(Q46864550)

English

Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.

scientific article published on 21 December 2005

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16373351%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16373351%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

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14 January 2020

author name string

Yonghong Zhao

1

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14 January 2020

B K Muralidhara

3

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14 January 2020

Ling Sun

4

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14 January 2020

James R Halpert

5

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14 January 2020

C David Stout

6

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14 January 2020

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21 December 2005

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14 January 2020

number of pages

9

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Journal of Biological Chemistry

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14 January 2020

281

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14 January 2020

9

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14 January 2020

5973-5981

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14 January 2020

Summary of information on human CYP enzymes: human P450 metabolism data

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Structural diversity of human xenobiotic-metabolizing cytochrome P450 monooxygenases

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An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution

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Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding

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Biochemical studies on cytochrome P-450 solubilized from liver microsomes: partial purification and mechanism of catalysis.

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Analysis of mammalian cytochrome P450 structure and function by site-directed mutagenesis

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Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity

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Structure of mammalian cytochrome P450 2C5 complexed with diclofenac at 2.1 A resolution: evidence for an induced fit model of substrate binding

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Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 A resolution: evidence for multiple substrate binding modes

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Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site

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Crystal structure of human cytochrome P450 2C9 with bound warfarin

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21 January 2018

The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution

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21 January 2018

Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone

1 reference

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21 January 2018

The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution

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21 January 2018

P450 inhibitors of use in medical treatment: focus on mechanisms of action

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Sterol 14 alpha-demethylase, an abundant and essential mixed-function oxidase

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Direct measurement of protein binding energetics by isothermal titration calorimetry

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A truncation of 2B subfamily cytochromes P450 yields increased expression levels, increased solubility, and decreased aggregation while retaining function

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21 January 2018

Processing of X-ray diffraction data collected in oscillation mode

1 reference

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21 January 2018

Integration of macromolecular diffraction data

1 reference

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21 January 2018

The CCP4 suite: programs for protein crystallography

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21 January 2018

Likelihood-enhanced fast rotation functions

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21 January 2018

Likelihood-enhanced fast translation functions

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SOLVE and RESOLVE: automated structure solution and density modification

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Maximum-likelihood density modification

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XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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21 January 2018

PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

1 reference

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21 January 2018

PROCHECK: a program to check the stereochemical quality of protein structures

1 reference

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21 January 2018

Identification of the binding site on cytochrome P450 2B4 for cytochrome b5 and cytochrome P450 reductase.

1 reference

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21 January 2018

Crystallization of cytochromes P450 and substrate-enzyme interactions

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Characterization of the CYP2C8 active site by homology modeling

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Characterization of the CYP3A4 active site by homology modeling

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Structural diversities of active site in clinical azole-bound forms between sterol 14alpha-demethylases (CYP51s) from human and Mycobacterium tuberculosis.

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Determination of the membrane topology of the phenobarbital-inducible rat liver cytochrome P-450 isoenzyme PB-4 using site-specific antibodies

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Single-molecule height measurements on microsomal cytochrome P450 in nanometer-scale phospholipid bilayer disks

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A survey of active site access channels in cytochromes P450.

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Structural commonalities among integral membrane enzymes

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Structural mechanism for sterol sensing and transport by OSBP-related proteins

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The structure of phosphatidylinositol transfer protein alpha reveals sites for phospholipid binding and membrane association with major implications for its function

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The structures of prostaglandin endoperoxide H synthases-1 and -2.

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Cyclooxygenases: structural, cellular, and molecular biology

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Identifiers

10.1074/JBC.M511464200

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16373351%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16373351%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

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