(Q43963328)

28 November 2017

title

FAD-linked mutations in presenilin 1 alter the length of Abeta peptides derived from betaAPP transmembrane domain mutants (English)

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28 November 2017

main subject

transmembrane protein

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author name string

M Paul Murphy

1

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28 November 2017

Sacha N Uljon

2

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28 November 2017

Todd E Golde

3

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28 November 2017

Rong Wang

4

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28 November 2017

publication date

1 March 2002

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28 November 2017

number of pages

11

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Biochimica et Biophysica Acta

inferred from page(s)

published in

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28 November 2017

volume

1586

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28 November 2017

issue

2

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28 November 2017

page(s)

199-209

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Amyloid beta-peptide is produced by cultured cells during normal metabolism

28 November 2017

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

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7 January 2021

Estimation of the Genetic Contribution of Presenilin-1 and -2 Mutations in a Population-Based Study of Presenile Alzheimer Disease

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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7 January 2021

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

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7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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7 January 2021

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

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7 January 2021

Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease

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7 January 2021

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

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7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

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7 January 2021

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

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7 January 2021

Effects of PS1 deficiency on membrane protein trafficking in neurons

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7 January 2021

Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin

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7 January 2021

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

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7 January 2021

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

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7 January 2021

Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell death

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7 January 2021

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

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7 January 2021

Alzheimer's presenilin 1 is a putative membrane receptor for rab GDP dissociation inhibitor

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7 January 2021

Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts

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7 January 2021

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

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7 January 2021

A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

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7 January 2021

Calsenilin reverses presenilin-mediated enhancement of calcium signaling

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7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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7 January 2021

The presenilins in Alzheimer's disease--proteolysis holds the key.

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7 January 2021

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

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7 January 2021

A combinatorial approach to the identification of dipeptide aldehyde inhibitors of beta-amyloid production

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7 January 2021

The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities

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7 January 2021

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

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7 January 2021

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

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7 January 2021

Cell-free assays for gamma-secretase activity

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7 January 2021

The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

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7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

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7 January 2021

The presenilin 1 C92S mutation increases abeta 42 production.

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7 January 2021

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

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7 January 2021

The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

1 reference

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7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

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7 January 2021

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1 reference

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7 January 2021

10.1016/S0925-4439(01)00098-9

Identifiers

DOI

1 reference

28 November 2017

1 reference