(Q35891905)

11 August 2017

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title

Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment (English)

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11 August 2017

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1

M Flint Beal

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11 August 2017

1 August 2004

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Journal of Bioenergetics and Biomembranes

11 August 2017

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11 August 2017

36

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11 August 2017

381-386

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11 August 2017

4

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https://scigraph.springernature.com/pub.10.1023/b:jobb.0000041772.74810.92

11 August 2017

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cites work

Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate

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12 December 2020

Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

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12 December 2020

Oxidative stress increases expression and activity of BACE in NT2 neurons

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12 December 2020

Superoxide activates mitochondrial uncoupling proteins

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12 December 2020

Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of beta-amyloid-mediated cell death

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12 December 2020

Systemic increase of oxidative nucleic acid damage in Parkinson's disease and multiple system atrophy

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12 December 2020

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

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12 December 2020

Brain, skeletal muscle and platelet homogenate mitochondrial function in Parkinson's disease

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12 December 2020

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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12 December 2020

An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.

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12 December 2020

A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group

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12 December 2020

Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain

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12 December 2020

Detection of nitrosyl complexes in human substantia nigra, in relation to Parkinson's disease.

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12 December 2020

Ubiquinone protects cultured neurons against spontaneous and excitotoxin-induced degeneration

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12 December 2020

Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome

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12 December 2020

Familial multisystem degeneration with parkinsonism associated with the 11778 mitochondrial DNA mutation

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12 December 2020

A novel mitochondrial 12SrRNA point mutation in parkinsonism, deafness, and neuropathy.

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12 December 2020

Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease

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12 December 2020

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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12 December 2020

A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study.

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12 December 2020

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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12 December 2020

Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in Parkinson's disease.

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12 December 2020

The amyloid beta protein induces oxidative damage of mitochondrial DNA.

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12 December 2020

Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease

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12 December 2020

Novel mitochondrial DNA mutations in Parkinson's disease

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12 December 2020

Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: an HPLC and ESR study

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12 December 2020

Oxidative damage and cytogenetic analysis in leukocytes of Parkinson's disease patients.

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12 December 2020

Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects

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12 December 2020

Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative

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12 December 2020

Presenile dementia and Alzheimer's disease in mongolism.

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12 December 2020

Presenilin-1 is associated with Alzheimer's disease amyloid

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12 December 2020

Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death.

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12 December 2020

Oxidative damage is the earliest event in Alzheimer disease

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12 December 2020

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

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12 December 2020

Suppression of mitochondrial succinate dehydrogenase, a primary target of beta-amyloid, and its derivative racemized at Ser residue.

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12 December 2020

Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities

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12 December 2020

Assessment of coenzyme Q10 tolerability in Huntington's disease

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12 December 2020

Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease

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12 December 2020

Mitochondrial Polymorphisms Significantly Reduce the Risk of Parkinson Disease

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12 December 2020

An analysis of the role of coenzyme Q in free radical generation and as an antioxidant

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12 December 2020

Coenzyme q10 prevents apoptosis by inhibiting mitochondrial depolarization independently of its free radical scavenging property.

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12 December 2020

Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease.

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12 December 2020

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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12 December 2020

Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma

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12 December 2020

Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.

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12 December 2020

Energy metabolism defects in Huntington's disease and effects of coenzyme Q10.

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12 December 2020

Parkinson's disease: a disorder due to nigral glutathione deficiency?

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12 December 2020

A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease.

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12 December 2020

Origin and functional consequences of the complex I defect in Parkinson's disease

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12 December 2020

The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease.

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12 December 2020

Effect of coenzyme Q(10) on biochemical and morphological changes in experimental ischemia in the rat brain.

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12 December 2020

Oxidative stress in Parkinson's disease

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12 December 2020

Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E.

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12 December 2020

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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12 December 2020

Mitochondrial complex I deficiency in Parkinson's disease

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12 December 2020

Selective increase in cellular A beta 42 is related to apoptosis but not necrosis.

1 reference

12 December 2020

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

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12 December 2020

Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline

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12 December 2020

Abnormality of the alpha-ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease.

1 reference

12 December 2020

Effect of idebenone on cardiomyopathy in Friedreich's ataxia: a preliminary study

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12 December 2020

Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients.

1 reference

12 December 2020

Altered calcium homeostasis in cells transformed by mitochondria from individuals with Parkinson's disease

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12 December 2020

Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease

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12 December 2020

Protein nitration in Parkinson's disease.

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12 December 2020

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

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12 December 2020

Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

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12 December 2020

Induction of alpha-synuclein aggregation by intracellular nitrative insult.

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12 December 2020

Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis.

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12 December 2020

Mitochondrial DNA deletions/rearrangements in parkinson disease and related neurodegenerative disorders.

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12 December 2020

Idebenone and reduced cardiac hypertrophy in Friedreich's ataxia

1 reference

12 December 2020

Unaltered aconitase activity, but decreased complex I activity in substantia nigra pars compacta of patients with Parkinson's disease.

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12 December 2020

Mitochondrial DNA mutations in complex I and tRNA genes in Parkinson's disease

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12 December 2020

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1 reference

12 December 2020

Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo

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12 December 2020

An out-of-frame cytochrome b gene deletion from a patient with parkinsonism is associated with impaired complex III assembly and an increase in free radical production

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12 December 2020

Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice

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12 December 2020

Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress.

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12 December 2020

Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid beta-peptide (1-42) in a transgenic Caenorhabditis elegans model.

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12 December 2020

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

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12 December 2020

The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse.

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12 December 2020

Metabolic enzyme expression in dopaminergic neurons in Parkinson's disease: an in situ hybridization study

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12 December 2020

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12 December 2020

Relations between tocopherol depletion and coenzyme Q during lipid peroxidation in rat liver mitochondria

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12 December 2020

Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome

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12 December 2020

Regulation of ubiquinone metabolism

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12 December 2020

A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease

1 reference

12 December 2020

Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons

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12 December 2020

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease

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12 December 2020

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

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12 December 2020

Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease

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12 December 2020

Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease

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12 December 2020

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro.

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12 December 2020

Coenzyme Q is an obligatory cofactor for uncoupling protein function

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12 December 2020

Antioxidant treatment improves in vivo cardiac and skeletal muscle bioenergetics in patients with Friedreich's ataxia

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12 December 2020

Mitochondrial abnormalities in Alzheimer's disease.

1 reference

12 December 2020

10.1023/B:JOBB.0000041772.74810.92

Identifiers

DOI

1 reference

PubMed ID

15377876

Dimensions Publication ID

11 August 2017

0 references

1 reference

PubMed ID

15377876