(Q42524820)

1 November 2017

An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757862&resulttype=core&format=json

12 May 2020

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7

Mark R Cookson

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1 November 2017

Todd B Sherer

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757862&resulttype=core&format=json

12 May 2020

Ranjita Betarbet

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757862&resulttype=core&format=json

12 May 2020

Amy K Stout

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757862&resulttype=core&format=json

12 May 2020

Serena Lund

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757862&resulttype=core&format=json

12 May 2020

Melisa Baptista

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757862&resulttype=core&format=json

12 May 2020

Alexander V Panov

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757862&resulttype=core&format=json

12 May 2020

J Timothy Greenamyre

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757862&resulttype=core&format=json

12 May 2020

Mark R Cookson

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757862&resulttype=core&format=json

12 May 2020

language of work or name

English

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publication date

1 August 2002

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1 November 2017

Journal of Neuroscience

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757862&resulttype=core&format=json

12 May 2020

volume

22

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757862&resulttype=core&format=json

12 May 2020

page(s)

7006-7015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757862&resulttype=core&format=json

12 May 2020

issue

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757862&resulttype=core&format=json

Hydrogen peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive oxygen species and the activation of NF-kappaB.

12 May 2020

cites work

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12 December 2020

Cell death and apoptosis regulating proteins in Parkinson's disease--a cautionary note.

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12 December 2020

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12 December 2020

Oxidative mechanisms in nigral cell death in Parkinson's disease.

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12 December 2020

Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease

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12 December 2020

Parkinson's disease, pesticides, and glutathione transferase polymorphisms

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12 December 2020

Cyclosporin inhibition of apoptosis induced by mitochondrial complex I toxins.

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12 December 2020

A fluorescent double-labeling method to detect and confirm apoptotic nuclei in Parkinson's disease.

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12 December 2020

Inhibition of mitochondrial ATP generation by nitric oxide switches apoptosis to necrosis

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12 December 2020

Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies

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12 December 2020

Degradation of alpha-synuclein by proteasome

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12 December 2020

Role of cytochrome c as a stimulator of alpha-synuclein aggregation in Lewy body disease

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12 December 2020

Chronic reduction in complex I function alters calcium signaling in SH-SY5Y neuroblastoma cells

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12 December 2020

Acute mitochondrial and chronic toxicological effects of 1-methyl-4-phenylpyridinium in human neuroblastoma cells

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12 December 2020

alpha-synuclein promotes mitochondrial deficit and oxidative stress

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12 December 2020

Abnormalities of the electron transport chain in idiopathic Parkinson's disease

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12 December 2020

1-Methyl-4-phenylpyridinium (MPP+) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles

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12 December 2020

Alpha-synuclein in Lewy bodies

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12 December 2020

Sources of reactive oxygen species production in excitotoxin- stimulated cerebellar granule cells.

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12 December 2020

The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living

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12 December 2020

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12 December 2020

Protein kinase C inhibits singlet oxygen-induced apoptosis by decreasing caspase-8 activation

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12 December 2020

Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP.

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12 December 2020

Mitochondrial complex I deficiency in Parkinson's disease

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12 December 2020

Substrate specific effects of calcium on metabolism of rat heart mitochondria

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12 December 2020

Programmed cell death: does it play a role in Parkinson's disease?

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12 December 2020

Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease

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12 December 2020

Ethanol stimulates the production of reactive oxygen species at mitochondrial complexes I and III.

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12 December 2020

Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.

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12 December 2020

A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease.

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12 December 2020

Enhanced vulnerability to oxidative stress by alpha-synuclein mutations and C-terminal truncation

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12 December 2020

Increased protein oxidation in human substantia nigra pars compacta in comparison with basal ganglia and prefrontal cortex measured with an improved dinitrophenylhydrazine assay.

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12 December 2020

Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines

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12 December 2020

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

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12 December 2020

The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity

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12 December 2020

Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3beta and attenuated by lithium

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12 December 2020

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

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12 December 2020

Mitochondrial electron transport inhibitors cause lipid peroxidation-dependent and -independent cell death: protective role of antioxidants

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12 December 2020

Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors

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12 December 2020

Mitochondria deficient in complex I activity are depolarized by hydrogen peroxide in nerve terminals: relevance to Parkinson's disease

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12 December 2020

Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form

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12 December 2020

Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease

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12 December 2020

GAPDH knockdown rescues mesencephalic dopaminergic neurons from MPP+ -induced apoptosis

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12 December 2020

Failure of the ubiquitin-proteasome system in Parkinson's disease

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12 December 2020

Caspase 3 inhibition attenuates hydrogen peroxide-induced DNA fragmentation but not cell death in neuronal PC12 cells.

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12 December 2020

The selective toxicity of 1-methyl-4-phenylpyridinium to dopaminergic neurons: the role of mitochondrial complex I and reactive oxygen species revisited.

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12 December 2020

Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells

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12 December 2020

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

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12 December 2020

Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein

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12 December 2020

Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's disease

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12 December 2020

A new link between pesticides and Parkinson's disease.

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12 December 2020

Mitochondrial inhibitors evoke catecholamine release from pheochromocytoma cells.

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12 December 2020

Effect of 1-methyl-4-phenylpyridinium on glutathione in rat pheochromocytoma PC 12 cells.

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12 December 2020

Interaction of alpha-phenyl-N-tert-butyl nitrone and alternative electron acceptors with complex I indicates a substrate reduction site upstream from the rotenone binding site.

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12 December 2020

DeltaPsi(m)-Dependent and -independent production of reactive oxygen species by rat brain mitochondria

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12 December 2020

Dopamine transporter-immunoreactive neurons decrease with age in the human substantia nigra.

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12 December 2020

Alterations in the distribution of glutathione in the substantia nigra in Parkinson's disease

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12 December 2020

Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease

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12 December 2020

Titrating the effects of mitochondrial complex I impairment in the cell physiology

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12 December 2020

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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12 December 2020

10.1523/JNEUROSCI.22-16-07006.2002

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757862&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757862&resulttype=core&format=json

12 May 2020

1 reference