(Q34253805)

31 July 2017

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase (English)

1 reference

31 July 2017

10

Dyann F Wirth

1 reference

31 July 2017

14

Ralph Mazitschek

0 references

Chang-Yeol Yeo

object named as

Chang-Yeol Yeo

13

0 references

Anjana Rao

12

object named as

Anjana Rao

1 reference

31 July 2017

Tracy L Keller

1

1 reference

31 July 2017

Davide Zocco

2

1 reference

31 July 2017

Mark S Sundrud

3

1 reference

31 July 2017

Margaret Hendrick

4

1 reference

31 July 2017

Maja Edenius

5

1 reference

31 July 2017

Jinah Yum

6

1 reference

31 July 2017

Yeon-Jin Kim

7

1 reference

31 July 2017

Hak-Kyo Lee

8

1 reference

31 July 2017

Joseph F Cortese

9

1 reference

31 July 2017

John David Dignam

11

1 reference

31 July 2017

Ralph Mazitschek

14

1 reference

31 July 2017

Malcolm Whitman

15

1 reference

31 July 2017

12 February 2012

1 reference

31 July 2017

Nature Chemical Biology

1 reference

31 July 2017

8

1 reference

31 July 2017

3

1 reference

31 July 2017

311-317

1 reference

https://scigraph.springernature.com/pub.10.1038/nchembio.790

31 July 2017

0 references

cites work

Microarray profiling reveals the integrated stress response is activated by halofuginone in mammary epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Metabolism, migration and memory in cytotoxic T cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

mTOR: from growth signal integration to cancer, diabetes and ageing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Phase II AIDS Malignancy Consortium trial of topical halofuginone in AIDS-related Kaposi sarcoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

The aging stress response

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Control of immune response by amino acid metabolism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Extending healthy life span--from yeast to humans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Dendritic cells, indoleamine 2,3 dioxygenase and acquired immune privilege

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

S100A4 and metastasis: a small actor playing many roles

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Metabolic reprogramming, caloric restriction and aging

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Infectious tolerance via the consumption of essential amino acids and mTOR signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

The GAIT system: a gatekeeper of inflammatory gene expression.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Nutrient sensing and inflammation in metabolic diseases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Specificity of amino acid regulated gene expression: analysis of genes subjected to either complete or single amino acid deprivation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Xenohormesis: sensing the chemical cues of other species

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Rapid, transcript-specific changes in splicing in response to environmental stress

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Regulation of immune responses by L-arginine metabolism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Nutritional control of gene expression: how mammalian cells respond to amino acid limitation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Lessons from natural molecules

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Halofuginone to treat fibrosis in chronic graft-versus-host disease and scleroderma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Potent antimalarial febrifugine analogues against the plasmodium malaria parasite.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Catalytic Asymmetric Synthesis of Antimalarial Alkaloids Febrifugine and Isofebrifugine and Their Biological Activity.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

A succession of substrate induced conformational changes ensures the amino acid specificity of Thermus thermophilus prolyl-tRNA synthetase: comparison with histidyl-tRNA synthetase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Regulated translation initiation controls stress-induced gene expression in mammalian cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

6 July 2018

Aminoacyl-tRNA synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Halofuginone: a novel antifibrotic therapy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Chemotherapy of Chicken Coccidiosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Mono Q chromatography permits recycling of DNA template and purification of RNA transcripts after T7 RNA polymerase reaction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Effect of halofuginone on the development of tight skin (TSK) syndrome

6 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.790

Rapamycin inhibits relapsing experimental autoimmune encephalomyelitis by both effector and regulatory T cells modulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.790

The bacterial YbaK protein is a Cys-tRNAPro and Cys-tRNA Cys deacylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.790

Transfer RNA modulates the editing mechanism used by class II prolyl-tRNA synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.790

Metastasis-inducing S100A4 protein is associated with the disease activity of rheumatoid arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.790

A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition among threonyl-tRNA synthetases

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Studies in human malaria. XXV. Trial of febrifugine, an alkaloid obtained from Dichroa febrifuga lour., against the Chesson strain of Plasmodium vivax

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281520

Indoleamine 2,3-dioxygenase–expressing myeloid dendritic cells and macrophages in infectious and noninfectious cutaneous granulomas

28 October 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.790

IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.790

Inhibition of bladder carcinoma angiogenesis, stromal support, and tumor growth by halofuginone

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22327401

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22327401

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Isolation of prolyl-tRNA synthetase as a free form and as a form associated with glutamyl-tRNA synthetase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22327401

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.790

1 reference

31 July 2017

1 reference

31 July 2017

1 reference