(Q34257881)

English

Amifostine: an update on its clinical status as a cytoprotectant in patients with cancer receiving chemotherapy or radiotherapy and its potential therapeutic application in myelodysplastic syndrome

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

1 reference

Europe PubMed Central

Amifostine: an update on its clinical status as a cytoprotectant in patients with cancer receiving chemotherapy or radiotherapy and its potential therapeutic application in myelodysplastic syndrome (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Adaptive radiation therapy

0 references

1 reference

based on heuristic

inferred from title

author name string

C R Culy

1

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

C M Spencer

2

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

publication date

1 January 2001

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

61

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

641-684

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

https://scigraph.springernature.com/pub.10.2165/00003495-200161050-00012

0 references

Radioprotection of mouse skin vasculature and the RIF-1 fibrosarcoma by WR-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of amifostine: effects of dose and method of administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection by WR-2721 against radiation plus cis-diamminedichloroplatinum II caused injury to colonic epithelium in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine--a radioprotector in locally advanced head and neck tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modification of WR-2721 radiation protection from gastrointestinal injury and death in mice by 2-mercaptopropionylglycine

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine cytoprotection with chemotherapy for advanced ovarian carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of WR 2721 on radiation response of canine soft tissue sarcomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase I trial of amifostine (WR-2721) and melphalan in children with refractory cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurologic protection by amifostine

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of tumours with the combination of WR-2721 and cis-dichlorodiammineplatinum (II) or cyclophosphamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioprotection of two mouse tumors by WR-2721 in single and fractionated treatments

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A risk-benefit assessment of amifostine in cytoprotection

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection against cis-diamminedichloroplatinum cytotoxicity and mutagenicity in V79 cells by 2-[(aminopropyl)amino]ethanethiol

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection and potentiation of nitrogen mustard cytotoxicity by WR-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uptake of WR-2721 derivatives by cells in culture: identification of the transported form of the drug

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypocalcemia and Inhibition of Parathyroid Hormone Secretion after Administration of WR-2721 (a Radioprotective and Chemoprotective Agent)

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human pharmacokinetics of WR-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pilot trial of cytoprotection with amifostine given with high-dose chemotherapy and autologous peripheral blood stem cell transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential as a radioprotector and cytotoxic chemoprotector

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine pretreatment for protection against cyclophosphamide-induced and cisplatin-induced toxicities: results of a randomized control trial in patients with advanced ovarian cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modification of the radiation response of the mouse kidney by misonidazole and WR-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of cycloheximide and WR-1065 on radiation-induced repair processes: a mechanism for chemoprevention

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2-[(Aminopropyl)amino]ethanethiol (WR1065) is anti-neoplastic and anti-mutagenic when given during 60Co gamma-ray irradiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topical application of WR-2721 to prevent radiation-induced proctosigmoiditis. A phase I/II trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of carboplatin with and without amifostine in patients with solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomized study of a short course of weekly cisplatin with or without amifostine in advanced head and neck cancer. EORTC Head and Neck Cooperative Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo amifostine (WR-2721) prevents chemotherapy-induced apoptosis of peripheral blood lymphocytes from cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Repression of c-myc gene expression by the thiol and disulfide forms of the cytoprotector amifostine

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WR2721 as a modulator of cisplatin- and carboplatin-induced side effects in comparison with other chemoprotective agents: a molecular approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-(2-mercaptoethyl)-1,3-propanediamine (WR-1065) protects thymocytes from programmed cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxygen-dependent protection of radiation lung damage in mice by WR 2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of the radioprotector WR 2721 on the response of metastatic Lewis lung carcinoma colonies to alkylating agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A randomized trial of amifostine as a cytoprotective agent in patients receiving chemotherapy for small cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine improves the antileukemic therapeutic index of mafosfamide: implications for bone marrow purging

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I Controlled trials of WR-2721 and cyclophosphamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Future directions in non-small cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purging of small cell lung cancer cells from human bone marrow using ethiofos (WR-2721) and light-activated merocyanine 540 phototreatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of tumor size on S-2-(3-aminopropylamino)ethylphosphorothioic acid and misonidazole alteration of tumor response to cyclophosphamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-dose therapy with combined 5-fluorouracil and folinic acid with and without amifostine in the treatment of patients with metastatic colorectal carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Salivary gland protection by amifostine in high-dose radioiodine treatment: results of a double-blind placebo-controlled study

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NCCN practice guidelines for the myelodysplastic syndromes. National Comprehensive Cancer Network

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioprotection of salivary glands by S-2-(3-aminopropylamino)-ethylphosphorothioic (amifostine) obtained in a rabbit animal model

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential protection against cytotoxic chemotherapeutic effects on bone marrow CFUs by Wr-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine inhibits hematopoietic progenitor cell apoptosis by activating NF-kappaB/Rel transcription factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The reversal of cisplatin-protein interactions by the modulating agent WR2721 and its metabolites WR1065 and WR33278

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A randomized trial of amifostine in patients with high-dose VIC chemotherapy plus autologous blood stem cell transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Granulocyte colony-stimulating factor and amifostine (Ethyol) synergize to enhance hemopoietic reconstitution and increase survival in irradiated animals

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of radioprotective thiols and disulfides in Chinese hamster V79 cell nuclei.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of WR2721 on DNA cross-linking by nitrogen mustard in normal mouse bone marrow and leukemia cells in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Short-Term Radioprotective Effects of WR-2721 on the Rat Parotid Glands

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Poor response rate to a continuous schedule of Amifostine therapy for 'low/intermediate risk' myelodysplastic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effect of S-2-(3-aminopropylamino)ethylphosphorothioic acid against induction of altered hepatocyte foci in rats treated once with gamma-radiation within one day after birth

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modification of radiation-induced carcinogenesis in mice by misonidazole and WR-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine protects primitive hematopoietic progenitors against chemotherapy cytotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The radioprotector WR-2721 reduces neutron-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in mouse splenocytes when administered prior to or following irradiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of hematopoiesis by amifostine in patients with myelodysplastic syndrome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine cytotoxicity and induction of apoptosis in a human myelodysplastic cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antimutagenic effects of radioprotector WR-2721 against fission-spectrum neurons and 60Co gamma-rays in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine modulation of bleomycin-induced lung injury in rodents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct amifostine effect on renal tubule cells in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of radiation carcinogenesis in mice by S-2-(3-aminopropylamino)-ethylphosphorothioic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of the administration of amifostine on the pharmacokinetics of 5-fluorouracil in patients with metastatic colorectal carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carboplatin and paclitaxel in non-small cell lung cancer: the role of amifostine

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bone marrow protection with amifostine in the treatment of high-risk malignant lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the protective effects of three phosphorothioate radioprotectors in the RIF-1 tumor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time dependence of the selective modulation of cisplatin-induced nephrotoxicity by WR2721 in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase III randomized trial of amifostine as a radioprotector in head and neck cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Postirradiation treatment with granulocyte colony-stimulating factor and preirradiation WR-2721 administration synergize to enhance hemopoietic reconstitution and increase survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of WR-2721.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection of acute and late radiation damage of the gastrointestinal tract by WR-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical practice guidelines for the treatment of unresectable non-small-cell lung cancer. Adopted on May 16, 1997 by the American Society of Clinical Oncology

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo protection by the aminothiol WR-2721 against neutron-induced carcinogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine: mechanisms of action underlying cytoprotection and chemoprevention

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Future directions in gynecologic cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of tumor type, size, and endpoint on tumor radioprotection by WR-2721.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine pretreatment for protection against topotecan-induced hematologic toxicity: results of a multicenter phase III trial in patients with advanced gynecologic malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the modulating agent WR2721 on myelotoxicity and antitumour activity in carboplatin-treated mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of treatment with amifostine used as a single agent in patients with refractory anemia on clinical outcome and serum tumor necrosis factor α levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical evaluation of WR-151327: an orally active chemotherapy protector

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of amifostine in bone marrow purging

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of radiation with or without WR-2721 in advanced rectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of reduced doses of amifostine to ameliorate nephrotoxicity of cisplatin/ifosfamide-based chemotherapy in patients with solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioprotection of the rat small intestine with topical WR-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radiochemotherapy with amifostine cytoprotection for head and neck cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformational changes in chromatin structure induced by the radioprotective aminothiol, WR 1065

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WR-2721 protects against the hematologic toxicity of cyclophosphamide: a controlled phase II trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of amifostine on perfused isolated rat heart and on acute doxorubicin-induced cardiotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

American Society of Clinical Oncology clinical practice guidelines for the use of chemotherapy and radiotherapy protectants

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ex vivo manipulation of hematopoietic stem cells for transplantation: the potential role of amifostine

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modification of cyclophosphamide-induced pulmonary toxicity in normal mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine (WR-2721) shortens the engraftment period of 4-hydroperoxycyclophosphamide-purged bone marrow in breast cancer patients receiving high-dose chemotherapy with autologous bone marrow support

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection against late effects of radiation by S-2-(3-aminopropylamino)-ethylphosphorothioic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioprotection by WR-2721 against Long-Term Chronic Damage to the Rat Parotid Gland

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic profile of amifostine

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomized trial of carboplatin plus amifostine versus carboplatin alone in patients with advanced solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of uroprotective efficacy of amifostine against cyclophosphamide induced hemorrhagic cystitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of amifostine on the pharmacokinetics of cisplatin in cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine, cisplatin, and vinblastine in metastatic non-small-cell lung cancer: a report of high response rates and prolonged survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Patients with myelodysplastic syndromes benefit from palliative therapy with amifostine, pentoxifylline, and ciprofloxacin with or without dexamethasone

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of amifostine and its metabolites in patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The preclinical basis for broad-spectrum selective cytoprotection of normal tissues from cytotoxic therapies by amifostine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A pilot study to evaluate the feasibility of using willingness to pay as a measure of value in cancer supportive care: an assessment of amifostine cytoprotection

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of WR-1065 in mouse tissue following treatment with WR-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Daily amifostine given concomitantly to chemoradiation in head and neck cancer. A pilot study

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardioprotection of rat heart myocytes with amifostine (Ethyol) and its free thiol, WR-1065, in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advanced epithelial ovarian cancer: 1998 consensus statements

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effect of amifostine on dental health after radiotherapy of the head and neck

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine protects normal tissues from paclitaxel toxicity while cytotoxicity against tumour cells is maintained

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subcutaneous administration of amifostine during fractionated radiotherapy: a randomized phase II study

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomized clinical trial of mitomycin-C with or without pretreatment with WR-2721 in patients with advanced colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioprotection by WR-2721 of gamma-irradiated rat parotid gland: effect on gland weight and secretion at 8-10 days post irradiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine (WR-2721) Protects Normal Haematopoietic Stem Cells Against Cyclophosphamide Derivatives' Toxicity Without Compromising Their Antileukaemic Effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the modulating agent WR2721 and its main metabolites on the formation and stability of cisplatin-DNA adducts in vitro in comparison to the effects of thiosulphate and diethyldithiocarbamate

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential protection of normal and malignant tissues against the cytotoxic effects of mechlorethamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine as protective agent in cisplatin-based chemotherapy of advanced bladder cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carboplatin combined with amifostine, a bone marrow protectant, in the treatment of non-small-cell lung cancer: a randomised phase II study

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct evaluation of radiation damage in human hematopoietic progenitor cells in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine reduces the incidence of cumulative nephrotoxicity from cisplatin: laboratory and clinical aspects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cisplatin neuropathy. Risk factors, prognosis, and protection by WR-2721.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through a p53-dependent pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoprotection by WR-1065, the active form of amifostine, is independent of p53 status in human malignant glioma cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine can reduce mucosal damage after high-dose melphalan conditioning for peripheral blood progenitor cellautotransplant: a retrospective study

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antimutagenic effects of amifostine: clinical implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A randomized study of very accelerated radiotherapy with and without amifostine in head and neck squamous cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro effect of amifostine on haematopoietic progenitors exposed to carboplatin and non-alkylating antineoplastic drugs: haematoprotection acts as a drug-specific progenitor rescue

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of thymidine kinase messenger RNA and a related transcript is modulated by radioprotector WR1065

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effects of 2-[(aminopropyl)amino] ethanethiol against bleomycin and nitrogen mustard-induced mutagenicity in V79 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Properties of wr2721 (ethiofos) as modulator of Cisplatin-induced neurotoxicity studied at the ultrastructural level in the pond snail lymnaea-stagnalis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective inhibition of the nephrotoxicity of cis-dichlorodiammineplatinum(II) by WR-2721 without altering its antitumor properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine in the treatment of low-risk myelodysplastic syndromes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine (WR-2721), a cytoprotective agent during high-dose cyclophosphamide treatment of non-Hodgkin's lymphomas: a phase II study

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracolonic WR 2721 protection of the rat colon from acute radiation injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thiol WR-1065 and disulphide WR-33278, two metabolites of the drug ethyol (WR-2721), protect DNA against fast neutron-induced strand breakage

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Management of hypocalcemic effects of WR2721 administered on a daily times five schedule with cisplatin and radiation therapy. The New York Gynecologic Oncology Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The modification of melphalan toxicity in tumor bearing mice by S-2-(3-aminopropylamino)-ethylphosphorothioic acid (WR2721)

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection of mouse lung by WR-2721 after fractionated doses of irradiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomized phase II study of high-dose paclitaxel with or without amifostine in patients with metastatic breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Final report of the phase I trial of single-dose WR-2721 [S-2-(3-aminopropylamino)ethylphosphorothioic acid]

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro protection from cisplatin-induced neurotoxicity by amifostine and its metabolite WR1065.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of WR-2721 on the toxicity and antitumor activity of the combination of carboplatin and 5-fluorouracil

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection by amifostine of cyclophosphamide-induced myelosuppression

1 reference

https://pubmed.ncbi.nlm.nih.gov/11368288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2165/00003495-200161050-00012

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

ResearchGate publication ID

0 references

Sitelinks

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