(Q40656027)

22 September 2017

Overexpression of nicastrin increases Abeta production (English)

1 reference

22 September 2017

Overexpression of nicastrin increases Aß production (English)

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

23 December 2023

1 reference

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

23 December 2023

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

23 December 2023

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

23 December 2023

author name string

Pritam Das

2

1 reference

22 September 2017

Chris McLendon

8

1 reference

22 September 2017

M. Paul Murphy

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12692078

23 December 2023

Andrew C. Nyborg

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12692078

23 December 2023

Marjorie J. Rochette

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12692078

23 December 2023

Mark W. Dodson

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12692078

23 December 2023

Nicole M. Loosbrock

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12692078

23 December 2023

Terrance M. Souder

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12692078

23 December 2023

Sami L. Merit

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12692078

23 December 2023

Siân C. Piper

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12692078

23 December 2023

Karen R. Jansen

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12692078

23 December 2023

Todd E. Golde

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12692078

23 December 2023

language of work or name

English

0 references

publication date

8 April 2003

1 reference

full work available at URL

22 September 2017

http://www.fasebj.org/cgi/content/abstract/17/9/1138

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12692078

https://onlinelibrary.wiley.com/doi/pdf/10.1096/fj.02-1050fje

23 December 2023

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

https://onlinelibrary.wiley.com/doi/full-xml/10.1096/fj.02-1050fje

23 December 2023

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

23 December 2023

1 reference

22 September 2017

17

1 reference

22 September 2017

9

1 reference

22 September 2017

1138-1140

1 reference

Alzheimer's disease: genes, proteins, and therapy

22 September 2017

1

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Amyloid beta-peptide is produced by cultured cells during normal metabolism

23 December 2023

2

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

23 December 2023

3

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

23 December 2023

4

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

23 December 2023

5

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

23 December 2023

6

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

23 December 2023

7

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

23 December 2023

8

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

23 December 2023

9

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

FAD-linked mutations in presenilin 1 alter the length of Abeta peptides derived from betaAPP transmembrane domain mutants

23 December 2023

10

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

23 December 2023

11

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

23 December 2023

12

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

23 December 2023

13

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Presenilin is required for activity and nuclear access of Notch in Drosophila

23 December 2023

14

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

23 December 2023

15

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

23 December 2023

16

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

23 December 2023

17

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

23 December 2023

18

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

23 December 2023

19

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Estimation of the Genetic Contribution of Presenilin-1 and -2 Mutations in a Population-Based Study of Presenile Alzheimer Disease

23 December 2023

20

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

23 December 2023

21

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

23 December 2023

22

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

23 December 2023

23

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

23 December 2023

24

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Identification of a novel family of presenilin homologues

23 December 2023

25

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Identification of signal peptide peptidase, a presenilin-type aspartic protease

23 December 2023

26

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

23 December 2023

27

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

23 December 2023

28

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

23 December 2023

29

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

23 December 2023

30

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

23 December 2023

31

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Nicastrin binds to membrane-tethered Notch

23 December 2023

32

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

APH-2/nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad.

23 December 2023

33

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

23 December 2023

34

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

23 December 2023

35

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Drosophila nicastrin is essential for the intramembranous cleavage of notch

23 December 2023

36

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

The Alzheimer beta-amyloid protein precursor/protease nexin-II is cleaved by secretase in a trans-Golgi secretory compartment in human neuroglioma cells

23 December 2023

37

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells

23 December 2023

38

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Flemish and Dutch mutations in amyloid beta precursor protein have different effects on amyloid beta secretion

23 December 2023

39

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Matrix protein mutations contribute to inefficient induction of apoptosis leading to persistent infection of human neural cells by vesicular stomatitis virus

23 December 2023

40

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Tau assembly in inducible transfectants expressing wild-type or FTDP-17 tau.

23 December 2023

41

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43).

23 December 2023

42

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

23 December 2023

43

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

23 December 2023

44

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

23 December 2023

45

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Cell-free assays for gamma-secretase activity

23 December 2023

46

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein

23 December 2023

47

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

23 December 2023

48

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

23 December 2023

49

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.

23 December 2023

50

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization

23 December 2023

51

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample

23 December 2023

52

1 reference

https://api.crossref.org/works/10.1096/FJ.02-1050FJE

23 December 2023

Identifiers

0 references

1 reference