(Q35037737)

5 August 2017

Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes (English)

1 reference

5 August 2017

Ching-Ju Tsai

3

0 references

Muriel Arimon

Muriel Arimon

11

0 references

Roger B Dodd

Roger B Dodd

6

0 references

Taisuke Tomita

Taisuke Tomita

Peter Henry St George-Hyslop

14

0 references

Peter H St George-Hyslop

20

0 references

Lindsay A. Farrer

Lindsay A Farrer

17

0 references

Bradley Hyman

13

Bradley T Hyman

1 reference

5 August 2017

18

Gerold Schmitt-Ulms

1 reference

5 August 2017

Yi Li

1

1 reference

5 August 2017

Stephen Hsueh-Jeng Lu

2

1 reference

5 August 2017

Christopher Bohm

4

1 reference

5 August 2017

Seema Qamar

5

1 reference

5 August 2017

William Meadows

7

1 reference

5 August 2017

Amy Jeon

8

1 reference

5 August 2017

Adam McLeod

9

1 reference

5 August 2017

Fusheng Chen

10

1 reference

5 August 2017

Oksana Berezovska

12

1 reference

5 August 2017

Takeshi Iwatsubo

15

1 reference

5 August 2017

Christopher M Johnson

16

1 reference

5 August 2017

Paul E Fraser

19

1 reference

5 August 2017

7 November 2013

1 reference

5 August 2017

1 reference

5 August 2017

22

1 reference

5 August 2017

1

1 reference

5 August 2017

125-135

1 reference

describes a project that uses

5 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3887256/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Spike bursts increase amyloid-β 40/42 ratio by inducing a presenilin-1 conformational change

1 reference

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Molecular assembly of botulinum neurotoxin progenitor complexes

8 July 2018

1 reference

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Structure of a presenilin family intramembrane aspartate protease

8 July 2018

1 reference

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Regulation of mammalian transcription by Gdown1 through a novel steric crosstalk revealed by cryo-EM

8 July 2018

1 reference

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Outcome of the first electron microscopy validation task force meeting

8 July 2018

1 reference

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γ-Secretase inhibitors and modulators for Alzheimer's disease

8 July 2018

1 reference

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A Bayesian view on cryo-EM structure determination.

8 July 2018

1 reference

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Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1

8 July 2018

1 reference

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Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

Single particle electron microscopy reconstruction of the exosome complex using the random conical tilt method

8 July 2018

1 reference

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Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase.

8 July 2018

1 reference

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Single-particle reconstruction of biological macromolecules in electron microscopy--30 years

8 July 2018

1 reference

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Rhomboid protease dynamics and lipid interactions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

Image processing for electron microscopy single-particle analysis using XMIPP.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

The Role of L1 Loop in the Mechanism of Rhomboid Intramembrane Protease GlpG

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

An efficient tandem affinity purification procedure for interaction proteomics in mammalian cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

The initial substrate-binding site of gamma-secretase is located on presenilin near the active site

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

XMIPP: a new generation of an open-source image processing package for electron microscopy.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

UCSF Chimera--a visualization system for exploratory research and analysis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

Optimal determination of particle orientation, absolute hand, and contrast loss in single-particle electron cryomicroscopy

8 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

8 July 2018

12 December 2020

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

Three-dimensional structure of NADH-dehydrogenase from Neurospora crassa by electron microscopy and conical tilt reconstruction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

Three-dimensional reconstruction from a single-exposure, random conical tilt series applied to the 50S ribosomal subunit of Escherichia coli

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

Alzheimer's disease: Selectively tuning gamma-secretase.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

Single particle reconstructions of the transferrin-transferrin receptor complex obtained with different specimen preparation techniques

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

Nicastrin functions as a gamma-secretase-substrate receptor

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

The mechanism of gamma-secretase: multiple inhibitor binding sites for transition state analogs and small molecule inhibitors

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

Divergent Synthesis of Multifunctional Molecular Probes To Elucidate the Enzyme Specificity of Dipeptidic γ-Secretase Inhibitors

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887256

Three-dimensional structure of the γ-secretase complex

9 December 2018

1 reference

PubMed

12 December 2020

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

1 reference

PubMed

12 December 2020

The three-dimensional arcitecture of the EJC core

1 reference

PubMed

12 December 2020

10.1016/J.STR.2013.09.018

Identifiers

DOI

1 reference

5 August 2017

1 reference

5 August 2017

1 reference