(Q34302130)

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Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16414988%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1 (English)

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15 January 2020

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15 January 2020

Bernard Roizman

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Bernard Roizman

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15 January 2020

Ralph Weichselbaum

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Ralph R Weichselbaum

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15 January 2020

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Kerrington D Smith

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15 January 2020

James J Mezhir

2

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15 January 2020

Kai Bickenbach

3

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15 January 2020

Jula Veerapong

4

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15 January 2020

Mitchell C Posner

6

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15 January 2020

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1 February 2006

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15 January 2020

Journal of Virology

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15 January 2020

80

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15 January 2020

3

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15 January 2020

1110-1120

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15 January 2020

Targeting the mitogen-activated protein kinase cascade to treat cancer

1 reference

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Targets and mechanisms for the regulation of translation in malignant transformation

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Herpes simplex virus 1 gene products occlude the interferon signaling pathway at multiple sites

1 reference

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Defects in translational regulation mediated by the alpha subunit of eukaryotic initiation factor 2 inhibit antiviral activity and facilitate the malignant transformation of human fibroblasts

1 reference

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Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling

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6 July 2018

Regulation of herpes simplex virus gamma(1)34.5 expression and oncolysis of diffuse liver metastases by Myb34.5.

1 reference

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6 July 2018

Signal integration via PKR.

1 reference

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6 July 2018

Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals

1 reference

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6 July 2018

Oncogenes in Ras signalling pathway dictate host-cell permissiveness to herpes simplex virus 1.

1 reference

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6 July 2018

Paired human fibrosarcoma cell lines that possess or lack endogenous mutant N-ras alleles as experimental model for Ras signaling pathways

1 reference

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6 July 2018

Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals

1 reference

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Dissection of Ras-dependent signaling pathways controlling aggressive tumor growth of human fibrosarcoma cells: evidence for a potential novel pathway

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6 July 2018

Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial

1 reference

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6 July 2018

Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma

1 reference

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Specific phenotypic restoration of an attenuated virus by knockout of a host resistance gene

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6 July 2018

The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal

1 reference

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6 July 2018

Rsk1 mediates a MEK-MAP kinase cell survival signal

1 reference

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6 July 2018

Creation of human tumour cells with defined genetic elements

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Lack of elevated MAP kinase (Erk) activity in pancreatic carcinomas despite oncogenic K-ras expression.

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6 July 2018

Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

1 reference

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6 July 2018

The herpes simplex virus US11 protein effectively compensates for the gamma1(34.5) gene if present before activation of protein kinase R by precluding its phosphorylation and that of the alpha subunit of eukaryotic translation initiation factor 2.

1 reference

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6 July 2018

Molecular mechanisms of interferon resistance mediated by viral-directed inhibition of PKR, the interferon-induced protein kinase

1 reference

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6 July 2018

The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-

1 reference

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Interdependent domains controlling the enzymatic activity of mitogen-activated protein kinase kinase 1.

1 reference

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6 July 2018

Loss of oncogenic ras expression does not correlate with loss of tumorigenicity in human cells

1 reference

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Herpes simplex virus 1 gamma(1)34.5 gene function, which blocks the host response to infection, maps in the homologous domain of the genes expressed during growth arrest and DNA damage

1 reference

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Constitutive activation of Mek1 by mutation of serine phosphorylation sites

1 reference

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1 reference

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Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase

1 reference

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Molecular mechanisms responsible for malignant transformation by regulatory and catalytic domain variants of the interferon-induced enzyme RNA-dependent protein kinase

1 reference

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12 December 2020

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10.1128/JVI.80.3.1110-1120.2006

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Europe PubMed Central

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15 January 2020

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Europe PubMed Central

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15 January 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16414988%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

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