(Q34244620)

31 July 2017

title

The Guanine Nucleotide Exchange Factor Brx: A Link between Osmotic Stress, Inflammation and Organ Physiology and Pathophysiology (English)

1 reference

31 July 2017

1 reference

3

George P Chrousos

1 reference

31 July 2017

Tomoshige Kino

1

1 reference

31 July 2017

James H Segars

series ordinal

2

1 reference

31 July 2017

publication date

1 July 2010

1 reference

Expert review of endocrinology & metabolism

31 July 2017

published in

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31 July 2017

volume

5

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31 July 2017

issue

4

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31 July 2017

page(s)

603-614

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Mechanisms of liver disease: cross-talk between the NF-kappaB and JNK pathways

31 July 2017

cites work

1 reference

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Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes

28 July 2018

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Is inflammation a consequence of extracellular hyperosmolarity?

28 July 2018

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Inflammation and the phenomenology, pathophysiology, comorbidity, and treatment of bipolar disorder: a systematic review of the literature

28 July 2018

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Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism

28 July 2018

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Inflammatory components of adipose tissue as target for treatment of metabolic syndrome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Brx shines a light on the route from hyperosmolarity to NFAT5.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

The immune system and chronic heart failure: is the heart in control?

28 July 2018

1 reference

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Interleukin-6 and insulin resistance

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

NFAT5 induction and its role in hyperosmolar stressed human limbal epithelial cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Lipids and skin barrier function--a clinical perspective

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Mechanical homeostasis is altered in uterine leiomyoma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Organ-specific inflammation following acute ethanol and burn injury

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Cellular response to hyperosmotic stresses

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

The correlation between the tear film lipid layer and dry eye disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Concentration and composition of free amino acids and osmolalities of porcine oviductal and uterine fluid and their effects on development of porcine IVF embryos

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Mechanoregulation of gene expression in fibroblasts

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Mechanical stress-initiated signal transduction in vascular smooth muscle cells in vitro and in vivo

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

The JIP family of MAPK scaffold proteins.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Adaptor functions of Cdc42, Ste50, and Sho1 in the yeast osmoregulatory HOG MAPK pathway.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Osmotic stress and the cytoskeleton: the R(h)ole of Rho GTPases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Rho family Guanine nucleotide exchange factor Brx couples extracellular signals to the glucocorticoid signaling system

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Elevated serum interleukin-18 levels might reflect the high risk of hospitalization in patients on peritoneal dialysis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Intracellular glucocorticoid signaling: a formerly simple system turns stochastic

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Cytokine dysregulation, inflammation and well-being.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Regulation of the osmoregulatory HOG MAPK cascade in yeast

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Hyperosmotic stress induces rapid focal adhesion kinase phosphorylation at tyrosines 397 and 577. Role of Src family kinases and Rho family GTPases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Anchoring of both PKA and 14-3-3 inhibits the Rho-GEF activity of the AKAP-Lbc signaling complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Role of p38alpha Map kinase in Type I interferon signaling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Tissue glucocorticoid resistance/hypersensitivity syndromes.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

The role of NFAT5/TonEBP in establishing an optimal intracellular environment

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Fyn and p38 signaling are both required for maximal hypertonic activation of the osmotic response element-binding protein/tonicity-responsive enhancer-binding protein (OREBP/TonEBP)

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Hyperosmotic stress induces nuclear factor-kappaB activation and interleukin-8 production in human intestinal epithelial cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Osmotic stress signaling and osmoadaptation in yeasts

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

The cytoskeleton and cell volume regulation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Histidine phosphorylation and two-component signaling in eukaryotic cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

The proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathway

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Bridging the NFAT and NF-kappaB families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stress

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Partners in transcription: NFAT and AP-1.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Evolutionary relationships among Rel domains indicate functional diversification by recombination

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Rho signals to cell growth and apoptosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Physical activity and plasma interleukin-6 in humans--effect of intensity of exercise.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Small GTP-binding proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Activation of the Lbc Rho exchange factor proto-oncogene by truncation of an extended C terminus that regulates transformation and targeting

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

p38 kinase activity is essential for osmotic induction of mRNAs for HSP70 and transporter for organic solute betaine in Madin-Darby canine kidney cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Osmoreceptors in the central nervous system

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Regulation of gene expression by hypertonicity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Embryonic estrogen receptors: do they have a physiological function?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Direct involvement of the small GTP-binding protein Rho in lbc oncogene function

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Membrane mechanisms and intracellular signalling in cell volume regulation.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Synovial fluid osmolality in osteoarthritis and rheumatoid arthritis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

The clinical physiology of water metabolism. Part I: The physiologic regulation of arginine vasopressin secretion and thirst

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

COMPOSITION OF THE BLOOD SERUM OF DEEP-SEA FISHES

28 July 2018

1 reference

Intracellular water homeostasis and the mammalian cellular osmotic stress response

21 January 2018

1 reference

Regulation of the hypertonic stress response and other cellular functions by the Rel-like transcription factor NFAT5.

21 January 2018

1 reference

Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice.

21 January 2018

1 reference

Osmotic response element-binding protein (OREBP) is an essential regulator of the urine concentrating mechanism.

21 January 2018

1 reference

Yeast Cdc42 GTPase and Ste20 PAK-like kinase regulate Sho1-dependent activation of the Hog1 MAPK pathway.

21 January 2018

1 reference

Transmembrane mucins Hkr1 and Msb2 are putative osmosensors in the SHO1 branch of yeast HOG pathway.

21 January 2018

1 reference

The Drosophila NFAT homolog is involved in salt stress tolerance

21 January 2018

1 reference

Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

21 January 2018

1 reference

GEFs: structural basis for their activation of small GTP-binding proteins

21 January 2018

1 reference

Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells.

21 January 2018

1 reference

Rho guanine dissociation inhibitors: pivotal molecules in cellular signalling

21 January 2018

1 reference

Interactions among proteins involved in bud-site selection and bud-site assembly in Saccharomyces cerevisiae

21 January 2018

1 reference

AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation

21 January 2018

1 reference

The Rho guanine nucleotide exchange factor AKAP13 (BRX) is essential for cardiac development in mice

21 January 2018

1 reference

Binding of p190RhoGEF to a destabilizing element on the light neurofilament mRNA is competed by BC1 RNA.

21 January 2018

1 reference

Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade

21 January 2018

1 reference

Relationships between the actin cytoskeleton and cell volume regulation

21 January 2018

1 reference

The transcription factor NFAT5 is required for cyclin expression and cell cycle progression in cells exposed to hypertonic stress

21 January 2018

1 reference

Interaction of regulatory T cells with antigen-presenting cells in health and disease

21 January 2018

1 reference

Acute activation of peripheral lymphocytes during treatment of diabetic ketoacidosis

21 January 2018

1 reference

Red blood cell osmotic fragility in chronically hemodialyzed patients.

21 January 2018

1 reference

Acute hypoosmolality attenuates the suppression of cutaneous vasodilation with increased exercise intensity

21 January 2018

1 reference

Plasma hyperosmolality augments peripheral vascular response to baroreceptor unloading during heat stress

21 January 2018

1 reference

Serum osmolality and outcome in intensive care unit patients.

21 January 2018

1 reference

The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation

21 January 2018

1 reference

Vasopressinergic control of pituitary adrenocorticotropin secretion comes of age.

21 January 2018

1 reference

Estrogen effects on the expression of Brx in the brain and pituitary of the mouse.

21 January 2018

1 reference

Effect of fasting on diarrhoea in collagenous colitis.

21 January 2018

1 reference

Glucocorticoid-induced TNF receptor expression by T cells is reciprocally regulated by NF-kappaB and NFAT.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

The osmoprotective function of the NFAT5 transcription factor in T cell development and activation

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

The role of cellular hydration in the regulation of cell function

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964845

Evaluation of a New Tear Osmometer for Repeatability and Accuracy, Using 0.5-μL (500-Nanoliter) Samples

28 October 2018

1 reference

12 December 2020

MEK/ERK signaling controls osmoregulation of nucleus pulposus cells of the intervertebral disc by transactivation of TonEBP/OREBP

1 reference

12 December 2020

Balance between IL-1 beta, TNF-alpha, and their specific inhibitors in chronic renal failure and maintenance dialysis. Relationships with activation markers of T cells, B cells, and monocytes

1 reference

12 December 2020

Osmolarity of Tear Microvolumes in Keratoconjunctivitis Sicca

1 reference

12 December 2020

A combinatorial role for NFAT5 in both myoblast migration and differentiation during skeletal muscle myogenesis

1 reference

12 December 2020

Elevation of pro-inflammatory cytokines, C-reactive protein and cardiac troponin T in chronic renal failure patients on dialysis

1 reference

12 December 2020

Estimates of mouse oviductal fluid tonicity based on osmotic responses of embryos

1 reference

12 December 2020

Organic anions and the diarrhea of inflammatory bowel disease

1 reference

12 December 2020

Interleukin-8 in chronic renal failure and dialysis patients

1 reference

12 December 2020

Hypertonicity-induced phosphorylation and nuclear localization of the transcription factor TonEBP

1 reference

12 December 2020

Identifiers

DOI

10.1586/EEM.10.3

1 reference

31 July 2017

1 reference

31 July 2017

1 reference