(Q34274190)

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Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions

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scholarly article

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Europe PubMed Central

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1 August 2017

Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions (English)

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Europe PubMed Central

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1 August 2017

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Jason A. Roberts

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1 June 2020

Mohd-Hafiz Abdul-Aziz

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1 June 2020

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Johan W Mouton

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George L. Drusano

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George Drusano

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Alexander A Vinks

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Andras Farkas

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Michael N Neely

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Jerome J Schentag

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Otto R Frey

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Ursula Theuretzbacher

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Joseph L Kuti

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1 June 2020

International Society of Anti-Infective Pharmacology and the Pharmacokinetics and Pharmacodynamics Study Group of the European Society of Clinical Microbiology and Infectious Diseases

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1 June 2020

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24 April 2014

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12

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Lancet Infectious Diseases

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1 June 2020

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1 June 2020

498-509

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1 June 2020

Protein binding of β-lactam antibiotics in critically ill patients: can we successfully predict unbound concentrations?

1 reference

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Monte Carlo simulations based on phase 1 studies predict target attainment of ceftobiprole in nosocomial pneumonia patients: a validation study

1 reference

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Software for dosage individualization of voriconazole for immunocompromised patients

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Prolonged infusion antibiotics for suspected gram-negative infections in the ICU: a before-after study

1 reference

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Benchmarking therapeutic drug monitoring software: a review of available computer tools

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Dosing nomograms for attaining optimum concentrations of meropenem by continuous infusion in critically ill patients with severe gram-negative infections: a pharmacokinetics/pharmacodynamics-based approach

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Does Beta-lactam Pharmacokinetic Variability in Critically Ill Patients Justify Therapeutic Drug Monitoring? A Systematic Review

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Improving antibiotic dosing in special situations in the ICU: burns, renal replacement therapy and extracorporeal membrane oxygenation

1 reference

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DALI: Defining Antibiotic Levels in Intensive care unit patients: a multi-centre point of prevalence study to determine whether contemporary antibiotic dosing for critically ill patients is therapeutic

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Pharmacological and patient-specific response determinants in patients with hospital-acquired pneumonia treated with tigecycline

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Pharmacokinetics-pharmacodynamics of tigecycline in patients with community-acquired pneumonia

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Antibiotics in critically ill patients: a systematic review of the pharmacokinetics of β-lactams

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Penetration of anti-infective agents into pulmonary epithelial lining fluid: focus on antibacterial agents

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Therapeutic drug monitoring of antimicrobials

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Further increases in carbapenem-, amikacin-, and fluoroquinolone-resistant isolates of Acinetobacter spp. and P. aeruginosa in Korea: KONSAR study 2009

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Pharmacokinetics of ciprofloxacin and its penetration into bronchial secretions of mechanically ventilated patients with chronic obstructive pulmonary disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

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Recommended β-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

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Antibiotic dosing in multiple organ dysfunction syndrome

1 reference

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Vancomycin dosing in critically ill patients: robust methods for improved continuous-infusion regimens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

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Penetration of meropenem into epithelial lining fluid of patients with ventilator-associated pneumonia

1 reference

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The effects of hypoalbuminaemia on optimizing antibacterial dosing in critically ill patients

1 reference

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Optimization of meropenem dosage in the critically ill population based on renal function

1 reference

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Monte Carlo simulations: maximizing antibiotic pharmacokinetic data to optimize clinical practice for critically ill patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

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Therapeutic drug monitoring of linezolid: a retrospective monocentric analysis.

1 reference

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fAUC/MIC is the most predictive pharmacokinetic/pharmacodynamic index of colistin against Acinetobacter baumannii in murine thigh and lung infection models.

1 reference

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Pharmacokinetic-pharmacodynamic-model-guided doripenem dosing in critically ill patients

1 reference

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Clinical pharmacodynamics of cefepime in patients infected with Pseudomonas aeruginosa

1 reference

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Empirical models for dosage optimization of four beta-lactams in critically ill septic patients based on therapeutic drug monitoring of amikacin

1 reference

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Elucidation of the pharmacokinetic/pharmacodynamic determinant of colistin activity against Pseudomonas aeruginosa in murine thigh and lung infection models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

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Intensity of continuous renal-replacement therapy in critically ill patients

1 reference

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Vancomycin therapeutic guidelines: a summary of consensus recommendations from the infectious diseases Society of America, the American Society of Health-System Pharmacists, and the Society of Infectious Diseases Pharmacists

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Principles of antibacterial dosing in continuous renal replacement therapy

1 reference

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A systematic review on clinical benefits of continuous administration of beta-lactam antibiotics

1 reference

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1 reference

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Prospectively validated dosing nomograms for maximizing the pharmacodynamics of vancomycin administered by continuous infusion in critically ill patients

1 reference

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1 reference

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1 reference

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Exposure-response analyses of tigecycline efficacy in patients with complicated intra-abdominal infections

1 reference

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Back to the future: using aminoglycosides again and how to dose them optimally

1 reference

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Clinical pharmacodynamics of meropenem in patients with lower respiratory tract infections

1 reference

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Impact of sample size on the performance of multiple-model pharmacokinetic simulations

1 reference

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Pharmacokinetics of unbound linezolid in plasma and tissue interstitium of critically ill patients after multiple dosing using microdialysis

1 reference

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Optimization of meropenem minimum concentration/MIC ratio to suppress in vitro resistance of Pseudomonas aeruginosa

1 reference

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Continuous versus intermittent intravenous administration of antibiotics: a meta-analysis of randomised controlled trials

1 reference

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1 reference

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The pharmacokinetic and pharmacodynamic profile of tigecycline

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When "S" does not mean success: the importance of choice of antibiotic and dose on clinical and economic outcomes of severe infection

1 reference

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Pharmacodynamic evaluation of extending the administration time of meropenem using a Monte Carlo simulation

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In vivo pharmacodynamic activity of daptomycin

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Vital organ blood flow during hyperdynamic sepsis

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Selection of resistant Streptococcus pneumoniae during penicillin treatment in vitro and in three animal models

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Pharmacodynamics of cefepime in patients with Gram-negative infections

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Immunotherapy of sepsis

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In vivo pharmacodynamic activities of two glycylcyclines (GAR-936 and WAY 152,288) against various gram-positive and gram-negative bacteria

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Use of pharmacodynamic indices to predict efficacy of combination therapy in vivo.

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Optimizing aminoglycoside therapy for nosocomial pneumonia caused by gram-negative bacteria

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Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients

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Validation of the Hartford nomogram in trauma surgery patients.

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Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men.

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Pharmacodynamics of levofloxacin: a new paradigm for early clinical trials

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Is continuous infusion of beta-lactam antibiotics worthwhile?--efficacy and pharmacokinetic considerations

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Pharmacokinetics and pharmacodynamics of antibiotics in otitis media

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A meta-analysis of studies on the safety and efficacy of aminoglycosides given either once daily or as divided doses

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Pharmacodynamics of intravenous ciprofloxacin in seriously ill patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

6 July 2018

Pharmacokinetics of antibiotics in natural and experimental superficial compartments in animals and humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

6 July 2018

Predictive performance of two software packages (USC*PACK PC and Abbott PKS system) for the individualization of amikacin dosage in intensive care unit patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

6 July 2018

Clinical response to aminoglycoside therapy: importance of the ratio of peak concentration to minimal inhibitory concentration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

6 July 2018

Correlation of antimicrobial pharmacokinetic parameters with therapeutic efficacy in an animal model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

6 July 2018

Evaluation of intravenous ciprofloxacin in patients with nosocomial lower respiratory tract infections. Impact of plasma concentrations, organism, minimum inhibitory concentration, and clinical condition on bacterial eradication.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

6 July 2018

A prospective randomized study comparing once- versus twice-daily amikacin dosing in critically ill adult and paediatric patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

6 July 2018

Vancomycin pharmacodynamics and survival in patients with methicillin-resistant Staphylococcus aureus-associated septic shock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Optimal doripenem dosing simulations in critically ill nosocomial pneumonia patients with obesity, augmented renal clearance, and decreased bacterial susceptibility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

The clinical relevance of plasma protein binding changes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Efficacy of high-dose nebulized colistin in ventilator-associated pneumonia caused by multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Continuous infusion of beta-lactam antibiotics in severe sepsis: a multicenter double-blind, randomized controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Drotrecogin alfa (activated) in adults with septic shock.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: a multicentre pharmacokinetic study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Therapeutic drug monitoring of beta-lactams in critically ill patients: proof of concept

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Support for higher ciprofloxacin AUC 24/MIC targets in treating Enterobacteriaceae bloodstream infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Flucloxacillin dosing in critically ill patients with hypoalbuminaemia: special emphasis on unbound pharmacokinetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

First-dose and steady-state population pharmacokinetics and pharmacodynamics of piperacillin by continuous or intermittent dosing in critically ill patients with sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

International study of the prevalence and outcomes of infection in intensive care units

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Intensive versus conventional glucose control in critically ill patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Piperacillin penetration into tissue of critically ill patients with sepsis--bolus versus continuous administration?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Feedback dose alteration significantly affects probability of pathogen eradication in nosocomial pneumonia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Population pharmacokinetics of high-dose, prolonged-infusion cefepime in adult critically ill patients with ventilator-associated pneumonia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Glomerular hyperfiltration and albuminuria in critically ill patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Trends in antimicrobial susceptibility of Gram-negative isolates from a paediatric intensive care unit in Warsaw: results from the MYSTIC programme (1997-2007).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Alveolar concentrations of piperacillin/tazobactam administered in continuous infusion to patients with ventilator-associated pneumonia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Evaluation of area under the inhibitory curve (AUIC) and time above the minimum inhibitory concentration (T>MIC) as predictors of outcome for cefepime and ceftazidime in serious bacterial infections

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Ertapenem in critically ill patients with early-onset ventilator-associated pneumonia: pharmacokinetics with special consideration of free-drug concentration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Comparison of unit-specific and hospital-wide antibiograms: potential implications for selection of empirical antimicrobial therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Antimicrobial susceptibility pattern comparisons among intensive care unit and general ward Gram-negative isolates from the Meropenem Yearly Susceptibility Test Information Collection Program (USA).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Selection of ciprofloxacin resistance in Escherichia coli in an in vitro kinetic model: relation between drug exposure and mutant prevention concentration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Pneumonia caused by oxacillin-resistant Staphylococcus aureus treated with glycopeptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Comparison of beta-lactams in counter-selecting resistance of Pseudomonas aeruginosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Pharmacodynamics of tobramycin in patients with cystic fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Fluid shifts have no influence on ciprofloxacin pharmacokinetics in intensive care patients with intra-abdominal sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Relationship between fluoroquinolone area under the curve: minimum inhibitory concentration ratio and the probability of eradication of the infecting pathogen, in patients with nosocomial pneumonia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Steady-state plasma and intrapulmonary concentrations of piperacillin/tazobactam 4 g/0.5 g administered to critically ill patients with severe nosocomial pneumonia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Plasma and lung concentrations of ceftazidime administered in continuous infusion to critically ill patients with severe nosocomial pneumonia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Clinical pharmacodynamics of linezolid in seriously ill patients treated in a compassionate use programme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Cefepime versus cefpirome: the importance of creatinine clearance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Steady-state plasma and intrapulmonary concentrations of cefepime administered in continuous infusion in critically ill patients with severe nosocomial pneumonia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Treatment and outcome of Pseudomonas aeruginosa bacteraemia: an antibiotic pharmacodynamic analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Pharmacodynamic profile of daptomycin against Enterococcus species and methicillin-resistant Staphylococcus aureus in a murine thigh infection model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Target site penetration of fosfomycin in critically ill patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Teicoplanin therapeutic drug monitoring in critically ill patients: a retrospective study emphasizing the importance of a loading dose

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Continuous versus intermittent administration of ceftazidime in intensive care unit patients with nosocomial pneumonia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

The pharmacokinetics of once-daily dosing of ceftriaxone in critically ill patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Impaired target site penetration of beta-lactams may account for therapeutic failure in patients with septic shock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Design of dosage regimens: a multiple model stochastic control approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

DALI: Defining Antibiotic Levels in Intensive Care Unit Patients: Are Current -Lactam Antibiotic Doses Sufficient for Critically Ill Patients?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Antimicrobial Resistance: Pharmacokinetics‐Pharmacodynamics of Antimicrobial Therapy: It’s Not Just for Mice Anymore

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181663

28 October 2018

Do we understand the impact of altered physiology, consequent interventions and resultant clinical scenarios in the intensive care unit? The antibiotic story

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2814%2970036-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2814%2970036-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Adequacy of early empiric antibiotic treatment and survival in severe sepsis: experience from the MONARCS trial

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2814%2970036-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Impact of goal-oriented and model-based clinical pharmacokinetic dosing of aminoglycosides on clinical outcome: a cost-effectiveness analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2814%2970036-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Optimal exposures of ceftazidime predict the probability of microbiological and clinical outcome in the treatment of nosocomial pneumonia

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2814%2970036-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Increased amikacin dosage requirements in burn patients receiving a once-daily regimen

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2814%2970036-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Aminoglycoside volume of distribution and illness severity in critically ill septic patients

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2814%2970036-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Plasma and tissue pharmacokinetics of cefpirome in patients with sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2814%2970036-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Implications of augmented renal clearance in critically ill patients

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2814%2970036-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Subtherapeutic Initial β-Lactam Concentrations in Select Critically Ill Patients

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2814%2970036-2

7 January 2021

based on heuristic

inferred from DOI database lookup

A multi-centre evaluation of the RIFLE criteria for early acute kidney injury in critically ill patients

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2814%2970036-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Septic Acute Kidney Injury in Critically Ill Patients: Clinical Characteristics and Outcomes

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2814%2970036-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Comparative Activity of Carbapenem Testing (COMPACT) study in Germany

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2814%2970036-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Comparative in vivo efficacy of meropenem, imipenem, and cefepime against Pseudomonas aeruginosa expressing MexA-MexB-OprM efflux pumps

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2814%2970036-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Bacterial-population responses to drug-selective pressure: examination of garenoxacin's effect on Pseudomonas aeruginosa

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2814%2970036-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Testing the mutant selection window hypothesis with Staphylococcus aureus exposed to daptomycin and vancomycin in an in vitro dynamic model

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2814%2970036-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Prevention of resistance: a goal for dose selection for antimicrobial agents

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2814%2970036-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Piperacillin-tazobactam for Pseudomonas aeruginosa infection: clinical implications of an extended-infusion dosing strategy

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2814%2970036-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Hepatic drug metabolism in critical illness

1 reference

https://pubmed.ncbi.nlm.nih.gov/24768475

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/S1473-3099(14)70036-2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24768475%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24768475%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24768475%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

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