(Q37315448)

19 August 2017

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title

Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis (English)

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19 August 2017

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2

M Flint Beal

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19 August 2017

Claire Henchcliffe

1

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19 August 2017

1 November 2008

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Nature Clinical Practice Neurology

19 August 2017

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19 August 2017

4

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19 August 2017

600-609

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19 August 2017

11

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Mitochondria in the aetiology and pathogenesis of Parkinson's disease

19 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Mitochondrial complex I deficiency in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Complex I deficiency in Parkinson's disease frontal cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Origin and functional consequences of the complex I defect in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Cortical dysfunction in non-demented Parkinson's disease patients: a combined (31)P-MRS and (18)FDG-PET study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Oxidative stress in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Metabolomic profiling to develop blood biomarkers for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Plasma urate and risk of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

The pathophysiology of mitochondrial cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Dopamine D2-type agonists protect mesencephalic neurons from glutamate neurotoxicity: mechanisms of neuroprotective treatment against oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Chronic exposure to rotenone models sporadic Parkinson's disease in Drosophila melanogaster.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Systemic exposure to paraquat and maneb models early Parkinson's disease in young adult rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Antiparkinsonian effects of remacemide hydrochloride, a glutamate antagonist, in rodent and primate models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Matrilineal inheritance of complex I dysfunction in a multigenerational Parkinson's disease family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Maternal inheritance in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Double-strand breaks of mouse muscle mtDNA promote large deletions similar to multiple mtDNA deletions in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Mitochondrial association of alpha-synuclein causes oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Functional mitochondria are required for alpha-synuclein toxicity in aging yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Parkinson's disease: mechanisms and models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Parkin enhances mitochondrial biogenesis in proliferating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

The PINK1/Parkin pathway regulates mitochondrial morphology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Mitochondria, the killer organelles and their weapons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Coenzyme Q10 reduces the toxicity of rotenone in neuronal cultures by preserving the mitochondrial membrane potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Short-term effects of coenzyme Q10 in progressive supranuclear palsy: a randomized, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Mice lacking alpha-synuclein are resistant to mitochondrial toxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Neuroprotective effects of resveratrol on MPTP-induced neuron loss mediated by free radical scavenging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

PINK1 protein in normal human brain and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

DJ-1 has a role in antioxidative stress to prevent cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

Generalized mitochondrial dysfunction in Parkinson's disease detected by magnetic resonance spectroscopy of muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

7 January 2021

Parkinson's disease and brain mitochondrial dysfunction: a functional phosphorus magnetic resonance spectroscopy study

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

7 January 2021

Excitotoxicity and nitric oxide in Parkinson's disease pathogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

7 January 2021

Familial multisystem degeneration with parkinsonism associated with the 11778 mitochondrial DNA mutation

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

7 January 2021

Paraquat induces oxidative stress and neuronal cell death; neuroprotection by water-soluble Coenzyme Q10

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

7 January 2021

A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

7 January 2021

A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

7 January 2021

A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

7 January 2021

The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

7 January 2021

Induction of alpha-synuclein aggregation by intracellular nitrative insult.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0924

7 January 2021

Identifiers

DOI

10.1038/NCPNEURO0924

1 reference

19 August 2017

1 reference

PubMed ID

18978800