(Q34227176)

31 July 2017

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title

Anti-TNF-alpha therapies: the next generation (English)

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31 July 2017

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4

Lyle L Moldawer

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31 July 2017

Michael A Palladino

1

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31 July 2017

Frances Rena Bahjat

series ordinal

2

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31 July 2017

Emmanuel A Theodorakis

series ordinal

3

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31 July 2017

publication date

1 September 2003

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Nature Reviews Drug Discovery

31 July 2017

published in

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31 July 2017

volume

2

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31 July 2017

issue

9

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31 July 2017

page(s)

736-746

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An endotoxin-induced serum factor that causes necrosis of tumors

31 July 2017

cites work

1 reference

Coley's toxins, tumor necrosis factor and cancer research: a historical perspective

31 March 2020

1 reference

Studies of endotoxin-induced decrease in lipoprotein lipase activity

31 March 2020

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Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells

31 March 2020

1 reference

Identity of tumour necrosis factor and the macrophage-secreted factor cachectin

31 March 2020

1 reference

Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor

31 March 2020

1 reference

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

31 March 2020

1 reference

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF

31 March 2020

1 reference

A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling

31 March 2020

1 reference

In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis

31 March 2020

1 reference

Lipopolysaccharide and D-galactosamine-induced hepatic injury is mediated by TNF-alpha and not by Fas ligand

31 March 2020

1 reference

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha

31 March 2020

1 reference

An essential role for ectodomain shedding in mammalian development

31 March 2020

1 reference

Protective effect of 55- but not 75-kD soluble tumor necrosis factor receptor-immunoglobulin G fusion proteins in an animal model of gram-negative sepsis

31 March 2020

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The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor

31 March 2020

1 reference

Tumor necrosis factor (TNF) receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1

31 March 2020

1 reference

Supraoptimal peptide-major histocompatibility complex causes a decrease in bc1-2 levels and allows tumor necrosis factor alpha receptor II-mediated apoptosis of cytotoxic T lymphocytes

31 March 2020

1 reference

Induction of apoptosis in mature T cells by tumour necrosis factor

31 March 2020

1 reference

Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo

31 March 2020

1 reference

A human inhibitor of tumor necrosis factor alpha

31 March 2020

1 reference

Isolation and characterization of a tumor necrosis factor binding protein from urine

31 March 2020

1 reference

A critical role of the p75 tumor necrosis factor receptor (p75TNF-R) in organ inflammation independent of TNF, lymphotoxin alpha, or the p55TNF-R.

31 March 2020

1 reference

Cytokine production in synovial tissue of mice with collagen-induced arthritis (CIA)

31 March 2020

1 reference

Uncoupling of inflammatory and destructive mechanisms in arthritis

31 March 2020

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The type I interleukin-1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF-transgenic mice

31 March 2020

1 reference

Tumour necrosis factor in synovial exudates

31 March 2020

1 reference

Detection of tumor necrosis factor alpha but not tumor necrosis factor beta in rheumatoid arthritis synovial fluid and serum

31 March 2020

1 reference

Immune response to a recombinant human TNFR55-IgG1 fusion protein: auto-antibodies in rheumatoid arthritis (RA) and multiple sclerosis (MS) patients have neither neutralizing nor agonist activities

31 March 2020

1 reference

Disease activity and risk of lymphoma in patients with rheumatoid arthritis: nested case-control study

31 March 2020

1 reference

Lymphoma subtypes in patients with rheumatoid arthritis: increased proportion of diffuse large B cell lymphoma

31 March 2020

1 reference

Risk of malignant lymphomas in patients with rheumatoid arthritis and in their first-degree relatives

31 March 2020

1 reference

Thalidomide in the treatment of relapsed multiple myeloma

31 March 2020

1 reference

A review of angiogenesis and antiangiogenic therapy with thalidomide in multiple myeloma.

31 March 2020

1 reference

Thalidomide for previously untreated indolent or smoldering multiple myeloma

31 March 2020

1 reference

Species differences in pharmacokinetics and drug teratogenesis

31 March 2020

1 reference

Down-regulation of adhesion receptors on cells of primate embryos as a probable mechanism of the teratogenic action of thalidomide

31 March 2020

1 reference

Embryotoxic effects of thalidomide derivatives in the non-human primate Callithrix jacchus. II. Elucidation of the susceptible period and of the variability of embryonic stages.

31 March 2020

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Embryotoxic effects of thalidomide derivatives in the non-human primate Callithrix jacchus. 5. Lack of teratogenic effects of phthalimidophthalmide

31 March 2020

1 reference

Protective antitumor immunity induced by a costimulatory thalidomide analog in conjunction with whole tumor cell vaccination is mediated by increased Th1-type immunity

31 March 2020

1 reference

Novel thalidomide analogues display anti-angiogenic activity independently of immunomodulatory effects

31 March 2020

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Thalidomide analogs as emerging anti-cancer drugs

31 March 2020

1 reference

Recent advances in PDE4 inhibitors as immunoregulators and anti-inflammatory drugs

31 March 2020

1 reference

Theophylline and PDE4 inhibitors in asthma.

31 March 2020

1 reference

Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat

31 March 2020

1 reference

Differential effects between marimastat, a TNF-alpha converting enzyme inhibitor, and anti-TNF-alpha antibody on murine models for sepsis and arthritis

31 March 2020

1 reference

Role of IkappaBalpha ubiquitination in signal-induced activation of NFkappaB in vivo

31 March 2020

1 reference

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

31 March 2020

1 reference

Signaling molecules of the NF-kappa B pathway shuttle constitutively between cytoplasm and nucleus.

31 March 2020

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Role of IKK1 and IKK2 in lipopolysaccharide signaling in human monocytic cells

31 March 2020

1 reference

First proteasome inhibitor approved for multiple myeloma

31 March 2020

1 reference

Kaurane diterpene, kamebakaurin, inhibits NF-kappa B by directly targeting the DNA-binding activity of p50 and blocks the expression of antiapoptotic NF-kappa B target genes

31 March 2020

1 reference

Kaurane diterpenes from Isodon japonicus inhibit nitric oxide and prostaglandin E2 production and NF-kappaB activation in LPS-stimulated macrophage RAW264.7 cells

31 March 2020

1 reference

Inhibition of the NF-kappaB signaling pathway mediates the anti-inflammatory effects of petrosaspongiolide M.

31 March 2020

1 reference

Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta

31 March 2020

1 reference

Parthenolide, an inhibitor of the nuclear factor-kappaB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents

31 March 2020

1 reference

The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase

31 March 2020

1 reference

Suppression by a sesquiterpene lactone from Carpesium divaricatum of inducible nitric oxide synthase by inhibiting nuclear factor-kappaB activation

31 March 2020

1 reference

Anthralin stimulates keratinocyte-derived proinflammatory cytokines via generation of reactive oxygen species

31 March 2020

1 reference

Iron and reactive oxygen species in the asbestos-induced tumor necrosis factor-alpha response from alveolar macrophages

31 March 2020

1 reference

BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice

31 March 2020

1 reference

Calagualine inhibits nuclear transcription factors-kappaB activated by various inflammatory and tumor promoting agents

31 March 2020

1 reference

Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway

31 March 2020

1 reference

31 March 2020

The inflammatory reflex

1 reference

31 March 2020

1 reference

The alveolar macrophage: the Trojan horse of Bacillus anthracis

31 March 2020

1 reference

Lethal toxin actions and their consequences.

31 March 2020

1 reference

On the role of macrophages in anthrax

31 March 2020

1 reference

31 March 2020

1 reference

Identification of the cellular receptor for anthrax toxin

31 March 2020

1 reference

Crystal structure of the anthrax toxin protective antigen

31 March 2020

1 reference

Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells

31 March 2020

1 reference

Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor

31 March 2020

1 reference

Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition

31 March 2020

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Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor

31 March 2020

1 reference

Anthrax lethal factor cleaves the N-terminus of MAPKKS and induces tyrosine/threonine phosphorylation of MAPKS in cultured macrophages

31 March 2020

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Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFNgamma-induced release of NO and TNFalpha

31 March 2020

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Proteasome activity is required for anthrax lethal toxin to kill macrophages

31 March 2020

1 reference

Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11.

31 March 2020

1 reference

Pathogenesis and genetic control of resistance to the Sterne strain of Bacillus anthracis.

31 March 2020

1 reference

Comparative safety and efficacy against Bacillus anthracis of protective antigen and live vaccines in mice

31 March 2020

1 reference

Kif1C, a kinesin-like motor protein, mediates mouse macrophage resistance to anthrax lethal factor

31 March 2020

1 reference

Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-alpha

31 March 2020

1 reference

Phosphodiesterase 4 (PDE4) inhibitors in asthma and chronic obstructive pulmonary disease (COPD).

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1175

1 reference

31 July 2017

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