(Q34276030)

1 August 2017

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title

Potential biologic agents for treating rheumatoid arthritis (English)

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1 August 2017

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Moreland LW

1

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1 August 2017

publication date

1 May 2001

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Rheumatic Diseases Clinics of North America

1 August 2017

published in

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1 August 2017

volume

27

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1 August 2017

issue

2

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1 August 2017

page(s)

445-491

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CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris

1 August 2017

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7 January 2021

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7 January 2021

Interleukin 6 is required for the development of collagen-induced arthritis

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7 January 2021

A synthetic peptide metalloproteinase inhibitor, but not TIMP, prevents the breakdown of proteoglycan within articular cartilage in vitro

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7 January 2021

Transforming growth factor-beta causes partial inhibition of interleukin 1-stimulated cartilage degradation in vitro

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7 January 2021

Interleukin 1 receptor antagonist. A new member of the interleukin 1 family

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7 January 2021

Taxol involution of collagen-induced arthritis: ultrastructural correlation with the inhibition of synovitis and neovascularization

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7 January 2021

CD44: one ligand, two functions

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7 January 2021

Circadian rhythm of serum interleukin-6 in rheumatoid arthritis

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7 January 2021

Interleukin 2 receptor-targeted cytotoxicity. Interleukin 2 receptor-mediated action of a diphtheria toxin-related interleukin 2 fusion protein

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7 January 2021

Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis

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7 January 2021

Human chemokines: an update

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7 January 2021

Identification of residues on CD40 and its ligand which are critical for the receptor-ligand interaction

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7 January 2021

Prevention of murine collagen-induced arthritis in the knee and ipsilateral paw by local expression of human interleukin-1 receptor antagonist protein in the knee

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7 January 2021

Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer

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7 January 2021

Possible role of V beta T cell receptor genes in susceptibility to collagen-induced arthritis in mice

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7 January 2021

Interleukin 12: a new clinical player in cytokine therapy

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7 January 2021

Polyclonal antibody directed against human RANTES ameliorates disease in the Lewis rat adjuvant-induced arthritis model

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7 January 2021

The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1.

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7 January 2021

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

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7 January 2021

Efficacy of sustained blood levels of interleukin-1 receptor antagonist in animal models of arthritis: comparison of efficacy in animal models with human clinical data

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7 January 2021

Reduction of tumor necrosis factor ? and interleukin-1? levels in human synovial tissue by interleukin-4 and glucocorticoid

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7 January 2021

Increased expression of CD40 ligand (CD154) on CD4+ T cells as a marker of disease activity in rheumatoid arthritis

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7 January 2021

Interrelationships between interleukin (IL)-1, IL-6 and IL-8 in synovial fluid of various arthropathies.

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7 January 2021

Attenuation of collagen-induced arthritis in mice by treatment with vector cells engineered to secrete interleukin-13

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7 January 2021

TNF, apoptosis and autoimmunity: a common thread?

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7 January 2021

Hyaluronan and type III procollagen peptide concentrations in bronchoalveolar lavage fluid in idiopathic pulmonary fibrosis

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7 January 2021

Interleukin 6 knock-out mice are resistant to antigen-induced experimental arthritis

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7 January 2021

Macrophage deactivation by interleukin 10

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7 January 2021

Changes in cartilage composition and physical properties due to stromelysin degradation

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7 January 2021

Interleukin-1 receptor antagonist

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7 January 2021

Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist

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7 January 2021

Joint destruction in arthritis: metalloproteinases in the spotlight

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7 January 2021

Interleukin 4 inhibits polyclonal immunoglobulin secretion and cytokine production by peripheral blood mononuclear cells from rheumatoid arthritis patients

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7 January 2021

Biased t cell receptor v gene usage in rheumatoid arthritis. oligoclonal expansion of t cells expressing vα2 genes in synovial fluid but not in peripheral blood

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7 January 2021

Characterization of T-cell receptor alpha beta repertoire in synovial tissue from different temporal phases of rheumatoid arthritis

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7 January 2021

Therapeutic potential for blockade of the CD40 ligand, gp39.

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7 January 2021

Anti-IL-12 and anti-TNF antibodies synergistically suppress the progression of murine collagen-induced arthritis

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7 January 2021

The relation between major histocompatibility complex (MHC) restriction and the capacity of Ia to bind immunogenic peptides

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7 January 2021

CD44 is necessary for optimal contact allergic responses but is not required for normal leukocyte extravasation

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7 January 2021

Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis. The IL-1Ra Arthritis Study Group

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7 January 2021

Double-blind trial of recombinant gamma-interferon versus placebo in the treatment of rheumatoid arthritis

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7 January 2021

Deficient Fas ligand expression by synovial lymphocytes from patients with rheumatoid arthritis

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7 January 2021

Systemic administration of TIMP in the treatment of collagen-induced arthritis in mice

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7 January 2021

Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant

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7 January 2021

Unconventional T-cell activation by IL-15 in rheumatoid arthritis

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7 January 2021

Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein

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7 January 2021

Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysacchari

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7 January 2021

Interleukin 10 (IL-10) upregulates IL-1 receptor antagonist production from lipopolysaccharide-stimulated human polymorphonuclear leukocytes by delaying mRNA degradation

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7 January 2021

Proteinases and inhibitors

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7 January 2021

Interleukin 16 and its function as a CD4 ligand

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7 January 2021

Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium

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7 January 2021

Tetracyclines inhibit Porphyromonas gingivalis-induced alveolar bone loss in rats by a non-antimicrobial mechanism

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7 January 2021

Therapy against murine collagen-induced arthritis with T cell receptor Vβ-specific antibodies

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7 January 2021

Differential effects of interleukins 10 and 4 on the production of interleukin‐6 by blood and synovium monocytes in rheumatoid arthritis

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7 January 2021

Regulation of the expression of tissue inhibitor of metalloproteinases and collagenase by retinoids and glucocorticoids in human fibroblasts

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7 January 2021

Human placenta-eluted gammaglobulins in immunomodulating treatment of rheumatoid arthritis

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7 January 2021

Diversity of rheumatoid synovial tissue T cells by T cell receptor analysis. Oligoclonal expansion in interleukin-2-responsive cells

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7 January 2021

Increased usage of V beta 2 and V beta 6 in rheumatoid synovial fluid T cells

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7 January 2021

Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice.

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7 January 2021

Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression

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7 January 2021

Elevated interleukin-10 levels in patients with rheumatoid arthritis

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7 January 2021

CD40-CD40 ligand interaction in autoimmune disease

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7 January 2021

Patterns of T-cell receptor variable beta gene expression by synovial fluid and peripheral blood T-cells in rheumatoid arthritis

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7 January 2021

Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells

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7 January 2021

Interleukin-8 secretion and 15-lipoxygenase activity in rheumatoid arthritis: in vitro anti-inflammatory effects by interleukin-4 and interleukin-10, but not by interleukin-1 receptor antagonist protein

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7 January 2021

Clonal V alpha 12.1+ T cell expansions in the peripheral blood of rheumatoid arthritis patients

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7 January 2021

Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production

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7 January 2021

Recombinant human interleukin-1 receptor type I in the treatment of patients with active rheumatoid arthritis

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7 January 2021

Clonal heterogeneity of synovial fluid T lymphocytes from patients with rheumatoid arthritis

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7 January 2021

Antibody to the ligand of CD40, gp39, blocks the occurrence of the acute and chronic forms of graft-vs-host disease

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7 January 2021

Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40

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7 January 2021

Costimulation: building an immunological synapse

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7 January 2021

Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist

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7 January 2021

The role of alphav integrins during angiogenesis: insights into potential mechanisms of action and clinical development.

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7 January 2021

The prevention of collagen breakdown in bovine nasal cartilage by TIMP, TIMP-2 and a low molecular weight synthetic inhibitor

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7 January 2021

Experimental arthritis induced by continuous infusion of IL-8 into rabbit knee joints

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7 January 2021

Gene therapy for rheumatic diseases

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7 January 2021

Vascular permeability factor/endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue

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7 January 2021

The American College of Rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials. The Committee on Outcome Measures in Rheumatoid Arthritis Clinical Trials

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7 January 2021

Interleukin-6 localisation in the synovial membrane in rheumatoid arthritis

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7 January 2021

Interleukin 6 promotes murine lupus in NZB/NZW F1 mice

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7 January 2021

Treatment of murine lupus with CTLA4Ig

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7 January 2021

Novel therapeutic strategies involving animals, arthritis, and apoptosis.

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7 January 2021

Apoptosis in rheumatoid arthritis synovium

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https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970212-X

7 January 2021

Gene expression (collagenase, tissue inhibitor of metalloproteinases, complement, and HLA-DR) in rheumatoid arthritis and osteoarthritis synovium. Quantitative analysis and effect of intraarticular corticosteroids

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7 January 2021

Mechanisms of methotrexate action in rheumatoid arthritis. Selective decrease in synovial collagenase gene expression

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7 January 2021

Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis

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7 January 2021

Limited heterogeneity of rearranged T cell receptor V alpha and V beta transcripts in synovial fluid T cells in early stages of rheumatoid arthritis

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7 January 2021

Radiologic evidence of disease modification in rheumatoid arthritis patients treated with cyclosporine. Results of a 48-week multicenter study comparing low-dose cyclosporine with placebo. Norwegian Arthritis Study Group

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7 January 2021

T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines

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7 January 2021

In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39

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7 January 2021

Therapeutic effect of the anti-Fas antibody on arthritis in HTLV-1 tax transgenic mice

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7 January 2021

Requirement for CD8+ cells in T cell receptor peptide-induced clonal unresponsiveness

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7 January 2021

Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells

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7 January 2021

Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia

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7 January 2021

Administration of interleukin 12 in combination with type II collagen induces severe arthritis in DBA/1 mice

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7 January 2021

Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases

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7 January 2021

Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva.

1 reference

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970212-X

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970212-X

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7 January 2021

Dominant clonotypes in the repertoire of peripheral CD4+ T cells in rheumatoid arthritis

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https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970212-X

7 January 2021

T-cell receptors and collagen induced arthritis in H-2r mice

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970212-X

7 January 2021

Dominant T-cell-receptor beta chain variable region V beta 14+ clones in juvenile rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970212-X

7 January 2021

Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-gamma in murine macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970212-X

7 January 2021

Structures on the I-A molecule predisposing for susceptibility to type II collagen-induced autoimmune arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970212-X

7 January 2021

Aberrant expression of HLA-DR antigen on thyrocytes in Graves' disease: relevance for autoimmunity

1 reference

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7 January 2021

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970212-X

7 January 2021

Rheumatoid arthritis. Pathophysiology and implications for therapy

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https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970212-X

7 January 2021

Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970212-X

7 January 2021

C-myc antisense oligodeoxynucleotides can induce apoptosis and down-regulate Fas expression in rheumatoid synoviocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970212-X

7 January 2021

Accumulation of soluble Fas in inflamed joints of patients with rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970212-X

7 January 2021

Sensitive ELISA for interleukin-6. Detection of IL-6 in biological fluids: synovial fluids and sera

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970212-X

7 January 2021

Inhibition of interleukin-1-induced synovitis and articular cartilage proteoglycan loss in the rabbit knee by recombinant human interleukin-1 receptor antagonist.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970212-X

7 January 2021

Important immunoregulatory role of interleukin-11 in the inflammatory process in rheumatoid arthritis

1 reference

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7 January 2021

Anti-CD4 antibody treatment of patients with rheumatoid arthritis: I. Effect on clinical course and circulating T cells

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7 January 2021

IL-4 down-regulates the surface expression of CD5 on B cells and inhibits spontaneous immunoglobulin and IgM-rheumatoid factor production in patients with rheumatoid arthritis

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7 January 2021

T lymphocytes in collagen II-induced arthritis in mice. Characterization of arthritogenic collagen II-specific T-cell lines and clones

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7 January 2021

Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II

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7 January 2021

Effects of various anti-T cell receptor antibodies on the development of type II collagen-induced arthritis in mice

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7 January 2021

Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice

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https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970212-X

7 January 2021

Treatment of rheumatoid arthritis with an anti-CD4 monoclonal antibody

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970212-X

7 January 2021

Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides

1 reference

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7 January 2021

Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis

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7 January 2021

Limited T-cell receptor beta-chain heterogeneity among interleukin 2 receptor-positive synovial T cells suggests a role for superantigen in rheumatoid arthritis

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7 January 2021

Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system

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7 January 2021

Prevention of autoimmune diabetes in non-obese diabetic mice by treatment with a class II major histocompatibility complex-blocking peptide

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7 January 2021

Polyclonal origin of rheumatoid synovial T-lymphocytes

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7 January 2021

High frequencies of identical T cell clonotypes in synovial tissues of rheumatoid arthritis patients suggest the occurrence of common antigen-driven immune responses

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7 January 2021

CAMPATH-1H in rheumatoid arthritis--an intravenous dose-ranging study

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7 January 2021

Interleukin-10 functions as an antiinflammatory cytokine in rheumatoid synovium

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7 January 2021

The presence of interleukin-13 in rheumatoid synovium and its antiinflammatory effects on synovial fluid macrophages from patients with rheumatoid arthritis

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7 January 2021

Humanised monoclonal antibody therapy for rheumatoid arthritis

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7 January 2021

Effects of interleukin-6 on the metabolism of connective tissue components in rheumatoid synovial fibroblasts

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7 January 2021

Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic for HTLV-I.

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7 January 2021

Effects of interferon β-1B in rheumatoid arthritis: A case report

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7 January 2021

Emergence of oligoclonal T cell populations following therapeutic T cell depletion in rheumatoid arthritis

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7 January 2021

T cell receptor V beta gene bias in rheumatoid arthritis

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7 January 2021

A multicenter, double-blind, dose-ranging, randomized, placebo-controlled study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis: radiologic progression and correlation of Genant and Larsen scores

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7 January 2021

Interleukin-4 and interleukin-10 are chondroprotective and decrease mononuclear cell recruitment in human rheumatoid synovium in vivo

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7 January 2021

Systemic viral interleukin-10 gene delivery prevents cartilage invasion by human rheumatoid synovial tissue engrafted in SCID mice

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7 January 2021

Two inhibitors of pro-inflammatory cytokine release, interleukin-10 and interleukin-4, have contrasting effects on release of soluble p75 tumor necrosis factor receptor by cultured monocytes

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7 January 2021

The B7 and CD28 receptor families

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7 January 2021

Lymphapheresis in rheumatoid arthritis. A randomized trial

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7 January 2021

Biphasic regulation of the development of murine type II collagen-induced arthritis by interleukin-12: possible involvement of endogenous interleukin-10 and tumor necrosis factor alpha

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7 January 2021

Immunoregulatory role of interleukin 10 in rheumatoid arthritis

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7 January 2021

Treatment of refractory rheumatoid arthritis with a monoclonal antibody to intercellular adhesion molecule 1

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7 January 2021

Inhibition of Fas antigen-mediated apoptosis of rheumatoid synovial cells in vitro by transforming growth factor beta 1

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7 January 2021

Structure of T cell antigen receptor beta chain in synovial fluid cells from patients with rheumatoid arthritis

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7 January 2021

Structural motifs in rheumatoid T-cell receptors

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7 January 2021

Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates

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7 January 2021

Minocycline in active rheumatoid arthritis. A double-blind, placebo-controlled trial

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7 January 2021

Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig

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7 January 2021

Apomodulation as a novel therapeutic concept for the regulation of apoptosis in rheumatoid synoviocytes

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7 January 2021

Tumor necrosis factor alpha regulation of the FAS-mediated apoptosis-signaling pathway in synovial cells

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7 January 2021

Review: angiogenesis: implications for rheumatoid arthritis

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7 January 2021

Expression of interleukin-1 and interleukin-1 receptor antagonist by human rheumatoid synovial tissue macrophages

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7 January 2021

Interleukin-8 as a macrophage-derived mediator of angiogenesis

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7 January 2021

Oligoclonal T cells in rheumatoid arthritis: identification strategy and molecular characterization of a clonal T-cell receptor

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7 January 2021

Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes

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7 January 2021

Targeting the T cell receptor in rheumatoid arthritis

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7 January 2021

Anti-Ia treatment prevents lupus-like autoimmune syndrome in mice neonatally tolerized to alloantigens

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7 January 2021

T cell receptor variable region repertoire in lymphocytes from rheumatoid arthritis patients

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7 January 2021

Interleukin-1 beta converting enzyme inhibition blocks progression of type II collagen-induced arthritis in mice

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7 January 2021

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy

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7 January 2021

Vaccination with T cell receptor peptides primes anti-receptor cytotoxic T lymphocytes (CTL) and anergizes T cells specifically recognized by these CTL

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7 January 2021

The involvement of T cell receptor peptide-specific regulatory CD4+ T cells in recovery from antigen-induced autoimmune disease

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7 January 2021

Therapy with monoclonal antibody to interleukin 2 receptor spares suppressor T cells and prevents or reverses acute allograft rejection in rats

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7 January 2021

Beneficial effect of monoclonal antibody to interleukin 2 receptor on activated T cells in rheumatoid arthritis

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7 January 2021

IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes

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7 January 2021

Suppression of metalloproteinase biosynthesis in human alveolar macrophages by interleukin-4

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7 January 2021

1 reference

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7 January 2021

Inhibition of antigen presentation in vitro and in vivo by MHC antagonist peptides

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7 January 2021

Analysis of T cell receptors in rheumatoid arthritis: the increased expression of HLA-DR antigen on circulating gamma delta+ T cells is correlated with disease activity

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7 January 2021

Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference films

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7 January 2021

p38 mitogen-activated protein kinase inhibitors--mechanisms and therapeutic potentials

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7 January 2021

Therapeutic effects of genetically engineered toxin (DAB486IL-2) in patient with chronic lymphocytic leukaemia

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7 January 2021

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse

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7 January 2021

Interferon-beta1A-induced polyarthritis in a patient with the HLA-DRB1*0404 allele

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7 January 2021

Ro 32-3555, an orally active collagenase inhibitor, prevents cartilage breakdown in vitro and in vivo

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7 January 2021

Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock

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7 January 2021

Therapeutic vaccination against adjuvant arthritis using autoimmune T cells treated with hydrostatic pressure

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7 January 2021

CTLA-4 is a second receptor for the B cell activation antigen B7

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7 January 2021

Mouse/human chimeric monoclonal antibody in man: kinetics and immune response

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7 January 2021

An altered repertoire of T cell receptor V gene expression by rheumatoid synovial fluid T lymphocytes

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7 January 2021

Functional CD40 ligand is expressed by T cells in rheumatoid arthritis

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7 January 2021

Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis

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7 January 2021

Recombinant human interferon gamma in the treatment of rheumatoid arthritis: double blind placebo controlled study

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7 January 2021

Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy

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7 January 2021

Blockade of IL-12 during the induction of collagen-induced arthritis (CIA) markedly attenuates the severity of the arthritis

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7 January 2021

Levels of synovial fluid interleukin-1 receptor antagonist in rheumatoid arthritis and other arthropathies. Potential contribution from synovial fluid neutrophils

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7 January 2021

Gene Therapy's Growing Pains

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7 January 2021

Interleukin (IL)-10 inhibits long-term IL-6 production but not preformed mediator release from rat peritoneal mast cells

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7 January 2021

Treatment of rheumatoid synovitis with anti-reshaping human interleukin-6 receptor monoclonal antibody: use of rheumatoid arthritis tissue implants in the SCID mouse model.

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7 January 2021

Treatment of active refractory rheumatoid arthritis with humanized monoclonal antibody CAMPATH-1H administered by daily subcutaneous injection

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7 January 2021

Treatment with gamma-interferon triggers the onset of collagen arthritis in mice.

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7 January 2021

Cytokine regulation of metalloproteinase gene expression

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7 January 2021

Immunosuppressive properties of synthetic peptides derived from CD4 and HLA-DR antigens

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7 January 2021

Interleukin 15: a proinflammatory role in rheumatoid arthritis synovitis

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7 January 2021

Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-α production in rheumatoid arthritis

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7 January 2021

The role of interleukin–15 in T–cell migration and activation in rheumatoid arthritis

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7 January 2021

Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient mice

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7 January 2021

Interleukin 6 inhibits delayed-type hypersensitivity and the development of adjuvant arthritis

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7 January 2021

Anti-CD44 treatment abrogates tissue aedema and leukocyte infiltration in murine arthrtis

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7 January 2021

Modulation of hyaluronan receptor (CD44) function in vivo in a murine model of rheumatoid arthritis

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7 January 2021

Dominant T-cell receptor beta-chain gene rearrangements indicate clonal expansion in the rheumatoid joint

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7 January 2021

Interleukin-6 activity in paired samples of synovial fluid. Correlation of synovial fluid interleukin-6 levels with clinical and laboratory parameters of inflammation

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7 January 2021

Low levels of interleukin-4 and high levels of transforming growth factor beta in rheumatoid synovitis

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7 January 2021

Prevention of collagen induced arthritis in mice by treatment with an antibody directed against the T cell receptor alpha beta framework

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7 January 2021

Clinical modeling of T cell vaccination against autoimmune diseases in rats. Selection of antigen-specific T cells using a mitogen

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7 January 2021

Interleukin-2 diphtheria fusion protein (DAB486IL-2) in refractory rheumatoid arthritis. A double-blind, placebo-controlled trial with open-label extension.

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7 January 2021

Double-blind, placebo-controlled multicenter trial using chimeric monoclonal anti-CD4 antibody, cM-T412, in rheumatoid arthritis patients receiving concomitant methotrexate

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7 January 2021

T cell receptor peptide vaccination in rheumatoid arthritis: a placebo-controlled trial using a combination of Vbeta3, Vbeta14, and Vbeta17 peptides

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7 January 2021

Treatment of refractory rheumatoid arthritis with a chimeric anti-CD4 monoclonal antibody. Long-term followup of CD4+ T cell counts

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7 January 2021

Use of a chimeric monoclonal anti-CD4 antibody in patients with refractory rheumatoid arthritis

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7 January 2021

Expression of interleukin-12 in synovial tissue from patients with rheumatoid arthritis

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7 January 2021

Direct evidence for active metalloproteinases mediating matrix degradation in interleukin 1-stimulated human articular cartilage

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7 January 2021

Synergy between T cell receptor beta gene polymorphism and HLA-DR4 in susceptibility to rheumatoid arthritis.

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7 January 2021

Gene transfer of cytokine inhibitors into human synovial fibroblasts in the SCID mouse model

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7 January 2021

In vivo suppression of immune complex-induced alveolitis by secretory leukoproteinase inhibitor and tissue inhibitor of metalloproteinases 2

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7 January 2021

Suppression in murine experimental autoimmune thyroiditis: in vivo inhibition of CD4+ T cell-mediated resistance by a nondepleting rat CD4 monoclonal antibody

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7 January 2021

The effect of treatment with interferon-gamma on type II collagen-induced arthritis

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7 January 2021

Apoptosis and functional Fas antigen in rheumatoid arthritis synoviocytes

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7 January 2021

Genetic control of T cell receptor BJ gene expression in peripheral lymphocytes of normal and rheumatoid arthritis monozygotic twins

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7 January 2021

Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice

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7 January 2021

Interleukin-1-induced interleukin-6 is required for the inhibition of proteoglycan synthesis by interleukin-1 in human articular cartilage

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7 January 2021

Inhibition of epithelial cell matrix metalloproteinases by tetracyclines

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7 January 2021

Apoptosis in rheumatoid arthritis: a novel pathway in the regulation of synovial tissue

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7 January 2021

HLA-dependent peripheral T cell receptor (TCR) repertoire formation and its modification by rheumatoid arthritis (RA)

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7 January 2021

Treatment of early seropositive rheumatoid arthritis with minocycline: four-year followup of a double-blind, placebo-controlled trial

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7 January 2021

Interferon in chronic polyarthritis. Positive effect in clinical evaluation

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7 January 2021

T cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis

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7 January 2021

Role of cytokines in determining T-lymphocyte function

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7 January 2021

Lethal effect of the anti-Fas antibody in mice

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7 January 2021

Interleukin 6 plays a key role in the development of antigen-induced arthritis

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7 January 2021

Variable gene usage of T cell receptor γ- and δ-chain transcripts expressed in synovia and peripheral blood of patients with rheumatoid arthritis

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7 January 2021

A double-blind, placebo-controlled study of anti-CD5 immunoconjugate in patients with rheumatoid arthritis. The Xoma RA Investigator Group

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7 January 2021

Adhesion molecules in rheumatoid arthritis

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7 January 2021

Characterization of the T cell receptor repertoire causing collagen arthritis in mice

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7 January 2021

Modulation of angiogenic vascular endothelial growth factor by tumor necrosis factor alpha and interleukin-1 in rheumatoid arthritis

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7 January 2021

Evidence for the effects of a superantigen in rheumatoid arthritis

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7 January 2021

The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis

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7 January 2021

The pathophysiologic roles of interleukin-6 in human disease

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7 January 2021

Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group

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7 January 2021

Carbohydrate ligands of leukocyte adhesion molecules and their therapeutic potential.

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7 January 2021

Lymphocyte involvement in rheumatoid arthritis. Studies during thoracic duct drainage

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7 January 2021

Angiogenesis inhibition suppresses collagen arthritis

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7 January 2021

Biased T cell receptor V alpha region repertoire in the synovial fluid of rheumatoid arthritis patients

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7 January 2021

The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions

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7 January 2021

Expression of monocyte chemoattractant protein-1 and interleukin-8 receptors on subsets of T cells: correlation with transendothelial chemotactic potential

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7 January 2021

Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4

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7 January 2021

Synergistic effect of interleukin-1 beta and tumor necrosis factor alpha on interleukin-8 gene expression in synovial fibroblasts. Evidence that interleukin-8 is the major neutrophil-activating chemokine released in response to monokine activation

1 reference

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7 January 2021

Treatment of rheumatoid arthritis with monoclonal CD4 antibody M-T151. Clinical results and immunopharmacologic effects in an open study, including repeated administration

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7 January 2021

Profile of cytokines in synovial fluid specimens from patients with arthritis. Interleukin 8 (IL-8) and IL-6 correlate with inflammatory arthritides

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7 January 2021

Adenoviral-mediated gene transfer to rabbit synovium in vivo.

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7 January 2021

The effect of gamma-interferon on MHC antigens

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7 January 2021

Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6

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7 January 2021

Interleukin-10 prevents experimental allergic encephalomyelitis in rats.

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7 January 2021

The soluble interleukin-2 receptor: biology, function, and clinical application

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7 January 2021

Synovial tissue response to treatment with Campath-1H

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7 January 2021

The CD4-associated tyrosine kinase p56lck is required for lymphocyte chemoattractant factor-induced T lymphocyte migration

1 reference

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7 January 2021

Interleukin-6 in synovial fluid is closely associated with chronic synovitis in rheumatoid arthritis

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7 January 2021

Prevention of experimental encephalomyelitis with peptides that block interaction of T cells with major histocompatibility complex proteins

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7 January 2021

Inhibition of T cell apoptosis in the rheumatoid synovium

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7 January 2021

Delayed onset and reduced severity of collagen-induced arthritis in interleukin-6-deficient mice

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7 January 2021

Interleukin 6 enhances the production of tissue inhibitor of metalloproteinases (TIMP) but not that of matrix metalloproteinases by human fibroblasts

1 reference

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7 January 2021

A minority of patients with rheumatoid arthritis show a dominant rearrangement of T-cell receptor beta chain genes in synovial lymphocytes

1 reference

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7 January 2021

Immunomodulatory activity of recombinant IL-1 receptor (IL-1-R) on models of experimental rheumatoid arthritis

1 reference

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7 January 2021

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice

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7 January 2021

Enhanced production of neutrophil-activating peptide-1/interleukin-8 in rheumatoid arthritis

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7 January 2021

The effects of cytokines on metalloproteinase inhibitors (TIMP) and collagenase production by human chondrocytes and TIMP production by synovial cells and endothelial cells

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7 January 2021

Interleukin 4 inhibits murine osteoclast formation in vitro.

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7 January 2021

Differential patterns of response to doxycycline and transforming growth factor beta1 in the down-regulation of collagenases in osteoarthritic and normal human chondrocytes

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7 January 2021

The nature of the principal type 1 interferon-producing cells in human blood

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7 January 2021

Divergent T-cell cytokine patterns in inflammatory arthritis

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7 January 2021

The effects of interferon-beta treatment of synovial inflammation and expression of metalloproteinases in patients with rheumatoid arthritis

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7 January 2021

Specificity of inhibition of matrix metalloproteinase activity by doxycycline: relationship to structure of the enzyme

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7 January 2021

Interleukin-2: inception, impact, and implications

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7 January 2021

Biologic effects of an interleukin-1 receptor antagonist protein on interleukin-1–stimulated cartilage erosion and chondrocyte responsiveness

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7 January 2021

Restricted expression of T cell receptor V beta but not V alpha genes in rheumatoid arthritis

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7 January 2021

Clonal dominance among T-lymphocyte infiltrates in arthritis

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7 January 2021

In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis

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7 January 2021

Decreased angiogenesis and arthritic disease in rabbits treated with an alphavbeta3 antagonist.

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7 January 2021

Effects of administration of an anti-CD5 plus immunoconjugate in rheumatoid arthritis. Results of two phase II studies. The CD5 Plus Rheumatoid Arthritis Investigators Group

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7 January 2021

Efficacy of total lymphoid irradiation in intractable rheumatoid arthritis. A double-blind, randomized trial

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7 January 2021

Molecular analysis of the T-cell receptor beta-chain repertoire in early rheumatoid arthritis: heterogeneous TCRBV gene usage with shared amino acid profiles in CDR3 regions of T lymphocytes in multiple synovial tissue needle biopsies from the same

1 reference

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7 January 2021

T-cell receptor V-gene usage in synovial fluid lymphocytes of patients with chronic arthritis

1 reference

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7 January 2021

Suppressive effect of interleukin-4 (IL-4) on IL-6 production by adherent rheumatoid synovial cells

1 reference

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7 January 2021

The role of p38 mitogen-activated protein kinase in IL-6 and IL-8 production from the TNF-alpha- or IL-1beta-stimulated rheumatoid synovial fibroblasts

1 reference

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7 January 2021

Acute lung injury fibroblast migration and invasion of a fibrin matrix is mediated by CD44.

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7 January 2021

Purification and characterization of a novel soluble receptor for interleukin 1

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7 January 2021

Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis

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7 January 2021

A role for CD5 in TCR-mediated signal transduction and thymocyte selection

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7 January 2021

Monocyte chemotactic protein-1 (MCP-1), -2, and -3 are chemotactic for human T lymphocytes

1 reference

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7 January 2021

Inhibition of lymphocyte adhesion to cytokine-activated synovial fibroblasts by glucocorticoids involves the attenuation of vascular cell adhesion molecule 1 and intercellular adhesion molecule 1 gene expression

1 reference

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7 January 2021

Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. The IFNB Multiple Sclerosis Study Group

1 reference

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7 January 2021

The stress-activated protein kinase pathways

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7 January 2021

Minocycline in rheumatoid arthritis. A 48-week, double-blind, placebo-controlled trial. MIRA Trial Group.

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7 January 2021

A synthetic peptide from the third hypervariable region of major histocompatibility complex class II beta chain as a vaccine for treatment of experimental autoimmune encephalomyelitis

1 reference

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7 January 2021

Monocyte activation in rheumatoid arthritis (RA): increased integrin, Fc gamma and complement receptor expression and the effect of glucocorticoids

1 reference

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7 January 2021

Amelioration of collagen-induced arthritis and suppression of interferon-gamma, interleukin-12, and tumor necrosis factor alpha production by interferon-beta gene therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970212-X

7 January 2021

The T-cell-receptor repertoire in the synovial fluid of a patient with rheumatoid arthritis is polyclonal

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970212-X

7 January 2021

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970212-X

7 January 2021

Amelioration of established murine collagen-induced arthritis with anti-IL-1 treatment

1 reference

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7 January 2021

The role of cytokines and growth factors in cartilage destruction in osteoarthritis and rheumatoid arthritis

1 reference

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7 January 2021

A randomized, double‐blind, placebo‐controlled study of cd4 monoclonal antibody therapy in early rheumatoid arthritis

1 reference

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7 January 2021

Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans

1 reference

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7 January 2021

Lack of T cell oligoclonality in enzyme-digested synovial tissue and in synovial fluid in most patients with rheumatoid arthritis

1 reference

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7 January 2021

Prevention and reversal of cartilage degradation in rheumatoid arthritis by interleukin-10 and interleukin-4

1 reference

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7 January 2021

Treatment of multiple sclerosis with T-cell receptor peptides: results of a double-blind pilot trial

1 reference

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7 January 2021

Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis

1 reference

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7 January 2021

Identification of overrepresented T cell receptor genes in blood and tissue biopsies by PCR-ELISA

1 reference

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7 January 2021

Coordinated antiinflammatory effects of interleukin 4: interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist

1 reference

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7 January 2021

Intra-articular primatised anti-CD4: efficacy in resistant rheumatoid knees. A study of combined arthroscopy, magnetic resonance imaging, and histology

1 reference

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7 January 2021

Elevated synovial fluid levels of interleukin-6 and tumor necrosis factor associated with early experimental canine osteoarthritis

1 reference

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7 January 2021

Administration of antibodies to hyaluronanreceptor (CD44) delays the start and ameliorates the severity of collagen II arthritis

1 reference

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7 January 2021

Using inhibitors of metalloproteinases to treat arthritis. Easier said than done?

1 reference

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7 January 2021

Interleukin-6 in synovial fluid from patients with arthritis

1 reference

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7 January 2021

Oligoclonal T cell proliferation in patients with rheumatoid arthritis and their unaffected siblings

1 reference

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7 January 2021

Modulation by proinflammatory cytokines of Fas/Fas ligand-mediated apoptotic cell death of synovial cells in patients with rheumatoid arthritis (RA)

1 reference

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7 January 2021

The multichain interleukin-2 receptor: a target for immunotherapy

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7 January 2021

In vivo therapy with monoclonal anti-I-A antibody suppresses immune responses to acetylcholine receptor

1 reference

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7 January 2021

A double-blind, controlled study of lymphoplasmapheresis versus sham apheresis in rheumatoid arthritis

1 reference

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7 January 2021

Interleukin-10 inhibition of the progression of established collagen-induced arthritis

1 reference

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7 January 2021

Anti-C5 monoclonal antibody therapy prevents collagen-induced arthritis and ameliorates established disease

1 reference

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7 January 2021

Interleukin-4 as a potent inhibitor of bone resorption

1 reference

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7 January 2021

Angiogenesis induced by degradation products of hyaluronic acid.

1 reference

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7 January 2021

Correlation between disease phenotype and genetic heterogeneity in rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970212-X

7 January 2021

Homozygosity for the HLA-DRB1 allele selects for extraarticular manifestations in rheumatoid arthritis

1 reference

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7 January 2021

The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis

1 reference

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7 January 2021

Diphtheria toxin receptor binding domain substitution with interleukin-2: genetic construction and properties of a diphtheria toxin-related interleukin-2 fusion protein

1 reference

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7 January 2021

Paradoxical effects of a synthetic metalloproteinase inhibitor that blocks both p55 and p75 TNF receptor shedding and TNF alpha processing in RA synovial membrane cell cultures

1 reference

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7 January 2021

Conserved motifs in rheumatoid arthritis synovial tissue T-cell receptor beta chains

1 reference

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7 January 2021

Restricted heterogeneity of T cell receptor transcripts in rheumatoid synovium

1 reference

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7 January 2021

The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase

1 reference

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7 January 2021

Mechanism of first-dose cytokine-release syndrome by CAMPATH 1-H: involvement of CD16 (FcgammaRIII) and CD11a/CD18 (LFA-1) on NK cells

1 reference

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7 January 2021

Multiple actions of interleukin 6 within a cytokine network

1 reference

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7 January 2021

Interleukin (IL) 4 differentially regulates monocyte IL-1 family gene expression and synthesis in vitro and in vivo

1 reference

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7 January 2021

The effect of an interleukin-1 receptor antagonist protein on type II collagen-induced arthritis and antigen-induced arthritis in mice

1 reference

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7 January 2021

Pristane-induced arthritis in mice. V. Susceptibility to pristane-induced arthritis is determined by the genetic regulation of the T cell repertoire

1 reference

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7 January 2021

IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

1 reference

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7 January 2021

Transforming growth factor beta stimulates the production of the tissue inhibitor of metalloproteinases (TIMP) by human synovial and skin fibroblasts

1 reference

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7 January 2021

The secretion of the tissue inhibitor of metalloproteinases (TIMP) by human synovial fibroblasts is modulated by all-trans-retinoic acid

1 reference

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7 January 2021

IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970212-X

7 January 2021

Characterization of the CAMPATH-1 (CDw52) antigen: biochemical analysis and cDNA cloning reveal an unusually small peptide backbone

1 reference

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7 January 2021

Inflammatory polyarthritis in mice transgenic for human T cell leukemia virus type I.

1 reference

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7 January 2021

Functional interactions of T cells with endothelial cells: the role of CD40L-CD40-mediated signals

1 reference

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7 January 2021

Immunohistologic analysis of renal CD40 and CD40L expression in lupus nephritis and other glomerulonephritides

1 reference

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7 January 2021

Enhancement of T-cell-mediated arthritis in mice by treatment with a monoclonal antibody against interleukin-4.

1 reference

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7 January 2021

Suppression of chronic antigen-induced arthritis in rats by a monoclonal antibody against the T cell receptor alpha beta

1 reference

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7 January 2021

Suppression and prevention of adjuvant arthritis in rats by a monoclonal antibody to the α/β T cell receptor

1 reference

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7 January 2021

The suppressive effect of an antibody to the alpha beta cell receptor in rat adjuvant arthritis: studies on optimal treatment protocols

1 reference

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7 January 2021

Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody

1 reference

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7 January 2021

Neutrophil trafficking into inflamed joints in patients with rheumatoid arthritis, and the effects of methylprednisolone

1 reference

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7 January 2021

Peripheral blood Ia-positive T cells. Increases in certain diseases and after immunization

1 reference

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7 January 2021

Increased frequency of V beta 17-positive T cells in patients with rheumatoid arthritis

1 reference

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7 January 2021

Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970212-X

7 January 2021

Induction of apoptosis in mature T cells by tumour necrosis factor

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7 January 2021

10.1016/S0889-857X(05)70212-X

Identifiers

DOI

1 reference

1 August 2017

1 reference