(Q27658435)

2

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Wen-Xu Hong

3

0 references

Qinghai Zhang

4

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Eric F Johnson

5

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C David Stout

Journal of Molecular Biology

6

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language of work or name

English

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publication date

19 February 2010

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published in

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volume

396

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issue

2

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page(s)

441-51

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cites work

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Structural analysis of CYP2R1 in complex with vitamin D3

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Structure-based design of a superagonist ligand for the vitamin D nuclear receptor

20 March 2017

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Crystal structure of inhibitor-bound P450BM-3 reveals open conformation of substrate access channel

20 March 2017

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Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1alpha,25-(OH)2D3-26,23-lactone

20 March 2017

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Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone

20 March 2017

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A new electron transport mechanism in mitochondrial steroid hydroxylase systems based on structural changes upon the reduction of adrenodoxin

20 March 2017

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Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity

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The tertiary structure of full-length bovine adrenodoxin suggests functional dimers

20 March 2017

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The structure of the cytochrome p450BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid

20 March 2017

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Clustal W and Clustal X version 2.0

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Coot: model-building tools for molecular graphics

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XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density

20 March 2017

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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20 March 2017

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Adrenodoxin: structure, stability, and electron transfer properties

20 March 2017

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Metabolism of vitamin D3 by cytochromes P450

20 March 2017

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An additional electrostatic interaction between adrenodoxin and P450c27 (CYP27A1) results in tighter binding than between adrenodoxin and p450scc (CYP11A1)

20 March 2017

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Automated docking of flexible ligands: applications of AutoDock

20 March 2017

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Mechanisms of cytochrome P450 substrate oxidation: MiniReview

20 March 2017

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Dual metabolic pathway of 25-hydroxyvitamin D3 catalyzed by human CYP24

20 March 2017

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20 March 2017

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TopPred II: an improved software for membrane protein structure predictions

7 April 2017

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Vitamin D and Wnt/beta-catenin pathway in colon cancer: role and regulation of DICKKOPF genes.

7 April 2017

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New paradigm for macromolecular crystallography experiments at SSRL: automated crystal screening and remote data collection

29 September 2017

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Evolution of our understanding of vitamin D.

29 September 2017

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The vitamin D deficiency pandemic and consequences for nonskeletal health: mechanisms of action.

29 September 2017

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Studies of membrane topology of mitochondrial cholesterol hydroxylases CYPs 27A1 and 11A1

29 September 2017

1 reference

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Vitamin D signalling pathways in cancer: potential for anticancer therapeutics

29 September 2017

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Membrane protein insertion: the biology-physics nexus

29 September 2017

1 reference

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Generation of a homology model for the human cytochrome P450, CYP24A1, and the testing of putative substrate binding residues by site-directed mutagenesis and enzyme activity studies

29 September 2017

1 reference

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Self-induced docking site of a deeply embedded peripheral membrane protein

29 September 2017

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Putidaredoxin-to-cytochrome P450cam electron transfer: differences between the two reductive steps required for catalysis

29 September 2017

1 reference

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The ins and outs of cytochrome P450s.

29 September 2017

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Selective inhibitors of vitamin D metabolism--new concepts and perspectives

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

CYP24, the enzyme that catabolizes the antiproliferative agent vitamin D, is increased in lung cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

Promise of vitamin D analogues in the treatment of hyperproliferative conditions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

Structure-function analysis of vitamin D 24-hydroxylase (CYP24A1) by site-directed mutagenesis: amino acid residues responsible for species-based difference of CYP24A1 between humans and rats

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

Cytochromes P450 as versatile biocatalysts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

The role of Vitamin D3 metabolism in prostate cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

Vitamin D and breast cancer: insights from animal models

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

Enzymes involved in the activation and inactivation of vitamin D.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

Structural basis for the role in protein folding of conserved proline-rich regions in cytochromes P450.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

Structural commonalities among integral membrane enzymes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

Hydroxylase enzymes of the vitamin D pathway: expression, function, and regulation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

Highly active analogs of 1alpha,25-dihydroxyvitamin D(3) that resist metabolism through C-24 oxidation and C-3 epimerization pathways

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

Metazoan cytochrome P450 evolution

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

Identifying nonpolar transbilayer helices in amino acid sequences of membrane proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

Automated docking of substrates to proteins by simulated annealing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

Hybrid homology modeling and mutational analysis of cytochrome P450C24A1 (CYP24A1) of the Vitamin D pathway: insights into substrate specificity and membrane bound structure-function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

The 2002 Bernard B. Brodie Award lecture: deciphering substrate recognition by drug-metabolizing cytochromes P450.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

Designing Facial Amphiphiles for the Stabilization of Integral Membrane Proteins

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

Homology model of 1α,25-dihydroxyvitamin D3 24-hydroxylase cytochrome P450 24A1 (CYP24A1): Active site architecture and ligand binding

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

Interaction between mitochondrial CYP27B1 and adrenodoxin: role of arginine 458 of mouse CYP27B1.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

The interaction domain of the redox protein adrenodoxin is mandatory for binding of the electron acceptor CYP11A1, but is not required for binding of the electron donor adrenodoxin reductase.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

Phospholipids modify substrate binding and enzyme activity of human cytochrome P450 27A1.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

Affinity labeling of rat cytochrome P450C24 (CYP24) and identification of Ser57 as an active site residue

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

Rat cytochrome P450C24 (CYP24A1) and the role of F249 in substrate binding and catalytic activity.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

Purification and crystallization of N-terminally truncated forms of microsomal cytochrome P450 2C5.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

Probing the interaction of bovine cytochrome P450scc (CYP11A1) with adrenodoxin: evaluating site-directed mutations by molecular modeling

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830900

Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences

27 November 2018

1 reference

12 December 2020

Monotopic enzymes and lipid bilayers: a comparative study

1 reference

12 December 2020

Self-association of adrenodoxin studied by using analytical ultracentrifugation

1 reference

12 December 2020

Identification of membrane-contacting loops of the catalytic domain of cytochrome P450 2C2 by tryptophan fluorescence scanning

1 reference

12 December 2020

Branched Phosphatidylcholines Stimulate Activity of Cytochrome P450SCC (CYP11A1) in Phospholipid Vesicles by Enhancing Cholesterol Binding, Membrane Incorporation, and Protein Exchange

1 reference

12 December 2020

10.1016/J.JMB.2009.11.057

Identifiers

DOI

1 reference

release_3cqqasfxkjcdbkjvtprsxlz7qe

Fatcat ID

0 references

1 reference

1 reference

PubMed publication ID

19961857

1 reference