(Q34236070)

31 July 2017

title

The G2019S pathogenic mutation disrupts sensitivity of leucine-rich repeat kinase 2 to manganese kinase inhibition (English)

1 reference

31 July 2017

Jason P Covy

1

1 reference

31 July 2017

Benoit I Giasson

series ordinal

2

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31 July 2017

language of work or name

English

0 references

publication date

19 August 2010

1 reference

Journal of Neurochemistry

31 July 2017

published in

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31 July 2017

volume

115

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31 July 2017

issue

1

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31 July 2017

page(s)

36-46

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describes a project that uses

31 July 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2963190/fullTextXML

inferred from PubMed Central ID database lookup

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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A second magnesium ion is critical for ATP binding in the kinase domain of the oncoprotein v-Fps

6 July 2018

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Requirement for an additional divalent metal cation to activate protein tyrosine kinases.

6 July 2018

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Crystal structure of cyclin-dependent kinase 2

6 July 2018

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Mutational analyses of the metal ion and substrate binding sites of phosphorylase kinase gamma subunit.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963190

Three protein kinase structures define a common motif

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963190

Enzyme-Catalyzed Phosphoryl Transfer Reactions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963190

Parkinsonism: onset, progression, and mortality

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963190

Properties of neurofilament protein kinase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963190

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963190

6 July 2018

Protein-tyrosine kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963190

Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963190

Activation of the EGF receptor tyrosine kinase by divalent metal ions: comparison of holoreceptor and isolated kinase domain properties

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963190

Differential effects of divalent manganese and magnesium on the kinase activity of leucine-rich repeat kinase 2 (LRRK2).

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963190

Leucine-rich repeat kinase 2 mutants I2020T and G2019S exhibit altered kinase inhibitor sensitivity.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963190

Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963190

LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963190

Did protein kinase regulatory mechanisms evolve through elaboration of a simple structural component?

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963190

A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963190

Structure of the mammalian catalytic subunit of cAMP-dependent protein kinase and an inhibitor peptide displays an open conformation

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963190

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963190

Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963190

LRRK2 gene in Parkinson disease: Mutation analysis and case control association study

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963190

A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease

28 October 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.06894.X

21 January 2018

Genetics of parkinsonism

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12 December 2020

Phosphorylase kinase, a metal ion-dependent dual specificity kinase

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12 December 2020

Genetic and clinical identification of Parkinson's disease patients with LRRK2 G2019S mutation

1 reference

12 December 2020

LRRK2G2019S as a Cause of Parkinson's Disease in North African Arabs

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12 December 2020

Non-receptor cytosolic protein tyrosine kinases from various rat tissues

1 reference

12 December 2020

Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease

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12 December 2020

10.1111/J.1471-4159.2010.06894.X

Identifiers

DOI

1 reference

31 July 2017

1 reference

31 July 2017

1 reference