(Q34291931)

1 August 2017

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title

Thrombin domains: structure, function and interaction with platelet receptors (English)

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1 August 2017

author name string

Raimondo De Cristofaro

series ordinal

1

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1 August 2017

Erica De Candia

series ordinal

2

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1 August 2017

language of work or name

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1 June 2003

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Journal of Thrombosis and Thrombolysis

1 August 2017

published in

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1 August 2017

volume

15

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1 August 2017

issue

3

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1 August 2017

page(s)

151-163

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An Arg-Gly-Asp sequence within thrombin promotes endothelial cell adhesion

1 August 2017

cites work

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12 December 2020

The structure of a complex of recombinant hirudin and human alpha-thrombin

1 reference

12 December 2020

Thrombin-mediated proteolysis of factor V resulting in gradual B-domain release and exposure of the factor Xa-binding site

1 reference

12 December 2020

The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

1 reference

12 December 2020

Reconstitution of catalytically competent human .zeta.-thrombin by combination of .zeta.-thrombin residues A1-36 and B1-148 and an Escherichia coli expressed polypeptide corresponding to .zeta.-thrombin residues B149-259

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12 December 2020

Enzymatic properties of proteolytic derivatives of human alpha-thrombin

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12 December 2020

Structural and functional diversity in the leucine-rich repeat family of proteins

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12 December 2020

An extensive interaction interface between thrombin and factor V is required for factor V activation

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12 December 2020

Interaction of the factor XIII activation peptide with alpha -thrombin. Crystal structure of its enzyme-substrate analog complex

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12 December 2020

Allosteric modulation of the activity of thrombin

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12 December 2020

Characterization of the residues involved in the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor

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12 December 2020

Reconstitution of the human endothelial cell protein C receptor with thrombomodulin in phosphatidylcholine vesicles enhances protein C activation

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12 December 2020

The molecular basis of thrombin allostery revealed by a 1.8 A structure of the "slow" form

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12 December 2020

Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha

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12 December 2020

Identification of thrombin residues that modulate its interactions with antithrombin III and alpha 1-antitrypsin

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12 December 2020

Glu-192----Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin

1 reference

12 December 2020

Evidence for common structural changes in thrombin induced by active-site or exosite binding

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12 December 2020

Binding of human alpha-thrombin to platelet GpIb: energetics and functional effects.

1 reference

12 December 2020

Mutagenesis of thrombin selectively modulates inhibition by serpins heparin cofactor II and antithrombin III. Interaction with the anion-binding exosite determines heparin cofactor II specificity

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12 December 2020

The role of the insertion loop around tryptophan 148 in tthe activity of thrombin

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12 December 2020

The oligosaccharide of human thrombin: investigations of functional significance

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12 December 2020

Direct thrombin inhibitors in acute coronary syndromes: present and future

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12 December 2020

Characterization of thrombin-induced leukocyte rolling and adherence: a potential proinflammatory role for proteinase-activated receptor-4

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12 December 2020

Mapping of the thrombin des-ETW conformation by using site-directed mutants of hirudin. Evidence for the induction of nonlocal modifications by mutagenesis

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12 December 2020

Thrombin is a Na(+)-activated enzyme

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12 December 2020

The clot thickens: clues provided by thrombin structure.

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12 December 2020

Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombin

1 reference

12 December 2020

Heparin cofactor II is regulated allosterically and not primarily by template effects. Studies with mutant thrombins and glycosaminoglycans.

1 reference

12 December 2020

Human neutrophil elastase alters human alpha-thrombin function: limited proteolysis near the gamma-cleavage site results in decreased fibrinogen clotting and platelet-stimulatory activity

1 reference

12 December 2020

Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin

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12 December 2020

Allosteric modulation of BPTI interaction with human alpha- and zeta-thrombin

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12 December 2020

Thrombin interacts with thrombomodulin, protein C, and thrombin-activatable fibrinolysis inhibitor via specific and distinct domains

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12 December 2020

Thrombin interaction with platelet GpIb: structural mapping and effects on platelet activation (review).

1 reference

12 December 2020

Protease-activated G protein-coupled receptors on human platelets and endothelial cells

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12 December 2020

Thrombin-mediated feedback activation of factor XI on the activated platelet surface is preferred over contact activation by factor XIIa or factor XIa.

1 reference

12 December 2020

The COOH-terminal domain of hirudin. An exosite-directed competitive inhibitor of the action of alpha-thrombin on fibrinogen.

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12 December 2020

Human protein C receptor is present primarily on endothelium of large blood vessels: implications for the control of the protein C pathway

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12 December 2020

Structure of a nonadecapeptide of the fifth EGF domain of thrombomodulin complexed with thrombin

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12 December 2020

High-affinity alpha-thrombin binding to platelet glycoprotein Ib alpha: identification of two binding domains

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12 December 2020

Molecular mapping of the heparin-binding exosite of thrombin

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12 December 2020

Amelioration of collagen-induced arthritis by thrombin inhibition

1 reference

12 December 2020

Molecular recognition by thrombin. Role of the slow-->fast transition, site-specific ion binding energetics and thermodynamic mapping of structural components

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12 December 2020

Proteolytic derivatives of thrombin

1 reference

12 December 2020

The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin

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12 December 2020

The linkage between binding of the C-terminal domain of hirudin and amidase activity in human alpha-thrombin

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12 December 2020

Comparative analysis of haemostatic proteinases: structural aspects of thrombin, factor Xa, factor IXa and protein C

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12 December 2020

Effects of protons on the thrombin-fibrinogen interaction

1 reference

12 December 2020

Crystal structure of the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor

1 reference

12 December 2020

Linkage between proton binding and amidase activity in human alpha-thrombin: effect of ions and temperature

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12 December 2020

Role of thrombin signalling in platelets in haemostasis and thrombosis

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12 December 2020

Tryptophan 60-D in the B-insertion loop of thrombin modulates the thrombin-antithrombin reaction

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12 December 2020

Thrombomodulin increases the rate of thrombin inhibition by BPTI

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12 December 2020

Electrostatic steering and ionic tethering in the formation of thrombin-hirudin complexes: the role of the thrombin anion-binding exosite-I

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12 December 2020

The thrombin receptor in the nervous system.

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12 December 2020

Crystal structure of thrombin-ecotin reveals conformational changes and extended interactions

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12 December 2020

Crystal structure of the platelet glycoprotein Ib(alpha) N-terminal domain reveals an unmasking mechanism for receptor activation

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12 December 2020

Factor XIII: structure, activation, and interactions with fibrinogen and fibrin.

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12 December 2020

The glycoprotein Ib-IX-V complex in platelet adhesion and signaling

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12 December 2020

Identification of basic amino acid residues in thrombin essential for heparin-catalyzed inactivation by antithrombin III

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12 December 2020

Interaction of the 268-282 region of glycoprotein Ibalpha with the heparin-binding site of thrombin inhibits the enzyme activation of factor VIII.

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12 December 2020

Role of proexosite I in factor Va-dependent substrate interactions of prothrombin activation

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12 December 2020

PAR3 is a cofactor for PAR4 activation by thrombin

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12 December 2020

Human alpha- to zeta-thrombin cleavage occurs with neutrophil cathepsin G or chymotrypsin while fibrinogen clotting activity is retained

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12 December 2020

Conformational transitions linked to active site ligation in human thrombin: effect on the interaction with fibrinogen and the cleavable platelet receptor

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12 December 2020

Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation

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12 December 2020

Role of thrombin anion-binding exosite-I in the formation of thrombin-serpin complexes

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12 December 2020

Differentiation of the two forms of GPIb functioning as receptors for alpha-thrombin and von Willebrand factor: Ca2+ responses of protease-treated human platelets activated with alpha-thrombin and the tethered ligand peptide

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12 December 2020

Contributions of glycoprotein Ib and the seven transmembrane domain receptor to increases in platelet cytoplasmic [Ca2+] induced by alpha-thrombin

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12 December 2020

Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain

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12 December 2020

Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93, 97, and 101

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12 December 2020

Glu192-->Gln substitution in thrombin yields an enzyme that is effectively inhibited by bovine pancreatic trypsin inhibitor and tissue factor pathway inhibitor.

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12 December 2020

Evidence that human alpha-thrombin is a monovalent cation-activated enzyme

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12 December 2020

Late-fibrin(ogen) fragment E modulates human alpha-thrombin specificity

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12 December 2020

The Na+ binding site of thrombin

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12 December 2020

The GPIb thrombin-binding site is essential for thrombin-induced platelet procoagulant activity

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12 December 2020

The interaction of thrombin with fibrinogen. A structural basis for its specificity

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12 December 2020

Characterization of the kinetic pathway for fibrin promotion of alpha-thrombin-catalyzed activation of plasma factor XIII

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12 December 2020

Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin

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12 December 2020

Solution structure of the smallest cofactor-active fragment of thrombomodulin

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12 December 2020

Effect of high- and low-molecular-weight heparins on thrombin-thrombomodulin interaction and protein C activation

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12 December 2020

The dual role of thrombin's anion-binding exosite-I in the recognition and cleavage of the protease-activated receptor 1

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12 December 2020

The role of thrombin's Tyr-Pro-Pro-Trp motif in the interaction with fibrinogen, thrombomodulin, protein C, antithrombin III, and the Kunitz inhibitors

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12 December 2020

Characterization of proexosite I on prothrombin

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12 December 2020

Structural and functional mapping of the thrombin domain involved in the binding to the platelet glycoprotein Ib.

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12 December 2020

Oligonucleotide inhibitors of human thrombin that bind distinct epitopes

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12 December 2020

Interaction of thrombin des-ETW with antithrombin III, the Kunitz inhibitors, thrombomodulin and protein C. Structural link between the autolysis loop and the Tyr-Pro-Pro-Trp insertion of thrombin

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12 December 2020

Crystallographic structure of human gamma-thrombin

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12 December 2020

Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex

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12 December 2020

Allosteric effects potentiating the release of the second fibrinopeptide A from fibrinogen by thrombin

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12 December 2020

Elements of the primary structure of thrombomodulin required for efficient thrombin-activable fibrinolysis inhibitor activation

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12 December 2020

Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets

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12 December 2020

Mechanistic studies on thrombin catalysis

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12 December 2020

Platelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin.

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12 December 2020

Molecular defects of platelets in Bernard-Soulier syndrome

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12 December 2020

Allosteric changes in thrombin's activity produced by peptides corresponding to segments of natural inhibitors and substrates

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12 December 2020

Monocyte chemotaxis: stimulation by specific exosite region in thrombin

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12 December 2020

Three-dimensional modeling of thrombin-fibrinogen interaction

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12 December 2020

Molecular mechanisms of thrombin function

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12 December 2020

Thrombin interaction with platelet GpIB: role of the heparin binding domain

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12 December 2020

Regulation of blood coagulation

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12 December 2020

Linkage between proton binding and amidase activity in human gamma-thrombin

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12 December 2020

Unexpected crucial role of residue 225 in serine proteases

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12 December 2020

Involvement of thrombin anion-binding exosites 1 and 2 in the activation of factor V and factor VIII

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12 December 2020

Effect of protons on the amidase activity of human alpha-thrombin. Analysis in terms of a general linkage scheme.

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12 December 2020

Predominant contribution of surface approximation to the mechanism of heparin acceleration of the antithrombin-thrombin reaction. Elucidation from salt concentration effects.

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12 December 2020

Binding of the bovine basic pancreatic trypsin inhibitor (Kunitz) to human alpha-, beta- and gamma-thrombin; a kinetic and thermodynamic study

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12 December 2020

Identification of critical residues on thrombin mediating its interaction with fibrin

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12 December 2020

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

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12 December 2020

Electrostatic interactions in the association of proteins: an analysis of the thrombin-hirudin complex

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12 December 2020

Refined structure of the hirudin-thrombin complex

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12 December 2020

Effect of sodium on the energetics of thrombin-thrombomodulin interaction and its relevance for protein C hydrolysis

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12 December 2020

Theory of allosteric effects in serine proteases.

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12 December 2020

Comparative analysis of structurally defined heparin binding sequences reveals a distinct spatial distribution of basic residues.

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12 December 2020

Helix D elongation and allosteric activation of antithrombin.

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12 December 2020

The Asp(272)-Glu(282) region of platelet glycoprotein Ibalpha interacts with the heparin-binding site of alpha-thrombin and protects the enzyme from the heparin-catalyzed inhibition by antithrombin III

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12 December 2020

Molecular and functional characterization of a natural homozygous Arg67His mutation in the prothrombin gene of a patient with a severe procoagulant defect contrasting with a mild hemorrhagic phenotype

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12 December 2020

The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity

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12 December 2020

Thrombin-induced platelet activation is inhibited by high- and low-molecular-weight heparin

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12 December 2020

Thrombin modulates and reverses neuroblastoma neurite outgrowth

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12 December 2020

Identification of residues linked to the slow-->fast transition of thrombin

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12 December 2020

Hemostatic risk factors for atherothrombotic disease: an epidemiologic view

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12 December 2020

Substrate-assisted catalysis of the PAR1 thrombin receptor. Enhancement of macromolecular association and cleavage

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12 December 2020

Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes

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12 December 2020

Molecular mapping of thrombin-receptor interactions

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12 December 2020

10.1023/B:THRO.0000011370.80989.7B

Identifiers

DOI

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Dimensions Publication ID

1 August 2017

1047279730

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