(Q40151024)

18 September 2017

PEN-2 overexpression induces gamma-secretase protein and its activity with amyloid beta-42 production (English)

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18 September 2017

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Su J Seo

1

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18 September 2017

Dae Y Hwang

2

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18 September 2017

Jung S Cho

3

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18 September 2017

Kab R Chae

4

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18 September 2017

Chuel K Kim

5

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18 September 2017

Sun B Shim

6

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18 September 2017

Seung W Jee

7

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18 September 2017

Su H Lee

8

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18 September 2017

Ji S Sin

9

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18 September 2017

Soo Y Choi

10

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18 September 2017

Joon Kim

11

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18 September 2017

Yong K Kim

12

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18 September 2017

31 March 2007

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18 September 2017

Neurochemical Research

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18 September 2017

32

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18 September 2017

6

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18 September 2017

1016-1023

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https://scigraph.springernature.com/pub.10.1007/s11064-006-9262-0

18 September 2017

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cites work

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

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12 December 2020

Aberrant expressions of pathogenic phenotype in Alzheimer's diseased transgenic mice carrying NSE-controlled APPsw.

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12 December 2020

The role of presenilin cofactors in the gamma-secretase complex

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12 December 2020

Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex

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12 December 2020

Overexpression of nicastrin increases Aß production

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12 December 2020

Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation

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12 December 2020

Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP).

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12 December 2020

Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes

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12 December 2020

Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

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12 December 2020

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

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12 December 2020

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

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12 December 2020

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

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12 December 2020

Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer's disease.

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12 December 2020

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

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12 December 2020

Tau and GSK3beta dephosphorylations are required for regulating Pin1 phosphorylation.

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12 December 2020

Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin

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12 December 2020

10.1007/S11064-006-9262-0

Identifiers

DOI

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Dimensions Publication ID

18 September 2017

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