(Q34293956)

1 August 2017

Is caspase-3 inhibition a valid therapeutic strategy in cerebral ischemia? (English)

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1 August 2017

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H Loetscher

1

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1 August 2017

O Niederhauser

series ordinal

2

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1 August 2017

J Kemp

series ordinal

3

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1 August 2017

R Gill

series ordinal

4

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1 August 2017

1 July 2001

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1 August 2017

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1 August 2017

6

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1 August 2017

671-680

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1 August 2017

13

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A matter of life and cell death

1 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Cell Death in Development

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

The changing landscape of ischaemic brain injury mechanisms.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

The central executioners of apoptosis: caspases or mitochondria?

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Caspases: a decade of death research

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Caspase structure, proteolytic substrates, and function during apoptotic cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Caspases: enemies within

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Mammalian cell death proteases: a family of highly conserved aspartate specific cysteine proteases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Serial killers: ordering caspase activation events in apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Biochemical pathways of caspase activation during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Requirement of caspase-3(-like) protease-mediated hydrogen peroxide production for apoptosis induced by various anticancer drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Mitochondria and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Caspase activation without death

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

A caspase-3-like protease is involved in NF-kappaB activation induced by stimulation of N-methyl-D-aspartate receptors in rat striatum

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Blockade of the NMDA receptor increases developmental apoptotic elimination of granule neurons and activates caspases in the rat cerebellum.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

NMDA receptor-mediated K+ efflux and neuronal apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Calpain and caspase: can you tell the difference?

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Evidence for hypoxia-induced, programmed cell death of cultured neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

A pathway of neuronal apoptosis induced by hypoxia/reoxygenation: roles of nuclear factor-kappaB and Bcl-2

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Caspase inhibitors are functionally neuroprotective against oxygen glucose deprivation induced CA1 death in rat organotypic hippocampal slices

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Differential requirement for caspase 9 in apoptotic pathways in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Identification of a new caspase homologue: caspase-14

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Caspase-14 is a novel developmentally regulated protease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Molecular cloning and identification of murine caspase-8.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Cloning and expression of a rat brain interleukin-1beta-converting enzyme (ICE)-related protease (IRP) and its possible role in apoptosis of cultured cerebellar granule neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Postnatal distribution of cpp32/caspase 3 mRNA in the mouse central nervous system: an in situ hybridization study.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Changes in caspase expression in Alzheimer's disease: comparison with development and aging.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia: a mechanism of "pathological apoptosis"?

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Involvement of caspase-3 in cell death after hypoxia-ischemia declines during brain maturation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Presenilins are processed by caspase-type proteases.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Ultrastructural morphological changes are not characteristic of apoptotic cell death following focal cerebral ischaemia in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

The shape of cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Mitochondrial membrane potential and neuronal glutamate excitotoxicity: mortality and millivolts

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Neuronal death in brain infarcts in man

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Potential mechanisms of interleukin-1 involvement in cerebral ischaemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

DNA fragmentation follows delayed neuronal death in CA1 neurons exposed to transient global ischemia in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Apoptotic features of selective neuronal death in ischemia, epilepsy and gp 120 toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Gene expression induced by cerebral ischemia: an apoptotic perspective

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Methods for detecting and quantifying apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Granzyme B/Perforin-Mediated Apoptosis of Jurkat Cells Results in Cleavage of Poly(ADP-ribose) Polymerase to the 89-kDa Apoptotic Fragment and Less Abundant 64-kDa Fragment

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Distinct cleavage products of nuclear proteins in apoptosis and necrosis revealed by autoantibody probes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Apoptosis in the absence of poly-(ADP-ribose) polymerase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Early and sequential recruitment of apoptotic effectors after focal permanent ischemia in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Cytosolic redistribution of cytochrome c after transient focal cerebral ischemia in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Mitochondrial release of cytochrome c corresponds to the selective vulnerability of hippocampal CA1 neurons in rats after transient global cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Activation of CPP-32 protease in hippocampal neurons following ischemia and epilepsy.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Differential changes of bax, caspase-3 and p21 mRNA expression after transient focal brain ischemia in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Caspases as treatment targets in stroke and neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Parallel gene expression monitoring using oligonucleotide probe arrays of multiple transcripts with an animal model of focal ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Histochemical cytochrome c oxidase activity and caspase-3 in gerbil hippocampal CA1 neurons after transient forebrain ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

cpp32 messenger RNA neosynthesis is induced by fatal axotomy and is not regulated by athanatal Bcl-2 over-expression

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Correlation Between Caspase-3 Activation and Three Different Markers of DNA Damage in Neonatal Cerebral Hypoxia-Ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Caspase-3 activation after neonatal rat cerebral hypoxia-ischemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Apoptosis has a prolonged role in the neurodegeneration after hypoxic ischemia in the newborn rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Caspase inhibitors reduce neuronal injury after focal but not global cerebral ischemia in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Inhibition of caspases prevents cell death of hippocampal CA1 neurons, but not impairment of hippocampal long-term potentiation following global ischemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Expression of Caspases and Their Substrates in the Rat Model of Focal Cerebral Ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

A caspase inhibitor blocks ischaemia-induced delayed neuronal death in the gerbil.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Cortical protection by localized striatal injection of IL-1ra following cerebral ischemia in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Caspase-8 specificity probed at subsite S(4): crystal structure of the caspase-8-Z-DEVD-cho complex

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Transient global forebrain ischemia induces a prolonged expression of the caspase-3 mRNA in rat hippocampal CA1 pyramidal neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Attenuation of ischemia-induced cellular and behavioral deficits by X chromosome-linked inhibitor of apoptosis protein overexpression in the rat hippocampus.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Topical application of neurotrophin-3 attenuates ischemic brain injury after transient middle cerebral artery occlusion in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2901826-8

7 January 2021

10.1016/S1359-6446(01)01826-8

Identifiers

DOI

1 reference

1 August 2017

1 reference