(Q34283469)

1 August 2017

1 reference

title

The role of p53 in human cancer (English)

1 reference

1 August 2017

Malkin D

1

1 reference

1 August 2017

publication date

1 February 2001

1 reference

Journal of Neuro-Oncology

1 August 2017

published in

1 reference

1 August 2017

volume

51

1 reference

1 August 2017

issue

3

1 reference

1 August 2017

page(s)

231-243

1 reference

https://scigraph.springernature.com/pub.10.1023/a:1010636426860

1 August 2017

exact match

0 references

cites work

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation

1 reference

12 December 2020

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1 reference

12 December 2020

Cancer phenotype correlates with constitutional TP53 genotype in families with the Li-Fraumeni syndrome.

1 reference

12 December 2020

Li-Fraumeni syndrome--a molecular and clinical review

1 reference

12 December 2020

A model for p53-induced apoptosis

1 reference

12 December 2020

Solution structure of the tetrameric minimum transforming domain of p53

1 reference

12 December 2020

1 reference

12 December 2020

Abrogation of wild-type p53 mediated growth-inhibition by nuclear exclusion.

1 reference

12 December 2020

Nuclear and nucleolar targeting sequences of c-erb-A, c-myb, N-myc, p53, HSP70, and HIV tat proteins

1 reference

12 December 2020

p21 inhibits cyclin shock

1 reference

12 December 2020

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

1 reference

12 December 2020

Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis

1 reference

12 December 2020

T antigen is bound to a host protein in SY40-transformed cells

1 reference

12 December 2020

A simple p53 functional assay for screening cell lines, blood, and tumors

1 reference

12 December 2020

Choroid plexus tumors in the breast cancer-sarcoma syndrome.

1 reference

12 December 2020

Human TAFII31 protein is a transcriptional coactivator of the p53 protein

1 reference

12 December 2020

p53 mediated sensitization of squamous cell carcinoma of the head and neck to radiotherapy

1 reference

12 December 2020

Cloning and functional analysis of human p51, which structurally and functionally resembles p53

1 reference

12 December 2020

Predominantly tumor-limited expression of a mutant allele in a Japanese family carrying a germline p53 mutation

1 reference

12 December 2020

A novel deletion within exon 6 of TP53 in a family with Li-Fraumeni-like syndrome, and LOH in a benign lesion from a mutation carrier

1 reference

12 December 2020

Adenovirus-mediated transfer of a wild-type p53 gene and induction of apoptosis in cervical cancer

1 reference

12 December 2020

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

1 reference

12 December 2020

Thymocyte apoptosis induced by p53-dependent and independent pathways.

1 reference

12 December 2020

Statement of the American Society of Clinical Oncology: genetic testing for cancer susceptibility, Adopted on February 20, 1996

1 reference

12 December 2020

p53 mutations increase resistance to ionizing radiation

1 reference

12 December 2020

mdm2 expression is induced by wild type p53 activity

1 reference

12 December 2020

A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice

1 reference

12 December 2020

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

1 reference

12 December 2020

KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

1 reference

12 December 2020

Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stress

1 reference

12 December 2020

High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene

1 reference

12 December 2020

Wild-type p53 can inhibit oncogene-mediated focus formation

1 reference

12 December 2020

Adenovirus-mediated wild-type p53 gene transfer as a surgical adjuvant in advanced head and neck cancers.

1 reference

12 December 2020

Clinical implications of the p53 tumor-suppressor gene

1 reference

12 December 2020

Germline p53 mutations are frequently detected in young children with rhabdomyosarcoma

1 reference

12 December 2020

Mutations in the p53 gene occur in diverse human tumour types

1 reference

12 December 2020

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

1 reference

12 December 2020

Tumor spectrum analysis in p53-mutant mice

1 reference

12 December 2020

Genetic transmission of susceptibility to cancer in families of children with soft tissue sarcomas.

1 reference

12 December 2020

1 reference

12 December 2020

Germline mutations of the p53 tumor suppressor gene in children with osteosarcoma

1 reference

12 December 2020

Multiple primary cancers in families with Li-Fraumeni syndrome

1 reference

12 December 2020

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1 reference

12 December 2020

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo

1 reference

12 December 2020

Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome

1 reference

12 December 2020

p53 is required for radiation-induced apoptosis in mouse thymocytes

1 reference

12 December 2020

p53 in growth control and neoplasia

1 reference

12 December 2020

Cooperative tumorigenic effects of germline mutations in Rb and p53

1 reference

12 December 2020

p53, the cellular gatekeeper for growth and division

1 reference

12 December 2020

A phase I study of adenovirus-mediated wild-type p53 gene transfer in patients with advanced non-small cell lung cancer

1 reference

12 December 2020

Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome?

1 reference

12 December 2020

Follow-up study of twenty-four families with Li-Fraumeni syndrome

1 reference

12 December 2020

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

1 reference

12 December 2020

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1 reference

12 December 2020

Inherited p53 gene mutations in breast cancer

1 reference

12 December 2020

Induction of the growth inhibitor IGF-binding protein 3 by p53

1 reference

12 December 2020

Mutation and expression analysis of the p73 gene in prostate cancer

1 reference

12 December 2020

MDM2 and MDMX bind and stabilize the p53-related protein p73

1 reference

12 December 2020

Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

1 reference

12 December 2020

Database and software for the analysis of mutations in the human p53 gene.

1 reference

12 December 2020

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

1 reference

12 December 2020

Regulation of p53 in response to DNA damage

1 reference

12 December 2020

Prevalence and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni families.

1 reference

12 December 2020

Oxidative damage in chemical teratogenesis

1 reference

12 December 2020

Screening for germ line TP53 mutations in breast cancer patients

1 reference

12 December 2020

A p53-dependent mouse spindle checkpoint

1 reference

12 December 2020

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

1 reference

12 December 2020

Are there low-penetrance TP53 Alleles? evidence from childhood adrenocortical tumors

1 reference

12 December 2020

Abnormal centrosome amplification in the absence of p53.

1 reference

12 December 2020

Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage

1 reference

12 December 2020

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

1 reference

12 December 2020

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

1 reference

12 December 2020

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

12 December 2020

Caspases: intracellular signaling by proteolysis

1 reference

12 December 2020

An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

1 reference

12 December 2020

p63 and p73: old members of a new family

1 reference

12 December 2020

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

1 reference

12 December 2020

DNA damage activates p53 through a phosphorylation-acetylation cascade

1 reference

12 December 2020

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

12 December 2020

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1 reference

12 December 2020

Twenty years of p53 research: structural and functional aspects of the p53 protein

1 reference

12 December 2020

Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.

1 reference

12 December 2020

Growth factor modulation of p53-mediated growth arrest versus apoptosis

1 reference

12 December 2020

Participation of p53 protein in the cellular response to DNA damage

1 reference

12 December 2020

A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis

1 reference

12 December 2020

p53 function and dysfunction

1 reference

12 December 2020

A teratologic suppressor role for p53 in benzo[a]pyrene-treated transgenic p53-deficient mice.

1 reference

12 December 2020

Germ-line mutations of TP53 in Li-Fraumeni families: an extended study of 39 families

1 reference

12 December 2020

Statement of the American Society of Human Genetics on genetic testing for breast and ovarian cancer predisposition

1 reference

12 December 2020

Adenovirus-mediated p53 gene delivery potentiates the radiation-induced growth inhibition of experimental brain tumors

1 reference

12 December 2020

p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent

1 reference

12 December 2020

p73 is a simian [correction of human] p53-related protein that can induce apoptosis

1 reference

12 December 2020

Tumors associated with p53 germline mutations: a synopsis of 91 families.

1 reference

12 December 2020

Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene

1 reference

12 December 2020

The p73 gene is not mutated in oligodendrogliomas which frequently have a deleted region at chromosome 1p36.3.

1 reference

12 December 2020

Genetic determinants of p53-induced apoptosis and growth arrest

1 reference

12 December 2020

High-resolution structure of the oligomerization domain of p53 by multidimensional NMR

1 reference

12 December 2020

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

1 reference

12 December 2020

Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

1 reference

12 December 2020

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1 reference

12 December 2020

p53 compound heterozygosity in a severely affected child with Li-Fraumeni syndrome

1 reference

12 December 2020

Germ-line p53 mutations in 15 families with Li-Fraumeni syndrome.

1 reference

12 December 2020

1 reference

12 December 2020

Identification of a transactivation activity in the COOH-terminal region of p73 which is impaired in the naturally occurring mutants found in human neuroblastomas

1 reference

12 December 2020

The effects of combining ionizing radiation and adenoviral p53 therapy in nasopharyngeal carcinoma

1 reference

12 December 2020

Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin

1 reference

12 December 2020

A novel protein with strong homology to the tumor suppressor p53.

1 reference

12 December 2020

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 reference

12 December 2020

Absence of mutation of the p73 gene localized at chromosome 1p36.3 in hepatocellular carcinoma

1 reference

12 December 2020

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1 reference

12 December 2020

Rhabdomyosarcoma in children: epidemiologic study and identification of a familial cancer syndrome

1 reference

12 December 2020

A novel germ-line mutation in the noncoding region of the p53 gene in a Li-Fraumeni family

1 reference

12 December 2020

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome

1 reference

12 December 2020

DNA damage enables p73

1 reference

12 December 2020

Structural aspects of the p53 protein in relation to gene evolution

1 reference

12 December 2020

Regulation of Mdm2-directed degradation by the C terminus of p53.

1 reference

12 December 2020

Functions of the p53 Protein in Growth Regulation and Tumor Suppression

1 reference

12 December 2020

High frequency of germline p53 mutations in childhood adrenocortical cancer

1 reference

12 December 2020

Wild-type p53 induces apoptosis in a Burkitt lymphoma (BL) line that carries mutant p53.

1 reference

12 December 2020

Susceptibility to radiation-carcinogenesis and accumulation of chromosomal breakage in p53 deficient mice.

1 reference

12 December 2020

Training viruses to attack cancers

1 reference

12 December 2020

A cancer family syndrome in twenty-four kindreds

1 reference

12 December 2020

1 reference

12 December 2020

Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies

1 reference

12 December 2020

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

1 reference

12 December 2020

Identifiers

DOI

10.1023/A:1010636426860

1 reference

Dimensions Publication ID

1 August 2017

1008513051

0 references

1 reference