(Q34248547)

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Three-dimensional structure of steroid 21-hydroxylase (cytochrome P450 21A2) with two substrates reveals locations of disease-associated variants

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20 January 2020

Three-dimensional structure of steroid 21-hydroxylase (cytochrome P450 21A2) with two substrates reveals locations of disease-associated variants (English)

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20 January 2020

Surajit Banerjee

5

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20 January 2020

F. Peter Guengerich

7

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F Peter Guengerich

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20 January 2020

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Bin Zhao

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20 January 2020

Li Lei

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20 January 2020

Norio Kagawa

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20 January 2020

Munirathinam Sundaramoorthy

4

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20 January 2020

Leslie D Nagy

6

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20 January 2020

Michael R Waterman

8

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20 January 2020

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18 January 2012

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20 January 2020

Journal of Biological Chemistry

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20 January 2020

287

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20 January 2020

13

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20 January 2020

10613-10622

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20 January 2020

Molecular genetics of 21-hydroxylase deficiency

1 reference

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Monitoring of therapy in congenital adrenal hyperplasia

1 reference

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6 July 2018

Molecular diagnosis of congenital adrenal hyperplasia due to 21-hydroxylase deficiency: an update of new CYP21A2 mutations

1 reference

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6 July 2018

21-hydroxylase deficiency congenital adrenal hyperplasia

1 reference

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Features and development of Coot

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Structural basis of human CYP51 inhibition by antifungal azoles

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Crystal Structure of CYP24A1, a Mitochondrial Cytochrome P450 Involved in Vitamin D Metabolism

1 reference

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X-ray structure of human aromatase reveals an androgen-specific active site

1 reference

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6 July 2018

Genetics of congenital adrenal hyperplasia

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6 July 2018

Role of active site water molecules and substrate hydroxyl groups in oxygen activation by cytochrome P450 158A2: a new mechanism of proton transfer

1 reference

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6 July 2018

The use of recombinant methods and molecular engineering in protein crystallization

1 reference

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6 July 2018

PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

1 reference

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6 July 2018

Likelihood-enhanced fast rotation functions

1 reference

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6 July 2018

Functional interaction of cytochrome P450 with its redox partners: a critical assessment and update of the topology of predicted contact regions

1 reference

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6 July 2018

Multiparametric scaling of diffraction intensities

1 reference

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6 July 2018

Congenital adrenal hyperplasia due to 21-hydroxylase deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323056

6 July 2018

Structure of a cytochrome P450-redox partner electron-transfer complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323056

6 July 2018

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

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Detecting and overcoming crystal twinning

1 reference

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6 July 2018

Site-directed mutagenesis of human prostacyclin synthase: Alteration of Cys441 of the Cys-pocket, and Glu347 and Arg350 of the EXXR motif

1 reference

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6 July 2018

Structure of human steroid 21-hydroxylase genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323056

6 July 2018

Two genes encoding steroid 21-hydroxylase are located near the genes encoding the fourth component of complement in man

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323056

6 July 2018

Aberrant splicing and missense mutations cause steroid 21-hydroxylase [P-450(C21)] deficiency in humans: possible gene conversion products

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323056

6 July 2018

Structural analysis of the FMN binding domain of NADPH-cytochrome P-450 oxidoreductase by site-directed mutagenesis

1 reference

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6 July 2018

Evidence that an adrenal-specific nuclear protein regulates the cAMP responsiveness of the human CYP21B (P450C21) gene

1 reference

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6 July 2018

Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.323501

21 January 2018

Congenital adrenal hyperplasia.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.323501

21 January 2018

Molecular model of human CYP21 based on mammalian CYP2C5: structural features correlate with clinical severity of mutations causing congenital adrenal hyperplasia

1 reference

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The cytochrome P450 gene family CYP157 does not contain EXXR in the K-helix reducing the absolute conserved P450 residues to a single cysteine.

1 reference

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21 January 2018

Purification and characterization of bovine steroid 21-hydroxylase (P450c21) efficiently expressed in Escherichia coli.

1 reference

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Structure and function of cytochromes P450: a comparative analysis of three crystal structures.

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1 reference

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21 January 2018

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21 January 2018

A 3D model of human P450c21: study of the putative effects of steroid 21-hydroxylase gene mutations

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cAMP-dependent transcription of the human CYP21B (P-450C21) gene requires a cis-regulatory element distinct from the consensus cAMP-regulatory element

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Population-wide evaluation of disease manifestation in relation to molecular genotype in steroid 21-hydroxylase (CYP21) deficiency: good correlation in a well defined population

1 reference

https://pubmed.ncbi.nlm.nih.gov/22262854

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comprehensive analytical strategy for mutation screening in 21-hydroxylase deficiency

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional characterization of threeCYP21A2sequence variants (p.A265V, p.W302S, p.D322G) employing a yeast co-expression system

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Expression of human cytochrome P450 2B6 in Escherichia coli: characterization of catalytic activity and expression levels in human liver

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.323501

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22262854%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22262854%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22262854%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

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