neurobiology

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18 March 2018

volume

48

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18 March 2018

issue

1

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18 March 2018

page(s)

232-243

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18 March 2018

https://scigraph.springernature.com/pub.10.1007/s12035-013-8453-3

exact match

0 references

cites work

Nicastrin functions as a gamma-secretase-substrate receptor

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

Presenilin is required for activity and nuclear access of Notch in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

Localization of presenilin-nicastrin complexes and gamma-secretase activity to the trans-Golgi network

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

Place navigation impaired in rats with hippocampal lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

Upregulation of albumin expression in focal ischemic rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

Aberrant expressions of pathogenic phenotype in Alzheimer's diseased transgenic mice carrying NSE-controlled APPsw.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

NSE-controlled carboxyl-terminus of APP gene over-expressing in transgenic mice induces altered expressions in behavior, Abeta-42, and GSK3beta binding proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

PEN-2 overexpression induces gamma-secretase protein and its activity with amyloid beta-42 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

Loss of nicastrin elicits an apoptotic phenotype in mouse embryos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

Curcumin induces cell death in esophageal cancer cells through modulating Notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

Transgenic mice expressing beta-galactosidase in mature neurons under neuron-specific enolase promoter control

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

Assembly, trafficking and function of gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

Endogenous IL-4 and IFN-γ are essential for expression of Th2, but not Th1 cytokine message during the early differentiation of human CD4+ T helper cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8453-3

Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23595812

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Overexpression of nicastrin increases Aß production

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23595812

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23595812

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S12035-013-8453-3

1 reference

18 March 2018

PubMed ID

23595812

1 reference

18 March 2018