(Q34273067)

1 August 2017

title

Engineering synthetic recursive pathways to generate non-natural small molecules (English)

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1 August 2017

4

Kendall N Houk

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1 August 2017

Elizabeth A Felnagle

1

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1 August 2017

Asha Chaubey

series ordinal

2

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1 August 2017

Elizabeth L Noey

series ordinal

3

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1 August 2017

James C Liao

series ordinal

5

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1 August 2017

publication date

17 May 2012

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1 August 2017

published in

Nature Chemical Biology

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1 August 2017

volume

8

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1 August 2017

issue

6

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1 August 2017

page(s)

518-526

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https://scigraph.springernature.com/pub.10.1038/nchembio.959

1 August 2017

exact match

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cites work

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Biosynthesis and engineering of isoprenoid small molecules

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Nonribosomal peptide synthetases involved in the production of medically relevant natural products

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Stereospecific living radical polymerization: dual control of chain length and tacticity for precision polymer synthesis

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Nucleobase-templated polymerization: copying the chain length and polydispersity of living polymers into conjugated polymers

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Organocatalytic cascade reactions as a new tool in total synthesis

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Total synthesis of marine natural products without using protecting groups

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Metabolic engineering of fatty acid biosynthesis in plants.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Tailoring plant lipid composition: designer oilseeds come of age.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Engineering of bacterial methyl ketone synthesis for biofuels

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Microbial production of fatty-acid-derived fuels and chemicals from plant biomass

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Engineered reversal of the β-oxidation cycle for the synthesis of fuels and chemicals

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Engineering of an "unnatural" natural product by swapping polyketide synthase domains in Aspergillus nidulans

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.

21 January 2018

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Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Production of hybrid 16-membered macrolides by expressing combinations of polyketide synthase genes in engineered Streptomyces fradiae hosts

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Mutasynthesis - uniting chemistry and genetics for drug discovery

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Mechanism and engineering of polyketide chain initiation in fredericamycin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

An aldol switch discovered in stilbene synthases mediates cyclization specificity of type III polyketide synthases

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

New insights into the formation of fungal aromatic polyketides

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Redirecting the cyclization steps of fungal polyketide synthase.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Production of the antimalarial drug precursor artemisinic acid in engineered yeast

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Unearthing the roots of the terpenome

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Chimeras of two isoprenoid synthases catalyze all four coupling reactions in isoprenoid biosynthesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Engineering cotton (+)-delta-cadinene synthase to an altered function: germacrene D-4-ol synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Identifying and manipulating structural determinates linking catalytic specificities in terpene synthases

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Expanding metabolism for biosynthesis of nonnatural alcohols

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Metabolic engineering of Escherichia coli for 1-butanol and 1-propanol production via the keto-acid pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Transcriptomic and reverse genetic analyses of branched-chain fatty acid and acyl sugar production in Solanum pennellii and Nicotiana benthamiana.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Biosynthesis of methionine-derived glucosinolates in Arabidopsis thaliana: recombinant expression and characterization of methylthioalkylmalate synthase, the condensing enzyme of the chain-elongation cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

MAM3 catalyzes the formation of all aliphatic glucosinolate chain lengths in Arabidopsis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Biosynthesis of glucosinolates--gene discovery and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Genetic control of natural variation in Arabidopsis glucosinolate accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Biology and biochemistry of glucosinolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

From amino acid to glucosinolate biosynthesis: protein sequence changes in the evolution of methylthioalkylmalate synthase in Arabidopsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Alpha-keto acid chain elongation reactions involved in the biosynthesis of coenzyme B (7-mercaptoheptanoyl threonine phosphate) in methanogenic Archaea

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Methanogen homoaconitase catalyzes both hydrolyase reactions in coenzyme B biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Positive selection driving diversification in plant secondary metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Two Arabidopsis genes (IPMS1 and IPMS2) encode isopropylmalate synthase, the branchpoint step in the biosynthesis of leucine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Crystal structure of LeuA from Mycobacterium tuberculosis, a key enzyme in leucine biosynthesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

MODBASE, a database of annotated comparative protein structure models and associated resources.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Metabolic engineering for the production of natural products.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Loss of co-linearity by modular polyketide synthases: a mechanism for the evolution of chemical diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Cation induced differential effect on structural and functional properties of Mycobacterium tuberculosis alpha-isopropylmalate synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Mapping the limits of substrate specificity of the adenylation domain of TycA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Directed enzyme evolution: climbing fitness peaks one amino acid at a time

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

The chalcone synthase superfamily of type III polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Overproduction of free fatty acids in E. coli: implications for biodiesel production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Improving cellular malonyl-CoA level in Escherichia coli via metabolic engineering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

A process for microbial hydrocarbon synthesis: Overproduction of fatty acids in Escherichia coli and catalytic conversion to alkanes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Engineering central metabolic pathways for high-level flavonoid production in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

The effects of feed and intracellular pyruvate levels on the redistribution of metabolic fluxes in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Harnessing the potential of communication-mediating domains for the biocombinatorial synthesis of nonribosomal peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Polyketide and non-ribosomal peptide synthases: falling together by coming apart

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

The origins of specificity in polyketide synthase protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Covalent linkage mediates communication between ACP and TE domains in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Synthetic protein scaffolds provide modular control over metabolic flux.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Polyhedral organelles compartmenting bacterial metabolic processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Structure and mechanisms of a protein-based organelle in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Synthesis of empty bacterial microcompartments, directed organelle protein incorporation, and evidence of filament-associated organelle movement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Modularity of a carbon-fixing protein organelle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Short N-terminal sequences package proteins into bacterial microcompartments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

A thioesterase from an iterative fungal polyketide synthase shows macrocyclization and cross coupling activity and may play a role in controlling iterative cycling through product offloading

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Chain-length determination mechanism of isoprenyl diphosphate synthases and implications for molecular evolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Phenotype sequencing: identifying the genes that cause a phenotype directly from pooled sequencing of independent mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

C-C bond formation and cleavage in radical enzymes, a theoretical perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Evaluation and ranking of enzyme designs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

A novel method for enzyme design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Kemp elimination catalysts by computational enzyme design

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Design of a Novel Globular Protein Fold with Atomic-Level Accuracy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

De novo computational design of retro-aldol enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Computational design of receptor and sensor proteins with novel functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Theozymes and compuzymes: theoretical models for biological catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Advances in quantum and molecular mechanical (QM/MM) simulations for organic and enzymatic reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Catalytic Chain Transfer in Free-Radical Polymerizations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Nature of Forces between Large Molecules of Biological Interest*

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.959

Different elongation pathways in the biosynthesis of acyl groups of trichome exudate sugar esters from various solanaceous plants

21 January 2018

1 reference

12 December 2020

Changes in the intracellular concentration of acetyl-CoA and malonyl-CoA in relation to the carbon and energy metabolism of Escherichia coli K12.

1 reference

12 December 2020

A synthetic recursive "+1" pathway for carbon chain elongation

1 reference

12 December 2020

Expression of a Brassica isopropylmalate synthase gene in Arabidopsis perturbs both glucosinolate and amino acid metabolism

1 reference

12 December 2020

Optimization of a heterologous pathway for the production of flavonoids from glucose

1 reference

12 December 2020

Modular Pathway Engineering of Diterpenoid Synthases and the Mevalonic Acid Pathway for Miltiradiene Production

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.959

1 reference

Dimensions Publication ID

1 August 2017

1012598705

0 references

Fatcat ID

release_7rsgbao5bfdsthegnrkvj74664

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/7rsgbao5bfdsthegnrkvj74664

24 November 2022

mapped directly with Wikidata item

1 reference