(Q34284204)

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Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associated μ opioid receptor (MOR-1) splice variants

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associated μ opioid receptor (MOR-1) splice variants (English)

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

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Susruta Majumdar

1

object named as

Susruta Majumdar

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Europe PubMed Central

PubMed publication ID

1 August 2017

author name string

Joan Subrath

2

1 reference

Europe PubMed Central

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1 August 2017

Valerie Le Rouzic

3

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Europe PubMed Central

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1 August 2017

Lisa Polikar

4

1 reference

Europe PubMed Central

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1 August 2017

Maxim Burgman

5

1 reference

Europe PubMed Central

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1 August 2017

Kuni Nagakura

6

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Europe PubMed Central

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1 August 2017

Julie Ocampo

7

1 reference

Europe PubMed Central

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1 August 2017

Nathan Haselton

8

1 reference

Europe PubMed Central

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1 August 2017

Anna R Pasternak

9

1 reference

Europe PubMed Central

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1 August 2017

Steven Grinnell

10

1 reference

Europe PubMed Central

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1 August 2017

Ying-Xian Pan

11

1 reference

Europe PubMed Central

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1 August 2017

Gavril W Pasternak

12

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1 August 2017

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publication date

16 July 2012

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Europe PubMed Central

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1 August 2017

Journal of Medicinal Chemistry

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Europe PubMed Central

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1 August 2017

55

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Europe PubMed Central

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1 August 2017

14

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

6352-6362

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

6 July 2018

Structure selectivity relationship studies of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan derivatives toward the development of the mu opioid receptor antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

6 July 2018

Utilization of halogen bond in lead optimization: a case study of rational design of potent phosphodiesterase type 5 (PDE5) inhibitors

1 reference

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6 July 2018

Generation of novel radiolabeled opiates through site-selective iodination

1 reference

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6 July 2018

N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

6 July 2018

Identification and characterization of seven new exon 11-associated splice variants of the rat μ opioid receptor gene, OPRM1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

6 July 2018

A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

6 July 2018

A medicinal chemist's guide to molecular interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

6 July 2018

Synthesis and pharmacological evaluation of 6-naltrexamine analogs for alcohol cessation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

6 July 2018

Design, synthesis, and biological evaluation of 6alpha- and 6beta-N-heterocyclic substituted naltrexamine derivatives as mu opioid receptor selective antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

6 July 2018

Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

6 July 2018

Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

6 July 2018

Identification and characterization of six new alternatively spliced variants of the human mu opioid receptor gene, Oprm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

6 July 2018

Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: dissociation of affinity and efficacy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

6 July 2018

Protein measurement with the Folin phenol reagent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

6 July 2018

3-iodo-4-phenoxypyridinones (IOPY's), a new family of highly potent non-nucleoside inhibitors of HIV-1 reverse transcriptase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

6 July 2018

Molecular identification and functional expression of mu 3, a novel alternatively spliced variant of the human mu opiate receptor gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

6 July 2018

Generation of the mu opioid receptor (MOR-1) protein by three new splice variants of the Oprm gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

6 July 2018

Expression of two variants of the human mu opioid receptor mRNA in SK-N-SH cells and human brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

6 July 2018

Classification of multiple morphine and enkephalin binding sites in the central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

6 July 2018

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

6 July 2018

Estimation of the affinity of naloxone at supraspinal and spinal opioid receptors in vivo: studies with receptor selective agonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

6 July 2018

Separation of opioid analgesia from respiratory depression: evidence for different receptor mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

6 July 2018

Pharmacological actions of a novel mixed opiate agonist/antagonist: naloxone benzoylhydrazone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

6 July 2018

Synthesis and biological evaluation of alpha- and beta-6-amido derivatives of 17-cyclopropylmethyl-3, 14beta-dihydroxy-4, 5alpha-epoxymorphinan: potential alcohol-cessation agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

28 October 2018

Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: a new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

28 October 2018

Identification of four novel exon 5 splice variants of the mouse mu-opioid receptor gene: functional consequences of C-terminal splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

28 October 2018

Synthesis and biological evaluation of some 6-arylamidomorphines as analogues of morphine-6-glucuronide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

28 October 2018

Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

28 October 2018

Isolation and expression of a novel alternatively spliced mu opioid receptor isoform, MOR-1F.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

28 October 2018

Identification and characterization of three new alternatively spliced mu-opioid receptor isoforms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412067

28 October 2018

Stereochemical studies on medicinal agents. 23. Synthesis and biological evaluation of 6-amino derivatives of naloxone and naltrexone

1 reference

https://pubmed.ncbi.nlm.nih.gov/22734622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissociation of morphine's analgesic and respiratory depressant actions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22734622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Separation of morphine analgesia from physical dependence.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22734622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential blockade by naloxonazine of two mu opiate actions: analgesia and inhibition of gastrointestinal transit

1 reference

https://pubmed.ncbi.nlm.nih.gov/22734622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-activity relationship for the binding of nucleoside ligands to adenosine kinase from Toxoplasma gondii

1 reference

https://pubmed.ncbi.nlm.nih.gov/22734622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM300305C

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

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